So, I’ve decided to try a slightly different approach for the next while—one that has these sorts of folks in mind. From time to time, you can still expect those more in-depth, technical articles, or perhaps a discussion of some new research that makes the popular press, or even an analysis of some new argument from the IDM or RTB. These will be breaks from the new routine, however. For the most part, we’re going to stick to the basics, much like you would if you took an introductory evolution course at a university. Don’t worry, though: this course doesn’t have any prerequisites! All that’s needed is a willingness to learn.

What you can expect

The goal of this course is straightforward: to provide evangelical Christians with a step-by-step introduction to the science of evolutionary biology.  This will provide benefits beyond just the joy of learning more about God’s wonderful creation. An understanding of the basic science of evolution is of great benefit for reflecting on its theological implications, since this reflection can then be done from a scientifically-informed perspective. From time to time we might comment briefly on some issues of theological interest (and suggest resources for those looking to explore those issues further), but for the most part, we’re going to focus on the science. For folks interested in the interaction between science and Christianity, I heartily recommend Ted Davis’ recent series as a fabulous introduction to the topic.

You can also expect a slow, patient pace. Since this course is intended for folks with little or no background in biology, we’re going to take our time to make sure no one gets left behind. This might be frustrating to folks who already know a fair bit about evolution. Hopefully even more knowledgeable readers will learn some new and interesting details along the way—but the goal will primarily be to help folks who are less well versed in evolution increase their understanding.

You can also expect a survey of many different areas that have some bearing on evolution. We’ll examine geology, paleontology, biogeography, genetics, and a host of other topics in order to provide a “big picture” overview. This broad-brush approach means that any given individual post will not necessarily be “convincing” to folks who have doubts about evolution. Think about assembling a large jigsaw puzzle: placing any individual piece, on its own, doesn’t convincingly demonstrate what the overall picture will show. This course will be like that. Each topic we cover will put a few pieces in place here and there, slowly building towards the final overall picture.

Since evolution is an active science, this process will also highlight where there are “missing pieces” that are still being sought by scientists. All of this is well and good, since the purpose of this course is not so much to convince anyone of the validity of evolutionary theory, but rather to inform readers about the nature and scope of evolution as a scientific theory in the present day. My goal is to provide readers with a basic understanding of what evolution is and how it works. Given that as the primary goal, if one finds the scope of the evidence ultimately convincing (or not) is somewhat beside the point. The intent here is to provide readers with information they can use to make their own, informed decision.

How you can help

First and foremost, you can help by spreading the word about this series to folks you think would be interested in learning more about evolution in a non-threatening environment. Secondly, you can help me by asking questions in the comments. One of the challenges of being a specialist is having the ability to put oneself in the shoes of someone just starting out. What might seem obvious to me may not seem obvious to you, and I hope you’ll feel that no question is too basic or too simplistic. If you’re wondering about something, it’s almost guaranteed that other folks are, too! So, please don’t be shy. I’ll do my best to answer questions in the comments, though I hope that some of our more skilled commenters will (respectfully!) help out here, as well. Finally, you can help by letting me know what broader areas of evolution you find confusing. I have my own ideas about what areas of evolution are commonly misunderstood, but I’d love to hear from readers about what areas they find difficult to understand. I’ll use this input to shape the topics I will cover as we go forward.

Getting started

In the next post in this course, we’ll dive into the course content by introducing two key areas: how scientific theories work in general, and how evolution in particular works as the current organizing theory of modern biology. 

More Than One Christian View

Many parents and pastors are wondering what to tell their children about creation and evolution. While Sunday school classes often cover Genesis 1 around kindergarten (with kids coloring pictures of what God created on each day), most curricula do not address science again before kids leave for college. Yet issues of creation and evolution can be addressed in age-appropriate ways throughout Sunday school. Elementary school children already learn about idol worship from other Old Testament stories, so teachers have an opportunity to contrast Genesis 1 with the idol-rich creation stories of other cultures. Middle school students can be given basic tools for considering creation and evolution such as the contrast between the “how” questions answered by their science lessons in school and the “who” and “why” questions answered in Scripture. Middle and high school students can find role models by reading the testimonies of scientist Christians.

Youth need to be encouraged to discuss their questions and doubts, while affirming core beliefs. When asked why they left the faith, scientists often mention that the church was not open to their questions and told them to “just believe.” Churches can demonstrate openness to questions by teaching youth about multiple Christian views on an issue. Students need to hear that some Christians accept the science of evolution and others do not, and have a conversation about the reasons why. Too many young people have struggled when they felt they had to choose between clear scientific evidence and the beliefs they grew up with. Even when parents and leaders are unsure about evolution, they can help students by saying, “While I have concerns about evolution, I’ve heard that some Christians accept the science of evolution while still believing in the God of the Bible.”

Difficult issues like origins cannot be addressed in a single event. People need time to ponder the issues, and spaces to talk it through. One church did a six-week sermon series, with parallel curricula for all ages in Sunday school, so that families could work through it together. Another church did a sermon series and discussion group for adults for four weeks, to prepare parents before a four-week series for the youth group. Other churches encourage small groups to read a book on science and faith and discuss a chapter a week. (Since all authors have their favorite view, I recommend discussing at least two books from different authors to learn about multiple Christian positions.)

More Than Evolution

In our science-saturated culture, evolution is not the only science topic the church should be considering, and not even the most important. With church members encountering the latest medical advances as patients and family members, a discussion on bioethics would be very relevant. Since young people are usually the first to use hot new gadgets, they should be considering the appropriate Christian use of technology . As the issue of climate change becomes more pressing every year, churches need to talk about it, and not avoid it because it is so political. The Evangelical Environmental Network offers many resources for churches, emphasizing ways that creation care benefits the poor and the unborn. One group of churches, with the help of Calvin College, joined together to clean up the local creek that drains the watershed in which the parishioners live, work, and worship. Many of the congregants were not even aware of the size of the watershed or the pollution level in their own creek. This was a hands-on opportunity for all ages, directly caring for their own corner of God’s green Earth.

More Than Controversy

With so many issues to discuss, Christians can easily get the feeling that science is always attacking the faith. It is essential to balance such conversations with positive responses to God’s creation. After all, the primary response to the natural world in the Bible is to praise the God who made it. The first time I led an adult Sunday school class on creation and evolution, I was amazed how much the participants appreciated simply ending each session with a Psalm reading or creation hymn. Thoughtful frowns turned into relaxed smiles as the group remembered our unity in Christ and the centrality of God as the Creator.

Creation themes can be incorporated throughout worship. One church asked the congregation to submit their favorite creation photos at the end of the summer (from backyard flowers to National Parks), then wove the images into a worship service with creation songs and readings from the Psalms. In addition to flowers and mountains, modern science has revealed incredible glories that can inspire our praise and reflection. Several contemporary Christian musicians have begun to artfully incorporate the wonders of the natural world into their music; Chris Rice sings of “cratered moon and Saturn’s rings,” and Third Day praises the “God of wonders beyond our galaxy.” In one church, an elder brought in modern science when leading the congregation in prayer with these words: “Creator God, out of nothing you created all that is. You hurled the galaxies through time and space. . . . The universe is your hourglass, the continental drift your minute hand, the Grand Canyon your second hand. You are infinite.”

Preachers can incorporate science in the same way they make references to movies, current events, or best-selling books in sermons. To notice these connections, take some time to encounter science: read the science section of the New York Times, visit a local science museum, or ask scientists in the congregation about their work. A visit to a planetarium might give a new appreciation for the vastness of the universe, which could illuminate a sermon on the vastness of God’s forgiveness in Psalm 103:11–12. Pastor John Van Sloten learned about the neural networks in the brain and incorporated it into a sermon on the vine and the branches of John 15.

Preachers are understandably concerned about avoiding scientific errors when preaching, but this should not prevent engagement with science. Some pastors do their own research to get the details right because they enjoy digging into a science topic. Other pastors bring in a scientist (live or by video) so that they do not have to explain the technical material themselves. Others play to their strengths by choosing topics with fewer technical details, such as the Christian motivation for doing science or exposition of Bible passages relevant for scientific questions. Many of the questions Christians have are really about biblical interpretation and Christian theology, areas where the pastor is an expert. Minor technical errors made in good faith are forgivable, but a sermon that argues that mainstream science is wrong on some point can be devastating for the faith life of teenagers who are learning the correct science in school.

Beyond Sunday morning worship and preaching, science can show up in many areas of church life. During a youth camping trip or church picnic, include a nature walk concluded with praise. After a winter evening worship service, invite a local amateur astronomer to set up a telescope in the parking lot to show people the moon and planets. Convert a vacant lot near church into a community garden, so kids can experience firsthand how God provides food from the Earth.

