t f p g+ YouTube icon

On Reading the Cell’s Signature

Bookmark and Share

January 7, 2010 Tags: Design
On Reading the Cell’s Signature

Today's entry was written by Francisco Ayala. Please note the views expressed here are those of the author, not necessarily of BioLogos. You can read more about what we believe here.

Note: Dr. Francisco Ayala is widely regarded as one of the world’s leading evolutionary biologists. He came to the United States to study under the legendary Theodosius Dobzhansky, only to go on from there to become legendary himself.

Dr. Ayala has been a moderating influence in the science/religion dialog. We have seen him kindly but forcefully admonish new atheists for their style (this conference is a good example). He also is noted for his admonition of those associated with the Intelligent Design movement. He, like us, believes the approach taken by those in the Movement creates very significant theological and scientific problems. We sent him a copy of Stephen C. Meyer’s Signature in the Cell. The essay below is his response. We especially ask you to take note of this sentence: “I do think that people of faith may find in the world many reasons that support their belief in God. But I don’t think that intelligent design is one of them.”

Note added on March 8, 2010: Dr. Ayala was not asked to do a formal review of "Signature in the Cell." He was asked to enter into the conversation initiated by our essay posted on December 28, and, at his request, was sent a copy of the book. This was his response.

How should a person of faith respond to Signature of the Cell? I am an evolutionary scientist who would suggest the following considerations.

The keystone argument of Signature of the Cell is that chance, by itself, cannot account for the genetic information found in the genomes of organisms. I agree. And so does every evolutionary scientist, I presume. Why, then, spend chapter after chapter and hundreds of pages of elegant prose to argue the point? It is as if in a book about New York, the author would tell us that New York is not in Europe, and then dedicate most of the book to advancing evidence that, indeed, truly, New York is not in Europe.

Signature of the Cell offers Intelligent Design (ID) as the alternative explanation to chance in order to account for genetic information. This suggestion turns out to be no more convincing than a proposal by the author of the book about New York, who having exhausted all possible ways of telling us that New York is not in Europe, would now offer Peoria as the alternative city to visit. We would rather read about New York’s architecture, splendid avenues, and great parks; about the rich culture and ethnic diversity of the city; about its restaurants, concert venues, theatres, and wonderful sights in and around the city. But regarding natural selection, genetics, ecology, development, physiology, and behavior in the evolution of genetic information, there is nothing substantive in Signature of the Cell.

Christians and other people of faith should be troubled about Signature of the Cell for several reasons. One is that Meyer avoids consideration of the negative implications of ID as an explanation of the origin of genetic information, which is his main subject. According to Meyer, ID provides a more satisfactory explanation of the human genome than evolution does. ID’s explanations envision “discrete or discontinuous intelligent activity in the history of life” (p. 481). Scientists have now obtained the complete DNA sequence of the human genome. The genome has a length of about three billion nucleotides, the “letters” of the DNA alphabet. Scientists have also obtained the complete DNA sequence of the chimpanzee genome—also three billion letters long—and of several hundred other species of organisms. How can we envision the “discrete or discontinuous activity” of the Intelligent Designer? The human and chimpanzee genomes differ from each other in just a few percent of the DNA letters, less than two percent in the genes that code for proteins. Did the Designer tweak the chimpanzee genome to make the human genome? Or, perhaps more likely, did the Designer use a preexisting genome and tweak it a bit to make the human genome and tweak it a different way to make the chimpanzee genome? Did the Designer go on tweaking genomes a bit at a time to design the genome of the gorilla and other primates, and more and more tweaking for other animals, all the way down to mice, and even to fruitflies, with which we share a good fraction of the genome?

The human genome includes about twenty-five thousand genes and lots of other (mostly short) switch sequences, which turn on and off genes in different tissues and at different times and play other functional roles. There are also lots and lots of DNA sequences that are nonsensical. For example, there are about one million virtually identical Alu sequences that are each three-hundred letters (nucleotides) long and are spread throughout the human genome. Think about it: there are in the human genome about twenty-five thousand genes, but one million interspersed Alu sequences; forty times more Alu sequences than genes. It is as if the editor of Signature of the Cell would have inserted between every two pages of Meyer’s book, forty additional pages, each containing the same three hundred letters. Likely, Meyer would not think of his editor as being “intelligent.” Would a function ever be found for these one million nearly identical Alu sequences? It seems most unlikely. In fact, we know how these sequences come about: one new Alu sequence appears in the genome for every ten newborns, generation after generation. The Designer at work? Unlikely: many of these sequences damage the genome causing abortion of the fetus during the early weeks of life.

Perhaps one could attribute the obnoxious presence of the Alu sequences to degenerative biological processes that are not the result of ID. But was the Designer incompetent or malevolent in not avoiding the eventuality of this degeneration? Come to think of it: why is it that most species become extinct? More than two million species of organisms now live on Earth. But the fossil record shows that more than ninety-nine percent of all species that ever lived became extinct. That is more than one billion extinct species. How come? Is this dreadful waste an outcome intended by the Designer? Or is extinction an outcome of degeneration of genetic information and biological processes? If so, was the Designer not intelligent enough or benevolent enough to avoid the enormity of this waste?