More Than Programs

In all these activities, remember that views on science are “caught” more than “taught.” Congregants will naturally pick up on the attitude of the pastor or ministry leader, whether skeptical of science or celebrating science as the study of God’s creation. Visitors will pick up on this too, so these attitudes are part of being a church that welcomes and ministers to scientist Christians . Recently I was invited to speak at a church on the expansion of the universe and the possibility of a multiverse. Several enthusiastic young people in attendance had clearly caught the love of science from the church leaders who planned the event. One girl came up afterward with her dad, both of them marveling at God’s creation. They were amazed not just with the particular things I had discussed, but with the way in which God has embedded wonders at every level of understanding. Everyone can marvel at the starry skies, school kids can learn about the planets and asteroids, and scientists with PhDs can study dark matter and string theory. No matter how deep we look, we keep discovering more and more ways that creation declares the glory of God.

For Further Reading

For more resources on a full range of science topics, visit the The Ministry Theorem collection at http://ministrytheorem.calvinseminary.edu/. You will find sample sermons, curricula for children and adults, worship resources, essays by a dozen scientist Christians, and much more.

There’s a serious point in my playful invocation of Pilgrim’s Progress. Like many of the most complex human endeavors — parenting, farming, becoming a Christian — the life of a scientist is not just an “occupation,” something that occupies us for a while and might then be followed by something entirely different. Being a scientist is as much about being as doing, as much about a particular way of being formed as a person as it is a set of activities or even skills. Training in science is induction not so much into a particular worldview (though it includes absorbing plenty of the kind of cognitive presuppositions that that word suggests) as it is a kind of posture or stance toward the world, toward one’s work, and toward one’s fellow human beings, both scientists and non-scientists. And the life of a scientist is a journey, one freighted with ultimate concerns and laden with values. It is a journey into a set of virtues, the habits and dispositions that make one a person of a particular kind of character.

When we talk about faith and science, we tend to focus on the cognitive content of both endeavors, the truth claims and worldviews that animate these two crucial dimensions of modern human life. These are important matters, and I don’t at all mean to diminish them. At the same time, there are inevitable limits to what any pastor can do to constructively integrate the knowledge content of science — so vast and rapidly expanding that even scientists cannot pretend to be expert in anything but a tiny portion — with the content of Christian faith. But there is another way to approach faith and science which I believe might well be more within reach of most pastors, and more essential to their job description than being deeply literate in the latest scientific discoveries and theories — and that is simply to attend to, and prayerfully support and encourage, the scientific life itself as a vocation that can reflect the image of God and be a place for working out one’s own salvation.

So here is what I wish our pastors — and fellow Christians — knew about the life of a working scientist.

Delight and Wonder

If there is one personality characteristic of the vast majority of scientists I have met, it is delight. There is something about science that attracts people who are fascinated and thrilled by the world. To be sure, any given scientist is delighted by things that you and I may find odd or indeed incomprehensible — the intricacies of protein folding, the strata of Antarctic ice cores, or the properties of Lebesgue spaces (and no, I have no idea what that last phrase really means). But the specificity of their delights is one of delight’s secrets: like love, delight is always most potent when it is particular. It is certainly possible to find lawyers who are delighted by law (I have one friend who can go on at great length, with enthusiasm, about corporate bankruptcies), dairy farmers who are delighted by cows, or lumberjacks who are delighted by trees — but I dare say your chances are much better that when you meet a scientist you will find that they are delighted with the tiny part of the world they study day to day. (At least when they are not frustrated with it — which we’ll examine below.)

In many scientists, delight is matched by wonder — a sense of astonishment at the beautiful, ingenious complexity to be found in the world. This is not the “wonder” that comes from ignorance — “I wonder how a light bulb really works?” — but a wonder that comes from understanding. Indeed, as we progress further into humanity’s scientific era we have been able to disabuse ourselves of a mistaken early-modern notion: that the more the world became comprehensible, the less it would be wonderful. That turns out not to be true at all — ask a scientist. Wonder grows as understanding grows. Indeed, wonder only grows if understanding grows. If we replace our childhood awe of lightning with an explanation like, “It’s nothing but a transfer of voltage across a highly resistive material” (an example of what G. K. Chesterton wittily called “nothing-buttery”) perhaps the world will seem like a less wonderful place. But those who actually pursue knowledge of lightning — of electromagnetism or cloud formation or weather systems or climate — end up being more in awe of the world than they were as children. This is surely one of the remarkable features of our cosmos: the more we understand about it, the more we are in awe of its beautiful elegance and simplicity, and at the same time its humbling complexity.

To be sure, many if not most scientists do not see this wonderful world in the way that most Christians would hope for. For us, wonder is a stepping-stone to worship — ascribing our awe for the world to a Creator whose worth it reveals. For many scientists, wonder is less a stepping-stone than a substitute for worship. Yet they stop and wonder all the same.

Intellectual humility

I doubt that humility is among the first traits most people think of when they think of scientists. And indeed, some scientists (like some academics and intellectuals generally) exhibit a combination of confidence in their own intellect and limitations in their social skills that makes them seem abrasive if not arrogant. A few have made a public career of intellectual overreaching, not least in matters of science and faith. But in my experience (and certainly, let me stress, in the case of my own wife!) this is much more the exception than the rule. If intellectual humility is essentially a willingness to admit what you do not and cannot know, science cultivates humility like few other pursuits can — because in few other pursuits do you so often find out that you were wrong.

Even though we tell the story of science through its high points — the discoveries and confirmed theories that won Nobel Prizes and launched new eras in technology — the actual practice of science, for nearly every working scientist, involves far more failure than success. This is especially true for experimental science, the kind that requires the most direct interaction with recalcitrant reality. On most days, in most labs, the data do not add up, Matlab has an untraceable bug, the laser is on the fritz, and all the cultures have been contaminated when the undergraduate research assistant sneezed. And while each of these everyday setbacks requires immense amounts of patience and persistence to overcome, they are only the quotidian version of the perplexity that begins early in the study of science. Every scientist, in the process of their training, has had to repeatedly discover that their intuitions about the world are simply wrong, or at least incomplete. Even great scientists have come up against the sheer oddity and unpredictability of the world — Albert Einstein, for example, never fully accepted the uncertainty at the heart of quantum mechanics, something that is now universally accepted by physicists.

This regular confrontation with the limits of one’s own knowledge and skill is not to be taken for granted. The other divisions of the academy, the social sciences and the humanities, deal with matters of such variability and complexity that it is often difficult to say conclusively that anyone, or any theory, is entirely wrong. Marx’s and Freud’s grand theories may not seem nearly as plausible as they once were, but there are thousands of people following their lines of thought without losing the respect of their intellectual peers. But Ptolemaic cosmology or Lamarckian evolution now have, simply, no followers. They have been proved wrong beyond a reasonable doubt (although Lamarck’s ideas, interestingly, turn out to have a grain of truth in a way very different from what he expected). Who is likely to be more intellectually humble — someone who early in her training, and daily in her work, learns that her assumptions have been wrong, or someone who can always argue his way out of any intellectual predicament? It is perhaps no accident that “grade inflation,” in which undergraduates’ grades ratchet ever upwards in a nod to the consumer realities of the modern university, is much less pervasive in the sciences, where you can’t cajole your way into an A. The honest, and humbling, truth is that there is likely more intellectual humility in the average physics laboratory than in the average theology classroom.

For more from the "What I Wish My Pastor Knew" series, visit The Ministry Theorem.

Such remnants are also found in our genomes.  Humans, unlike most mammals, cannot synthesize (make) our own vitamin C, but we carry the genes for synthesizing vitamin C.  One of these genes encodes the GLO (L-gulonolactone oxidase) enzyme, and this gene in humans contains inactivating mutations and is therefore a “pseudogene.”  This pseudogene and the genes that encode the enzymes of the vitamin C biosynthetic pathway are the remnants of our own evolutionary lineage from an ancestor that was able to synthesize its own vitamin C.⁴ Furthermore, the GLO pseudogene is just one of a graveyard of inactivated genes, transposons, retroviruses and other non-functional sequences that litter our genome.  While some of these sequences have been co-opted for particular functions, many of them have no known function.⁵ We share many of these non-functional sequences with chimpanzees.  The very presence of these genomic and anatomical flotsam and jetsam only makes sense if evolution has occurred.⁶

A third piece of evidence for evolution comes from biogeography.⁷ The flora and fauna of islands such as those of the Galápagos and Hawaii are radically unbalanced in that they lack many types of plants and animals but contain a profusion of clusters of similar species.  Hawaii, for example, has no native mammals, reptiles, or amphibians, but a profusion of fruit flies and silversword plants.⁸ One third of the 2,000 species of fruit flies are found on the Hawaiian Islands, which only covers 2 percent of the land on earth.  These islands were never connected to the continents and arose as a result of volcanic activity and were, at least initially, completely uncolonized.  The colonization of these islands occurred by means of occasional introduction of creatures from the mainland that then rapidly speciated on these islands to fill every available ecological niche.  Thus, the organisms most closely related to island species come from the closest mainland areas, and often include those creatures most likely to find their way to islands, such as birds and flying insects. 

The Galápagos Islands provide an excellent example of how biogeography provides evidence for evolution. The Galápagos have fourteen species of finch whose closest relative is probably the South American grassquit (Tiaris), yet only four of these finch species feed on seeds as finches normally do, while two others feed on cacti, seven eat insects, and another eats almost exclusively leaves.⁹ Darwin, while visiting the Galápagos, still thought that species only varied within a particular kind (though he would not have used that terminology) but could adapt to various local environments and become particular subspecies. Therefore, he originally listed the warbler finch (Certhidea olivacea) as a wren and listed the small cactus finch (Geospiza scandens) as a member of the Icteridae or the family of meadowlarks and orioles.  Only after Darwin had deposited his Galápagos specimens with the British ornithologist John Gould did Darwin discover (in a meeting with Gould that occurred during March, 1877), that his finch collection included thirteen or fourteen species of unusual finches that were all so closely related, Gould classified them in a single group all their own.  This meeting showed Darwin that the immutable barrier between kinds of species did not exist.  The Galápagos Islands were not a distinct “center of creation,” but a workshop for evolution in which an ancestral species made it to the yet uncolonized island and underwent a massive degree of speciation to adapt to the environment of the island.¹⁰ This is precisely what one would expect if the species of islands had arisen by evolution. 

A scientific theory also allows scientists to make predictions, and good theories provide accurate predictions.  Can the theory of evolution allow accurate predictions?  The answer, once again, is yes.  Darwin himself predicted that the earth must be very old for evolution to occur.  He did not know the age of the earth, but further research has shown that the earth is 4.55 billion years old, which is plenty of time for evolution to occur.  Darwin also predicted that since plants on islands were most closely related to certain mainland plant species, the seeds of these plants should be able to withstand immersion in sea water for long periods of time, and again, Darwin was shown to be right.¹¹ Many decades after Darwin, we now know that variation in organisms is due to mutations in DNA and that these mutations are inherited, just as Darwin predicted.¹² Also, Darwin’s principle of natural selection predicts that particular sequences of DNA should behave in a manner that benefits only themselves and not their carriers, which modern research has thoroughly confirmed with the discovery of transposons and other types of “selfish DNA.”¹³

Is evolutionary theory a good scientific theory?  It has been repeatedly tested for over 150 years since its inception, and it has passed those tests successfully.  The theory has been modified in response to new data, but the outlines of the theory have remained largely intact.  It has existed at risk from new data.  During the molecular biology revolution that began with the discovery of the structure of DNA by Franklin, Watson and Crick in 1953, the explosion of new data could have shown contemporary evolutionary theory to be wrong.  However, some of the most powerful evidence for the theory of evolution has come from a field of science that did not even exist during Darwin’s time.  The ability of a theory to withstand such intense scrutiny is a clear sign it is robust and enduring.  As shown, the theory of evolution has predictive power, and it also integrates and makes sense of data from several fields of science, including ecology, paleontology, genetics, historical geology, paleoclimatology, and comparative anatomy and biochemistry.  The highly integrative nature of evolutionary theory makes it a fine theory by any measure. 

In conclusion, when measured against the standards of a good scientific theory, modern evolutionary biology clearly qualifies as good science.  Ongoing debates within evolutionary biology exist about mechanism, rates, and causes, but not over whether evolution occurred.  Such a question has been largely settled by the last 150 years’ worth of research.  The future certainly looks bright for this field of science and I cannot imagine a more exciting topic to study. 

Notes

1. Davit-Béal, Tiphaine,Abigail S. Tucker, and Jean-Yves Sire. “Loss of Teeth and Enamel in Tetrapods: Fossil Record, Genetic Data and Morphological Adaptations.” Journal of Anatomy 214, no. 4 (2009): 477–501. 

2. Tian, Natasha M. M.-L., and David J. Price. “Why Cavefish are Blind.” BioEssays 27 (2005): 235–38; Yamamoto Y, Stock DW, and Jeffery WR (2004) Hedgehog Signalling Controls Eye Degeneration in Blind Cavefish. Nature 431:844–7; Jeffery, W. R. “Adaptive Evolution of Eye Degeneration in the Mexican Blind Cavefish.” Journal of Heredity 96, no. 3 (2005): 185–196. 

3. Bejder, L., and B. K. Hall. “Limbs in Whales and Limblessness in Other Vertebrates: Mechanisms of Evolutionary and Developmental Transformation and Loss.” Evolution and Development 4, no. 6 (2002): 445–58. 

4. Lachapelle, M. Y., and G. Drouin. “Inactivation Dates of the Human and Guinea Pig Vitamin C Genes.” Genetica 139, no. 2 (2011): 199–207.

5. Avise, John C. Inside the Human Genome: A Case for Non-Intelligent Design. New York: Oxford University Press, 2010.   Romano, C. M., F. L. Melo, M. A. Corsini, E. C. Homes, and P. M. Zanotto.  “Demographic Histories of ERV-K in Humans, Chimpanzees and Rhesus Monkeys.” PLoS One 2, no. 10 (2007): e1026. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001026. 

6. Max, “Plagiarized Errors and Molecular Genetics,” http://www.talkorigins.org/faqs/molgen.

7. Coyne, Jerry A. “Intelligent Design: The Faith that Dare Not Peak Its Name.” In Intelligent Thought: Science Versus the Intelligent Design Movement, edited by John Brockman, 3–23. New York: Vintage, 2006. 

8. Kricher, John. Galápagos: A Natural History. Princeton, NJ:  Princeton University Press, 2006. 

9. Grant, Peter R., and Rosemary B. Grant. How and Why Species Multiply: The Radiation of Darwin’s Finches. Princeton, NJ: Princeton University Press, 2011. 

10. Sulloway, Frank J. “Why Darwin Rejected Intelligent Design.” In Intelligent Thought: Science Versus the Intelligent Design Movement, edited by John Brockman, 107–25. New York: Vintage, 2006. 

11. Darwin, Charles. “On the action of sea-water on the germination of seeds.” Journal of Proceedings of the Linnean Society of London (Botany). 1 (1857): 130–140.

12. Futuyma, Douglas J. Evolution. 3rd ed. Sundbury, MA: Sinauer Associates, 2013. 

13. Dawkins, Richard. The Selfish Gene. New York: Oxford University Press, 2006.

"Anyone approaching the Resurrection accounts in the belief that he knows what rising from the dead means will inevitably misunderstand those accounts and will then dismiss them as meaningless" (p. 243).

In fact, if Jesus' Resurrection were "merely" coming back to life in any way that we might comprehend, then it would be of little significance.

"Now it must be acknowledged that if in Jesus' Resurrection we were dealing simply with the miracle of a resuscitated corpse, it would ultimately be of no concern to us" (p. 243).

So what then does Resurrection mean? For Benedict it represents a new dimension of reality breaking through into human experience. It is not a violation of the old; it is the manifestation of something new.

"Jesus had not returned to a normal human life in this world like Lazarus and the others whom Jesus raised from the dead. He has entered upon a different life, a new life -- he has entered the vast breadth of God himself..." (p. 244).

Because it is something entirely new, it cannot represent a violation of natural law as understood by science.

"Naturally there can be no contradiction of clear scientific data. The Resurrection accounts certainly speak of something outside our world of experience. They speak of something new, something unprecedented -- a new dimension of reality that is revealed. What already exists is not called into question. Rather we are told that there is a further dimension, beyond what was previously known. Does that contradict science? Can there really only ever be what there has always been? Can there not be something unexpected, something unimaginable, something new? If there really is a God, is he not able to create a new dimension of human existence, a new dimension of reality altogether?" (p. 246-7)

Thus, in this view, Resurrection (as with all true miracles) is not contrary to science, but an indicator that science does not (yet?) describe the full expanse of reality. Indeed, some may argue that science itself contains similar "indicators." The 11 (or so) dimensional universe required by some versions of string theory, the multiverse theory of the universe where ours is but one of an infinite array of universes with variable physical laws, quantum entanglements, "spooky" action at a distance, the mysterious emergence of consciousness from inorganic matter -- all push the limits of human reason and imagination, suggesting to some that reality may be far more complex than the human mind can grasp.