Meyer asserts that the theory of intelligent design has religious implications. “Those who believe in a transcendent God may, therefore, find support for their belief from the biological evidence that supports the theory of intelligent design” (p. 444). I do think that people of faith may find in the world many reasons that support their belief in God. But I don’t think that intelligent design is one of them. Quite the contrary. Indeed, there are good reasons to reject ID on religious grounds, in addition to scientific grounds. The biological information encased in the genome determines the traits that the developing organism will have, in humans as well as in other organisms. But humans are chock-full of design defects. We have a jaw that is not sufficiently large to accommodate all of our teeth, so that wisdom teeth have to be removed and other teeth straightened by an orthodontist. Our backbone is less than well designed for our bipedal gait, resulting in back pain and other problems in late life. The birth canal is too narrow for the head of the newborn to pass easily through it, so that millions of innocent babies—and their mothers—have died in childbirth throughout human history.

I could go on about human features that betray a design that certainly is not intelligent. I will add only one more consideration. More that twenty percent of all human pregnancies end in spontaneous abortion during the first two months of pregnancy. That is because the human genome, the human reproductive system, is so poorly designed. Do I want to attribute this egregiously defective design to God, to the omnipotent and benevolent God of the Christian faith? No, I don’t. It would not do to say that God designed intelligently the human genome and that it then decayed owing to natural processes. If God would have designed the human genome, surely He would have done it so that this enormous misfortune would not happen. Think of it: twenty percent of all human pregnancies amount to twenty million abortions every year. I shudder at the thought of this calamity being attributed to God’s specific design of the human genome. To me, this attribution would amount to blasphemy.

Before the scientific revolution of the sixteenth and seventeenth centuries, earthquakes, volcanic eruptions, and the like were attributed to direct action by God, so that the tsunami that five years ago killed two hundred fifty thousand Sumatrans might have been interpreted as God’s punishment. Now we know that these catastrophes are the result of natural processes. Similarly, people of faith would do better to attribute the mishaps caused by defective genomes to the vagaries of natural selection and other processes of biological evolution, rather than to God’s design.

Francisco Ayala is a philosopher and the Donald Bren Professor of Biological Sciences at the University of California, Irvine, and a former Dominican priest. He is a popular author and lecturer on the compatibility of science and religion. He has received numerous awards and honors, including a 2001 National Medal of Science, the highest honor given by the government to scientists, and the 2010 Templeton Prize.

Learn More

View the archived discussion of this post

This article is now closed for new comments. The archived comments are shown below.

Page 8 of 8   « 5 6 7 8
meestahjoose - #7231

March 20th 2010

Re: post 2200

So that’s what science is good for?  Speed and comfort?  How about basic knowledge and understanding, for its own sake?  It may or may not contribute to an improvement in the physical quality of life.


Stephen Bishop - #13858

May 15th 2010

Why would a logical, philosopher, depend on the logical fallacy of arguing from conclusion?  More specifically, Ayala asserts that a designer (i.e. God) would never have produced what exists, or allowed it to become so.

Why would a man who lacks the sound capacity for logical reasoning, as Ayala has demonstrated here, presume to know the mind of God sufficiently to assert what we would/would not have done?

And why would a faith-based rationale be used to undercut a scientific argument on the basis of separating science and religion?

But if faith-based reasons are to be included, then Ayala should at least reflect the best faith-based answers to his objections.  On the other hand, he only lasted a year as a Priest.

Christina Wilson - #21272

July 10th 2010

Please read Dr. Stephen Meyer’s response to Dr. Ayala in the digital book, Signature of
Controversy, edited by David Klinghoffer. The book is available through the Discovery Institute Press website. In my opinion, Dr. Meyer completely wipes out Dr. Ayala’s argument.

Josh - #34080

October 9th 2010

I just finished reading Meyer’s book (including the appendixes and many of the footnotes). Ayala’s review seems odd to me because it doesn’t discuss the merits of any of Meyer’s arguments. Also, I’m not sure I understand what Ayala means when he says that Meyer’s keystone argument was that “chance, by itself, cannot account for the genetic information found in the genomes of organisms.” The book I read had several core chapters dealing with non-chance (non-design) mechanisms. Anyway, Meyer’s review didn’t interact with the book I read.

Ayala says something that deserves clarification. He says, “ID’s explanations envision “discrete or discontinuous intelligent activity in the history of life” (p. 481)” But on p. 481 Meyer is discussing different kinds of auxiliary design hypotheses, such as design with common descent or design with “discrete or discontinuous intelligent activity”. He’s not at all saying that it’s part of ID to decide between those auxiliary hypotheses. He’s not saying that it’s part of ID to envision discrete or discontinuous intelligent activity.

Feorhund - #60780

May 4th 2011

Dr. Meyer responded to this article. http://www.signatureinthecell.com/responses/

glsi - #64039

August 14th 2011

Dr. Ayala,

You seem kind of peeved about all those pages Dr. Meyer spent on the mathematically remote possibility of life springing up out of random chemical reactions.  I think he hit on a sore spot!  I have no idea why you’re talking about New York and Europe.

In fact, I just finished reading a book by WSU  science faculty members Lurquin and Stone entitled, Evolution and Religious Creation Myths.  The book is an attempt to convince its readers of the validity of Darwinian evolution.  A major theme of the book is, in fact, that life arose on Earth via random chemical reactions.  This is the central point of their summary remarks, and it’s probably fair to say they speak for a whole lot of evolutionists.

Are you simply nervous because you can’t name any of the purported chemical reactions which you evidently believe somehow knit together a living cell?  Because it seems like your scientific authority is very tenuous  when you can’t answer this question with any kind of empirical evidence and instead resort to your own theology and judgements on the construction of the DNA molecule.

Page 8 of 8   « 5 6 7 8