For a moment, let us entertain the possibility that Resurrection is as Benedict interprets it: not a violation of natural law but an indicator of something beyond our scientific understanding of the universe. This has interesting implications for understanding how believers and skeptics approach the issue. If Resurrection does not violate science, then science does not necessarily constitute an impediment to accepting the reality of Resurrection. If the difference between the skeptic and believer is not science, then is it just a matter of imagination? The believer imagines greater possibilities for the universe than the non-believer. While this is possible, it seems questionable. To my knowledge, no research has found differences in imaginative abilities between religious and non-religious people. Moreover, contrarian examples easily come to mind: Isaac Asimov was an atheist but hardly lacking in imagination when it came to science fiction. I tend to think that both believers and non-believers can imagine (with varying degrees of effort, I'm sure) the new possibilities implied by Resurrection.

Thus, if it is neither imagination nor science that prompts skepticism about Resurrection, then what is left? I suggest that it comes down to a question of authority: At what point does one allow imaginative possibilities to have authority over how one lives? To the believer, Resurrection has an authority that science fiction does not. Resurrection is not thought-provoking entertainment. It requires far more than just imagining greater possibilities for the universe. It requires a change of life, here and now. Unlike the microscopic hidden dimensions of string theory, the new dimension implied by Resurrection has "broken though" into everyday reality and demands a response -- even if that response is to actively ignore it.

Now, what convinces the believer that Resurrection merits such authority when other imaginative possibilities such as extraterrestrial life or time-travel do not? The answer here appears to be historical commitment. There's no record of people committing themselves to the point of martyrdom to other imaginative possibilities as they have to Resurrection. The earliest example of such commitment being found, of course, in the dramatic post-crucifixion turn-around of the Apostles. Such an astounding change of heart, followed by an unwavering commitment capable of altering human history demands a categorically unique explanation: Resurrection.

The believer's argument, however, remains unconvincing to the skeptic. However impressive they might be, a change of heart and steadfast commitment do not necessarily add up to a new dimension of reality. Extraordinary claims require extraordinary evidence. Fair enough. So a key question regarding the interpretation of Resurrection is this: Is the post-crucifixion history of Christianity extraordinary? Does it compel the dispassionate observer to concede that a categorically unique event could plausibly be its best explanation?

It ought to be upon questions such as those above that skeptics and believers respectfully engage one another, rather than the simplistic and often acrimonious sloganeering that has increasingly become the norm.

JIMMY LIN: Currently I’m on faculty at Washington University at St. Louis, where I am a research instructor in the pathology department. Also, a year and a half ago, I founded the Rare Genomics Institute (RGI)—a nonprofit that helps find cures for people with rare diseases.

ER: What qualifies as a “rare disease”?

JL: These are diseases like cystic fibrosis and Huntingdon’s disease—diseases that affect less than 200,000 Americans each year. There are over 7000 different rare diseases, and less than 5% of them have any therapy. Altogether, they affect about 25-30 million people.

This creates what we call a “long tail problem”—it’s hard for a top-down research system to create research programs for all 7000 rare diseases. So instead, we are creating a bottom-up platform from which the patients themselves can create research projects and help fund them. We connect patients with physicians and researchers, customize a research program with top medical universities, design the experiment, and then use an online fundraising platform to fund the study through [mostly] friends and family of the patient.

Basically, we create a “foundation in a box.” By partnering with the Rare Genomics Institute, patients and their friends and families who want to study rare diseases don’t have to go through the hoops of creating their own nonprofit or lab—we do that for them. So, instead of creating 7000 different nonprofits, we create a generalized platform from which studies can be conducted.

ER: Who qualifies for care through the Rare Genomics Institute?

JL: Anyone with a rare disease can come to us. The main thing we’re doing right now is diagnosis. When families come to us, they either don’t know the disease that’s affecting them or their child, or they don’t know the gene that’s wrong.

For instance, if a child had a condition that doctors couldn’t identify, his or her parents might come to us for help. What we’d do then is sequence the genes of the mother, father, and child, and compare them to reference genome to determine what mutations each of the parents have. Depending on what the disease is and what the gene causing it is, we can filter out mutations that don’t mean anything using the parents’ genomes—then, after filtering, we can potentially pinpoint the genes that fit the genetic pattern of the disease. This is the first step.

After that, we are building infrastructure to determine the effect of these changes and a way to help. For example, after looking at the literature, we can perhaps design experiments using cells extracted from the patient; this part of the process is different for every disease. Then, if we can determine that there is, for instance, a pathway missing a specific enzyme, we can try using drugs, a bone marrow transplant, or gene therapy to try to put healthy cells into the child… But there’s a variety of diseases, of course, so there’s a variety of different approaches—and we’re just starting to explore these aspects.

ER: How did RGI get started?

JL: It really started when I was in medical school at Johns Hopkins—there was this boy that came to our clinic to be seen. My research was in cancer genome sequencing, and the family had come to our department looking for answers about what was wrong with their son. At that point, the family was almost hopeless—they had gone to so many doctors, run so many tests—I decided I wanted to try to help children like this. That’s when my friends and I decided to start the Rare Genomics Institute.

Currently, there are about 50 researchers associated with the organization, and we are all volunteers. It’s growing much, much faster and been more amazing than we’ve ever imagined—we’re already making an impact. In May of last year, we were able to discover a new disease using the world’s first crowd-sourced, crowd-funded genome. Working with researchers at Yale, we delineated a disease of which our patient was the first identified.

Right now, we’re in the middle of raising funding and hiring staff to make this organization one that is self-sustaining, and to increase its impact even more.

Excerpts from Michael Hickerson Interview

MH: …you call yourself a doxologist. What’s the full term you used in your Jubilee bio?

JL: Medical and scientific doxologist.

MH: How did you decide on that term and what does it mean to you?

JL: I listen to a bunch of teaching by J.I. Packer , who teaches theology at Regent College and is one of the leading thinkers on these things. Interestingly, before any one of his classes, he says “Theology is for doxology,” and then the whole class sings the Doxology together out loud in class. I thought, “Wow, that is so great,” because everybody sometimes learns theology just for intellectual things [instead of for worship].

That’s not just true for theology, it’s for everything: biology is for doxology; chemistry is for doxology. That’s when I started to think, I should consider myself, first and foremost, as a person who praises God in what I do. And then no longer make “Christian” the adjective, right? “Doxologist” is the noun. But then what kind of doxologist am I? So I call myself a medical and scientist doxologist. I would call someone, for example, in the marketplace, a business doxologist. Or, someone who does art, an artistic doxologist. To really have the noun as our identity, and then our vocation as just a descriptor of how we do that.

MH: That’s a great point. A noun is always stronger than the adjective. So, you want that to be the focus, rather than the add-on.

JL: In our current culture, we’re defined by our jobs. It’s having a vocation. I wanted to shift away from that. I didn’t want to be a doctor first and foremost, or a scientist, but one who praises God. And evidently, within science you don’t want to call yourself a Christian Scientist. That’s another religion, so . . .

MH: [laughs] That’s right. I run into that, as well, when I’m teaching or talking about science to Christians. You always run into that stumbling block.

JL: With “scientific doxologist,” people don’t confuse them. You do have to explain what it means. And that gets in a little story actually, on what it means about vocation. It’s a small lesson — a teaching point when you do talk to people about vocation and calling. That’s why I use it.

MH: I guess my final question would be what spiritual practices help sustain you? What helps you stay in contact with God and keep a good foundation?

JL: First, I am interested in many, many different things. I sort of mix it up in terms of spiritual practices. Besides the fundamentals, of course, of quiet time, devotional reading, and scriptural reading, I do theological study because I have to do that academically. I find a lot of time with God through the spiritual disciplines, such as times of solitude — which is very interesting for someone who is in academics to no longer think about ideas but just to be quiet before God — how silence, time to think by yourself, or sitting in silence is also something you should foster.

In terms of spiritual formation, what you really need is definitely a good community of people. I have a very supportive community at my church. I’m the deacon of devotions, so that of course keeps me on track. It encourages me as I, in my own spiritual walk, encourage other people. Fundamentally, I think for all Christians, whether you are academic or no matter your vocation or calling, being in the Word and prayer are the most important things. Doing that and being spiritually fed is what is important.

DOUG LAUFFENBURGER: It could look like a lot of things. One way to envision what I mean is to put yourself back a hundred years. For instance, in 1913, an electronic computer was unimaginable. But using physics, quantum physics, leading to semiconductors and devices like that, people figured out over the next 20 to 30 years how you could build a machine to do calculations and so forth. And then, of course, all sorts of thing happened…

We’re roughly at that stage with biology, even though it seems like things are more imaginable because—and we don’t have to go strictly century by century here—because we can already guess the way some things might change, whereas in 1913 there was no inkling, really, as to what would happen in the computer revolution.

So, to enumerate some of the things that are conceivable—let’s just start with computers, because we were just there.

There’s a notion that computers get faster and cheaper by making their logic gates smaller, and how you improve a design with physics keeps bumping up against how you make these little units smaller. Well, using biology, the solution seems self-evident—you just line up the pieces of DNA, and if you put the right pieces of DNA in the right places, the resulting parts are so much smaller than the things we can do with physics. You can imagine, even though it’s just a theory now, computers continuing to become many times smaller and cheaper—and be made via environmentally benign manufacturing processes—through biomolecular construction.

Now that’s exciting from one point of view, but from another, it’s not that revolutionary, because you’re just using DNA as a piece of physics. It’s not really biology—it’s merely a biological molecule being used to make better physics.

For a different example, if you think about the way we make things, the way we manufacture plastics, gasoline, energy—we have to do all that using chemistry, and to make that chemistry happen, we have to input a lot of energy—in fact, one of the most costly industries in terms of energy usage is the energy industry. You have to put in so much energy to refine petroleum and things like that. And to make plastics, ceramics—things of that nature—is also very energy intensive, and it’s also where a lot of pollution comes from, because you’re mixing together all these chemicals that really didn’t want to be mixed together. You get what you want, but you get a lot of byproducts, toxins, etc.

Well, people have started to realize that a lot of this work can be redone through the use of biology. You can turn corn into fuel or plastic, and you can make magnetic or electrical storage devices out of biological units (viruses can pattern the crystals, so instead of using mixtures of toxic chemicals, you just pull the viruses with the right properties together). Right on this tabletop, you could make materials that by current manufacturing processes would otherwise cause a great amount of environmental hazard.

As for another exciting development—well, to preface, one of the problematic things about modern agriculture is the necessity of using fertilizers (there are insecticides to be concerned about, too), but fertilizer manufacturing is terrible for the environment. You have to make fertilizer out of ammonia and that’s a horribly polluting and energy-intensive manufacturing process. What you could potentially do, instead, is program into bacteria the genes that take nitrogen out of air, turning it into organic nitrogen then just scatter the bacteria onto the field—and you wouldn’t need to make ammonium using the current very caustic processes.

These are the sorts of things I mean—and we haven’t even touched on medicine, yet. People tend to think about medicinal advances, first, but before you even get to medicine, you can think about energy, manufacturing, materials, and agriculture. In 50 years, we should be able to do things in ways we don’t do them now, that will be cheaper, less toxic, less polluting, more efficient, and so forth.

ER: A lot of people are nervous about the idea of “programming” life. Can you respond to this fear as a Christian?

DL: As a Christian, I would say that God gave humankind dominion over the earth, to do good things—he gave us minds, a passion for understanding how things work, and then he put in this world all these fascinating processes, which, if we figured them out, we could do good things, could feed more people—could feed more people without causing extensive damage to the environment. And cure disease and injury. And the list goes on. I think all that is good, and that God would be pleased that we would be using His creation to live better—I’m not saying more luxuriously, but more happily, contentedly, with each other.

ER: But back to the topic—advances using biology in the next century. You had just mentioned medicine…

DL: So, yes, there’s also medicine. Now, obviously, in thinking about this, the use of stem cells comes to immediately the fore. There are a lot of diseases out there that you really do need to correct using cellular processes. Right now, we try to make these corrections through chemistry. For instance, we give you a pill, and that pill should interfere with something that’s going wrong in your body—and yet it’s really never adequate to just interfere with something that goes wrong in the body, because you don’t really set it right just by getting in the way of it.

The opportunity with stem cells is that you can say, “I’ll replace the cells in the body that are doing something wrong with cells that are actually doing it right again.” If you program cells to be neurons, heart cells, or bone cells, you can regenerate properly functioning physiology. Rather than, say, replacing a hip with a metal part, you could regenerate the bone, itself, or you could regenerate neurons in Alzheimer’s patients. Never in the past has medicine been able to regenerate a proper physiology; it’s only tried to replace it with an inadequate surrogate, or minimize how much damage a disease is doing. With the use of stem cells, you can actually imagine returning the body to its proper physiology.

A different use of stem cells is to generate human tissue in the laboratory for better studies of human physiology and pathology and improved testing of drug effectiveness and toxicity.  This will be a major advance over animal models, because of the significant disparities between animal physiology and human physiology.

A key point to emphasize is that there are different kinds of stem cells, which involve big differences in potential concerns. For Christians, clearly, stem cells derived from embryos present a tremendous ethical issue. Fortunately, a good proportion of stem cell technologies can be pursued using stem cells from adult tissue. These cells can be stimulated to develop into certain tissue-specific physiological behavior, or can now even be “re-programmed” to become quite similar to the more broadly flexible stem cells derived from embryos but now not requiring the embryonic source. Happily, the days of reliance on embryo-derived stem cells appear to be over for purposes of beneficial technologies.

We also should consider genomic medicine, and what’s attractive about that field is that with the way we do medicine now, which is chemistry-based—say you have a disease, and we might give you a pill to correct it—well, the biggest problem with that is that while I think this pill will help ameliorate your condition, maybe it won’t. Maybe that drug only works in ten percent of the patients and not ninety percent.

For example, consider cancer. You’ve got a particular kind of cancer, and we prescribe a certain treatment… well, hopefully you’re among the lucky ten percent, and you’ll be in much better shape in two or three years. If you’re not, then we’ve wasted your time. In fact, we’ve probably hurt you rather than helped you, because we’re using chemistry to interfere with things, and even though we might be reducing the damage of some things, we’re probably causing toxicity elsewhere in the system, because that same chemistry is also interfering over there.

So the value of genomic medicine is to get enough information about you through sequencing your genome that we can say, “Ah, for you this particular pill is not a good idea; it will actually do more damage than good. But for your brother, it’s likely to work, and the ratio of benefit to harm is much better.” This is the reason genomic medicine is more imminent—it’s what’s closest on the horizon to being realized—because we can use the same drugs we have now, we’ll just be using them more effectively. At the moment, we can sequence genomes, and we do have these treatments that help, and it’s just a matter of matching up these two technologies.

Now, on the other hand, when you think about genome sequencing, you can find out all sorts of things, and you have to decide, “What if I learn something negative?”

EDITOR’S NOTE: Join us next week as we continue the conversation about genomic medicine, bioengineering, and being a Christian in science.

By Luci Shaw

Blessed be God for thaw, for the clear drops
that fall, one by one, like clocks ticking, from
the icicles along the eaves. For shift and shrinkage,
including the soggy gray mess on the deck
like an abandoned mattress that has
lost its inner spring. For the gurgle
of gutters, for snow melting underfoot when I
step off the porch. For slush. For the glisten
on the sidewalk that only wets the foot sole
and doesn’t send me slithering. Everything
is alert to this melting, the slow flow of it,
the declaration of intent, the liquidation.

Glory be to God for changes. For bulbs
breaking the darkness with their green beaks.
For moles and moths and velvet green moss
waiting to fill the driveway cracks. For the way
the sun pierces the window minutes earlier each day.
For earthquakes and tectonic plates—earth’s bump
and grind—and new mountains pushing up
like teeth in a one-year-old. For melodrama—
lightning on the sky stage, and the burst of applause
that follows. Praise him for day and night, and light
switches by the door. For seasons, for cycles
and bicycles, for whales and waterspouts,
for watersheds and waterfalls and waking
and the letter W, for the waxing and waning
of weather so that we never get complacent. For all
the world, and for the way it twirls on its axis
like an exotic dancer. For the north pole and the
south pole and the equator and everything between.

Editor's Note: If you'd like to see other great posts like this, go to the BioLogos Navigator topic Worship & Arts.

About a year ago I posted the first article in this series, asking whether recent advances in genomics made any difference to the Judeo-Christian notion of humanity being made in the 'image of God'. That article focused on DNA sequencing data from our closest relatives. This article will focus on the issue of genetic determinism.

Theologians have spent many centuries mining the rich vein of the 'image of God' metaphor. Central to the idea is humanity with spiritual capabilities and responsibilities, equipped for moral decision-making and a relationally rich life in community. Historically, the idea has contributed to the conviction that each human individual has an absolute value, independent of their ethnicity, educational level, health status or income.

Do recent advances in genomics threaten or support such a view of humankind, or are they just neutral? Irrespective of one's belief in God, or not, this is of more than passing interest. Imagine the poor person wrestling for years with the great questions of life and finally deciding to become an atheist, only to then be informed that a cognitive bias derived from his particular set of genetic variants made that decision pretty much inevitable anyway. Such news might be equally unsettling for the person who had just struggled to faith following years of agnosticism. Our deepest human feelings are closely connected with the idea that we choose our own path through life.

The flourishing of genomics in the early part of the 21st century has certainly conveyed the message to many that one's destiny is written into one's genome. Whereas scientists are generally scrupulously careful not to give the impression that there is any such entity as a "gene for" some human trait, by the time the latest discovery appears in the media, such caution is often thrown to the winds. The past year has seen the trumpeting of a "gene for happiness," a "kindness gene" and a "believer gene." It is not even a question of education, but "genes are to decide" if you are a "caring person." Genetic testing websites assure us that "your genes are a road-map to better health," and we all know that road-maps are fixed. Small wonder that there is a creeping genetic fatalism around that subverts the idea of personal responsibility.

Fatalism in itself impacts on human behavior. Studies have shown that subjects exposed to the writings of authority figures doubting free-will are then more likely to cheat. Conversely, workers convinced of the reality of free-will are rated higher in the work-place than those whose beliefs tend more towards determinism.

The reality is that recent genetics research has continued to move steadily away from any notion of genetic fatalism, highlighting the sheer complexity of the genome, and providing some fascinating examples of the ways in which our choices impact upon our own genomes. There is no gene "for" any complex human trait because in fact genes encode proteins or other types of information-containing molecules, and thousands of genes collaborate together during human development in interaction with the environment to generate the unique human individual that each person represents. Those requiring an introduction for the non-specialist are referred to "The Language of Genetics."

Epigenetics adds further layers of variation and complexity. This refers to the chemical modifications of the DNA that cause genes to be switched on or off. It is such epigenetic modifications that generate the 220 specialized tissues of our bodies. Such acquired changes can even be inherited across several generations, certainly in plants and animals, and maybe in humans as well. In choosing to smoke, drink in excess, or take drugs, we also choose to modify our genomes.

So it turns out that even identical twins are not really genetically identical, developing different profiles of epigenetic modification as they go through life. This no doubt contributes to the otherwise surprising result that the age of death of identical twins, who share identical genomes, is comparable with that observed in non-identical twins, whose genomes are as different from each other as any two sibs. In one study of 184 pairs of twins in Spain, the difference in the age of death between the identical twin pairs was seven years on average, but such averages hide the fact that the age differences ranged from a couple of weeks to eighteen years. In the case of the non-identical twins, the difference in age at time of death was nine years, and the range was three to nineteen years. So there was really not that much in it.

What would happen if there was a genetic marker that identified nearly everyone in prison, marking them out as genetically distinct from half the world's population? What would that do to our ideas about genetic fatalism and convictions about moral responsibility? As it happens that marker already exists. Out of 131 countries worldwide, an average of 96 percent of the prisoners are male and, in this case, no complicated genetic studies are needed to know that the genetic marker that identifies this population is the Y chromosome. So universal is the correlation between the Y chromosome and criminality that we can safely say that no other genetic correlation will ever be found between a variant genome and criminality that surpasses this one. And yet we still hold nearly all males responsible for their criminal actions and put them in jail as soon as they're convicted. Furthermore, we note that most people who possess a Y chromosome go through life without committing a crime. So having a Y chromosome, with its unique set of genes, does not "determine" human criminality, although clearly we cannot go to the opposite extreme and say that it is completely irrelevant for patterns of human behavior.

The point in citing such examples is not to suggest that our genomes have nothing to do with our lives. They certainly do, not least in their significant contributions to our personality differences. The point rather is that the latest results in genetics provide no grounds for fatalism, instead highlighting the richness and diversity of the human population, and our own moral responsibilities, including the challenge to be good stewards of our genomes.

An argument for the existence of God this is not. But for those of us whose world-view is shaped by the conviction that we humanity are made in God's image, it is good to know that the latest genetics is consistent with such a perspective.

Werner Heisenberg, in a letter to Albert Einstein¹

For many people, science invites awe and religion invites insight. When awe and insight engage, science-and-religion happens.

Ron Cole-Turner²

If we can understand the experiences of the people who work every day in the lab, our dialogues concerning science and religion will be far more fruitful than they would be otherwise. I realised this when someone recently asked me what the highlights had been during my own time as a biologist. I explained that what I appreciated most was the privilege of experiencing science first-hand. My horizons have been expanded, and I now have a better understanding of how vast and complex the natural world is. Appreciating the grandeur of the universe seems to be a universal for humankind, including research scientists in their own peculiar way. Everyone has something to add to a conversation about experiences of awe, as I discovered when I blogged on it recently and invited a number of friends and former colleagues to comment. This sense of awe is a perfect starting point for discussions of science and theology.

Life in the Laboratory

I had always loved finding out how things work, and that was one of the reasons why I chose biology, but actually working ‘at the coal face’ was an eye opener. Living organisms are extremely complicated, so one has to choose only a tiny part of an organism to study: maybe a single gene or a feature of its behaviour. It can take years to understand just one aspect of that tiny part in enough depth to be able to publish an academic paper about it. Experienced scientists describe how the sum of human knowledge is so small as to be insignificant in comparison to what is out there, and I can now appreciate that a little bit. I can also appreciate what fun it is to survey all that un-knowledge, grab a bit of it and try to figure it out.

In the world outside of the lab we hear the headlines about new discoveries, but we have no idea what is behind that one-liner. In reality the story of a discovery in biology may well have started with a graduate student who nervously began their new project, a more experienced scientist who sacrificed precious time to train and supervise them, and the lab head who looked over the data every now and then. There would have been long days and nights in the lab and many false turns before the first piece of promising data emerged. No doubt there were anxious re-runs of experiments to confirm the results, and moments of elation as things started to make sense. The work would have been presented to critical colleagues who suggested further experiments. Frustrating months would have been spent generating the final pieces of data, weeks bent over a computer writing a dense and meticulously referenced paper, submission to a journal, the referees’ criticisms, a few more experiments, resubmission, and a long wait. Finally the paper was accepted and the whole research group joined in the celebration. And this is only the simplest possible version of events – the process of producing successful research can involve large numbers of people over several years, international collaborations, promising leads that go stale, and surprising results from unexpected places.

The ‘real world’ of science is a million miles away from the debates on science and religion that happen in churches, universities and schools throughout the world. Behind every piece of research is a team of people representing different faiths and belief systems, a variety of cultures, social backgrounds and personality types. Perhaps scientists are all a little crazy (who would put in the hours otherwise?), but they’re definitely all motivated in different ways.

The factors that attract people to science are many, though inspiring and supportive parents or teachers can play a large part. The reasons why individuals decide to stick with research, despite all the demands and uncertainties that a life in science brings, are interesting and at times surprising. There is the fascination of understanding the natural world, the value of original research, the prospect of new technologies further down the line, and the privilege of making new discoveries. There is also the opportunity to ask new questions, and the immense satisfaction when things come together and begin to make sense. So far, so predictable. More unexpected drivers are the enjoyable process of tinkering with experimental systems, the opportunity to exercise great creativity, the beauty of scientific data, and a feeling of immense awe when one gets a rare insight into the way the world operates. The rewards for doing science range from the utilitarian to the downright spiritual.

Awe in Science

Awe is an important part of the experience of science – one could almost say it’s a universal. When a scientist feels awe it is usually in response to something complex, precise, ordered, powerful or beautiful. There is an element of unexpectedness and delight, maybe even respect, fear or reverence. Awe always involves the need for some sort of mental adjustment or accommodation: we need to make room in our internal map of the world for this new and amazing experience. The physicist Werner Heisenberg vividly described this process of taking on board a startling new concept when he wrote of his discovery of atomic energy levels:

“In the first moment I was deeply frightened. I had the feeling that, through the surface of atomic phenomena, I was looking at a deeply lying bottom of remarkable internal beauty. I felt almost giddy at the thought that I had now to probe this wealth of mathematical structures that nature down there had spread before me.”

Moments of awe are the rare high-points in science, both rationally and emotionally. Finally something is understood. That understanding and the new possibilities it opens up are wonderful, and the story is told and retold. Scientists, as you might expect, respond scientifically, with new questions and investigations. But they also respond in other ways depending on their personalities: aesthetically, using visual representations of the data in different ways; philosophically, as they discuss the ethical implications of the research or the surprising intelligibility of the universe; or spiritually, as they try to make sense of those feelings of awe and wonder at the immensity and beauty of the world.

When Elaine Howard Ecklund carried out some research into the beliefs of scientists in elite US universities, she discovered a surprising fact: 20% of the people that she and her research team spoke to were not members of any religious group, but considered themselves spiritual. For some of these scientists the experience of beauty, awe and wonder in their work led them to believe that there is something beyond science – one could perhaps call it ‘transcendent’ – an experience that motivated some of them in their research, their teaching, and their lives outside of the lab. I remember having a conversation with a colleague who had experienced something along these lines, so I’m not surprised to hear that many others feel the same.

According to the scientist-theologian Alister McGrath, experiences of the transcendent might involve a sense of the ‘numinous’ – a feeling that something ‘other’ might be behind what one is seeing. Or perhaps someone might encounter a deep truth about the unity of reality that strikes them in a particular way. Perhaps more common would be a moment of unexpected clarity – what some might call an epiphany – where suddenly things make sense. Experiences that might be called ‘transcendent’ are rare, but they leave a lasting impression.

The language used by many scientists when they describe the process of discovery is of a reality that was always there. Perhaps it’s not surprising that scientists are ‘realists’; they think that there is a real world outside of ourselves that waits to be discovered. Science does not answer the ultimate questions about the universe, but scientists are human beings so we just ask those questions anyway – sometimes looking for answers in unexpected places.

Spirituality in Science

At the beginning of this piece I mentioned my growing realisation of the size of the scientist’s task. The seeming inexhaustibility of the created order can be overwhelming, but many see this as something positive. There is so much more to explore. As the Jesuit philosopher Enrico Cantore has said, the mystery of the universe lies not in ignorance, but in dazzling intelligibility. Where do these thoughts of transcendence, reality and mystery lead? For Einstein, they were a religion. A Mind other than our own was somehow responsible for this world that we can make sense of using the language of mathematics. For others, the reality we see in the world leads to ideals that transcend differences of language, culture and religion.

We search for meaning, and we long for more. CS Lewis famously describes the world we live in as a pale reflection of the one to come.³ For those who already believe in God, what we see in science makes sense. We live in a world that operates according to principles that we can understand and describe mathematically. We can utilize what we find for good or evil (and everything in between), and what we discover is both beautiful and awe-inspiring. William Whewell, the nineteenth-century polymath and Master of Trinity College, Cambridge, said that ‘We must find the right thread on which to string the pearls of our observations, so that they disclose their true pattern.’

For me, what we see in science is not evidence for God, but works well as a thought experiment. What would you expect if God existed? In the context of faith, science increases my sense of awe and wonder and helps me to worship God in a more genuine way. The Christian songwriter Matt Redman said that we sometimes ‘take the extraordinary revelation of God and somehow manage to make Him sound completely ordinary’. Science has the power to expand our horizons and helps us to see how great God is. The dazzling intelligibility of the world increases our humility, as we realise that because we ourselves are a fragile and finite part of the universe, we will never be able to fully grasp what we see in an objective intellectual way.⁴ Our response to what we see in the world is rational, emotional and active: worship as well as systematic theology.

The highest mountain peaks and the deepest canyon depths are just tiny echoes of His proclaimed greatness. And the brightest stars above, only the faintest emblems of the full measure of His glory.⁵

Notes

The main sources for this piece are Enrico Cantore, Scientific Man: The Humanistic Significance of Science (New York: ISH Publications, 1977); Olaf Pedersen, “Christian belief and the fascination of science” in Physics, Philosophy and Theology: A Common Quest for Understanding, Eds. Robert John Russell, William R. Stoeger & George V. Coyne. (Vatican City State: Vatican Observatory, 1988), 125-140.; Alister McGrath, The Open Secret (Oxford: Blackwell, 2008).

1. From Enrico Cantore, Scientific Man: The Humanistic Significance of Science (New York: ISH Publications, 1977)

2. Ron Cole-Turner, ‘What Do You Find Most Interesting or Surprising About the S&R Discussion Today?’, Science & Religion Today, 21st May 2012, http://www.scienceandreligiontoday.com/2012/05/21/what-do-you-find-most-interesting-or-surprising-about-the-sr-discussion-today-ron-cole-turner-answers/

3. In C.S. Lewis, The Weight of Glory. SPCK, 1942

4. Jame Schaefer, Theological Foundations for Environmental Ethics: Reconstructing Patristic and Medieval Concepts (Washington, DC: Georgetown University Press, 2009), Chapter 1.

5. Matt Redman, Facedown (Eastbourne: Survivor, 2004).

Today, as I write, I am no longer in the desert of southern California, nor in the beech-maple forest of New Hampshire, but on a glacial drumlin in Waubesa Wetlands—a large marsh four miles south of Madison, Wisconsin. Here Ruth and I have our home, and here I study creatures whose watery habitats my neighbors and I have worked to save from eventual destruction. While my desert study site now is covered by a city where people live alone in the land—absent the desert creatures—my wetland study site remains occupied by all kinds of native plants and animals. Embracing it is the Town of Dunn, whose land stewardship plan helps people understand, serve, and maintain this and the other ecosystems. Our town stewardship plan encourages restoration of the landscape, protects agricultural lands, and strives to transmit an intergenerational heritage of secure and wholesome homes, livelihoods, and habitats for the animals, plants, and people that live here. We live largely in harmony and accord.

House-building on slabs poured onto desert sands first alerted me to the question of praxis, the third point on the napkin. But it was later, in my work as organizer of the Waubesa Wetlands Scientific and Agricultural Preserve, and as supervisor and later as chair of the Town of Dunn, that I came to realize that science and ethics do no earthly good unless put into practice. In serving my town, I came to apply what I had learned in the desert: praxis uninformed by science and ethics usually creates more problems than are solved.

“How do you put it all together?” those students in New Hampshire wanted to know. For me, it was building a framework for stewardship that simultaneously considered the questions “How does the world work?” “What is right?” and “What then must we do?” This science-ethics-praxis triad is a framework for living, for learning, for teaching, and most importantly for acting. It is a framework for stewardship.

In order to live and act rightly in the world, we need to know how the world works. We need to know how the systems that sustain us work, and how we interact with them. Without such knowledge we could drown in a flash flood, have our homes undercut by desert winds, cross the street in the path of an oncoming car, or get sick from consuming foods with toxic ingredients. As human beings develop more and more of the world, and as the reach of human actions extends regionally and globally, our knowledge must increase accordingly. This knowledge is not limited to what we acquire from a formal education; it also includes the knowledge we gain from family and friends, and from experience and experiment. In order to live and act rightly in the world, we need to know how the world works.

In order to live and act rightly in the world, we need to know what we ought to do. A century ago, this question was addressed in many colleges across America in a course for graduating seniors on moral philosophy. The purpose of this course was to convict students that they should apply their knowledge for the pursuit of good instead of pursuing self at others’ expense. At my university, this aspect of college education is expressed in a quotation from Abraham Lincoln carved in stone on a bench behind Lincoln’s statue at the top of Bascom Hill: “Let us have faith that right makes might, and in that faith, dare to do our duty.” The question “What is right?” is represented by the ethics corner of our triad. Moving directly from the Science corner to the praxis corner, or from the ethics corner to the praxis corner, proves problematic, even disastrous. Consider the result of going from knowledge of nuclear fission (science) directly to producing and dropping an atomic bomb (praxis), or moving from the belief that death is bad (ethics) to removing dead wood from forests (praxis); both are examples of these disastrous shortcuts.

But knowing the science and observing the ethics of this stewardship framework does absolutely no good if it is not put into practice—placed into service. By themselves, the very best science and the most substantial ethics are no substitutes for action. We need to act appropriately and deliberately in the light of scientific and ethical knowledge. Praxis by itself, without being grounded in science and ethics, results in mere activism—activism that is unlikely to do good and that may produce harm. All three corners of the triad are essential—but not by themselves. Taken together and working interactively, they provide a framework for stewardship.

But will these three operate in dynamic interaction? Will they interact in ways that preserve and achieve the integrity of human life and the environment? The answer depends on what we know and understand about ourselves and the world (science), what we believe we should do (ethics), and what we in fact do, and how we respond to our successes and failures (praxis). It depends on our will, our motivation, our determination, and our dedication to strive for a harmonious world of creatures before their Creator. What might make us strive for such a world?

Part 3 explores the challenge of translating ideals into concrete actions.

Part of the BioLogos mission, then, is to show how all things hold together in Christ—to show how a Christian worldview integrates the knowledge we have of God through the Scriptures with the knowledge we have of God through the other areas in which he reveals himself as Creator and Redeemer. Our website contains a wealth of Christian scholarship in a wide range of fields—from biology, to cosmology, to mathematics, to Biblical studies, to history, to theology—all demonstrating that the best contemporary science is compatible with Biblical Christian faith. But today we introduce a new tool—the BioLogos Navigator—to make these posts more accessible, and to show how they inter-relate (see sidebar on the right).

Modeled on the astrolabes that early astronomers and sailors used to orient themselves under the heavens, our Navigator makes the cross of Christ the starting point by which we understand the cosmos. Each of the four arms of the cross represents one of the domains of knowledge and experience through which God reveals himself to the world: Scripture, the Church, Nature and Culture. These domains are not in opposition to each other, but are complementary and inter-related areas through which we can recognize God at work in the world. Linking these four domains is a network of specific topics relevant to the science and faith conversation. Their arrangement suggests how each relates to the four domains but also to teach other. Clicking on an individual topic tag highlights not only that topic, but other topics that are linked to it—sometimes in unexpected ways.

Clicking a topic tag a second time takes you to the Topic Landing page: a curated selection of the best resources on that subject from the BioLogos archives. (The image above shows the Christianity & Science—Then and Now Landing page, complete with Navigator and highlighted tags.) At the bottom of each page is a link to our Resource Finder, where you can investigate additional materials on that topic, as well. By exploring the relationships between the topics on the Navigator itself, and by delving deep into each topic via the resources presented on the landing pages, readers can focus on specific aspects of the harmony between science and Christian faith while also getting the wide view of God’s providential work in all things in the heavens and on the earth.

In the coming days and weeks, the BioLogos Navigator will be more fully integrated into the rest of the site, accessible directly from the Forum homepage and from the Resources dropdown list at the top of every page. We’ll also be including features that help place each blog post on the “knowledge map” defined by the domains and topic tags. Finally, the Topic Pages will also be periodically updated with the latest and best new materials in each topic. In the meantime, you can access the Navigator by clicking anywhere on the small image in the sidebar, above, and find a link to this post at the upper right corner of our homepage. So take some time to explore our site with this new tool, which we think will to help orient our readers in the science and faith conversation, while always pointing to Jesus, the Christ, through whom all things were made.

Behe and IC

Since we have previously explored Behe’s idea of irreducible complexity in an entire series, we will not revisit it here in great detail. It is important, however, to reemphasize how Behe defines irreducible complexity (IC). As we noted in the first part of that series, Behe frames his ideas on IC as a counter to Darwin’s ideas of gradualism.

For Behe, the argument for IC is a critique of gradual evolutionary processes, of the kind that Darwin saw as necessary for his theory to hold. When Behe introduces and defines IC in his book Darwin’s Black Box, he has a key quote from Darwin on gradualism explicitly in view:

Darwin knew that his theory of gradual evolution by natural selection carried a heavy burden: "If it could be demonstrated that any complex organ existed which could not possibly have been formed by numerous, successive, slight modifications, my theory would absolutely break down."

It is safe to say the most of the scientific skepticism about Darwinism in the past century has centered on this requirement… critics of Darwin have suspected that his criterion of failure had been met. But how can we be confident? What type of biological system could not be formed by “numerous, successive, slight modifications”?

Well, for starters, a system that is irreducibly complex. By irreducibly complex I mean a single system composed of several well-matched, interacting parts that contribute to the basic function, wherein the removal of any one of the parts causes the system to effectively cease functioning. An irreducibly complex system cannot be produced directly (that is, by continuously improving the initial function, which continues to work by the same mechanism) by slight, successive modifications of a precursor system, because any precursor to an irreducibly complex system that is missing a part is by definition nonfunctional. An irreducibly complex biological system, if there is such a thing, would be a powerful challenge to Darwinian evolution.

(Darwin’s Black Box, p. 39)

The definition of an IC system is thus straightforward: it is a matched group of components, where all the components are necessary for the function of the system. The necessity of each component can be demonstrated by attempting to remove it – if the system no longer works if even one component is removed, it is by definition IC.

Behe and exaptation

The standard response to Behe’s argument from IC is to discuss the evolutionary concept of exaptation: that new systems and functions are cobbled together from components that have functional roles in other systems already present in the cell. Behe discusses, and ultimately dismisses this idea in Darwin’s Black Box as follows:

In Chapter 2 I noted that one couldn’t take specialized parts of other complex systems (such as the spring from a grandfather clock) and use them directly as specialized parts of a second irreducible system (like a mousetrap) unless the parts were first extensively modified. Analogous parts playing roles in other systems cannot relieve the irreducible complexity of a new system; the focus simply shifts from “making” the components to “modifying” them. In either case, there is no new function unless an intelligent agent guides the setup.

So for Behe, two points are clear: parts selected for function in one system cannot be exapted for use in other systems since they would require too many modifications; and the emergence of a new function is the indication that an intelligent agent is guiding the process.

Behe has responded to my previous posts to claim that the tandem duplication event that brought about the Cit+ actualization event should not be considered a gain-of-FCT mutation under his criteria:

The gene duplication which brought an oxygen-tolerant promoter near to the citT gene did not make any new functional element. Rather, it simply duplicated existing features. The two FCTs comprising the oxygen tolerant citrate transporter locus -- the promoter and the gene -- were functional before the duplication and functional after. I had written in my review that one type of mutation that could be categorized as a gain-of-FCT was gene duplication with subsequent sequence modification, to allow the gene to specialize in some task. Venema thinks the mutation observed by Lenski is such an event. He has overlooked the fact that there was no subsequent sequence modification; a segment of DNA simply tandemly duplicated, bringing together two pre-existing FCTs.

As an aside, quibbling over whether this mutation constitutes a “genuine gain-of-FCT” mutation is not my purpose here, since the definition is Behe’s to define, and I am not aware of anyone else in the scientific literature who uses Behe’s definitions. That said, I consider it passing strange to claim that a series of events that produced a gene that has a new sequence and functional properties distinct from either of its component parts does not constitute the production of a new “functional coded element.” If nothing else, it is a functional coded element that has not previously existed, cobbled together from parts of other functional coded elements, displaying new, adaptive properties. If according to Behe’s definition that’s not “new” or a “gain” then I guess it’s not, but that seems to me to torture the words “new” and “gain” beyond recognition. But I digress.

The important point for our purposes, however, lies elsewhere. Note carefully how Behe describes the Cit+ actualization event. By dividing the new aerobic citrate transporter gene into two previously existing FCTs, Behe is describing an exaptation event. The one FCT (the aerobic promoter) starts off as a necessary component of a gene transcribed when oxygen is present. As such it is under selection for that function, which has nothing to do with expressing a citrate transporter. The second FCT (the citrate transporter amino acid coding sequence) is under selection to be a citrate transporter, which has nothing to do with the function of the gene the promoter comes from. The Cit+ actualization event, then, exapts these two FCTs by placing them together to create a new function (which Behe does not mention).

And here’s the kicker: the new system (expression of the citrate transporter when oxygen is present) requires both FCTs in order to work. It has become a system of “well matched, interacting parts that contribute to the basic function” (i.e. transporting citrate in the presence of oxygen) “wherein the removal of any one of the parts causes the system to effectively cease functioning.”

In other words, it is a new IC system – a small and relatively simple system, yes, but nonetheless IC. Now, I’m fairly sure that Behe would not define this system as IC, since the documentation of an IC system evolving would seriously undermine his thesis. I am interested, however, in how he will handle this development, on two fronts. First, he would need to explain specifically why two exapted FCTs that are required together for a basic function does not constitute an IC system (if indeed he wishes to preserve his definition). Secondly, given that he allows for exaptation in this case, he needs to explain how exaptation is not a threat to IC in general. In Darwin’s Black Box he disallows exaptation altogether, but that option is no longer on the table.

In the next post in this series, we’ll continue to explore the evidence for exaptation as a means to build new FCTs, and go on to examine the implications of this evidence for Douglas Axe’s proposed limit to evolutionary mechanisms.

For further reading:

Blount, Z.D., Barrick, J.E., Davidson, C.J. and Lenski, R.E. (2012). Genomic analysis of a key innovation in an experimental Escherichia coli population. Nature 489; 513- 518.

Michael J. Behe, Darwin’s Black Box: The Search for the Limits of Darwinism (New York: Free Press, 2006).

Michael J. Behe, The Edge of Evolution: The Search for the Limits of Darwinism (New York: Free Press, 2007).

Michael J. Behe (2010). Experimental evolution, loss-of-function mutations, and “The first rule of adaptive evolution”. The Quarterly Review of Biology 85(4); 419-445.

The first video, “10 Questions with Katherine Hayhoe”, introduces the scientist in a brief and lighthearted interview. Hayhoe is presented with 10 questions concerning her personal life and beliefs. When asked, she explains that one thing people should know about Christianity is that having a relationship with the God of the universe is one of the most incredible experiences that a person can have. As the video unfolds, the viewer quickly begins to realize that, despite her unique profession of two seemingly incompatible beliefs, Hayhoe is a remarkably sane and “normal” individual. Her role model, she explains, is her father-- the person who first introduced her to science and showed her that it could be “really cool”. On a more serious note, the scientist admits that being both a scientist and a Christian can be difficult. The most frustrating thing about her position, she says, is the amount of disinformation which is targeted at her very own Christian community.

In the second video, “Climate Change Evangelist”, Katharine Hayhoe delves into deeper discussion of the perceived conflict between climate change and Christian faith. She explains that admitting her identity as a Christian scientist can be uncomfortable. Since evangelicals are the targets of much disinformation concerning science in general -- and specifically the science surrounding climate change -- many people in the church have a misguided view of the subject and do not look kindly at her career choice. One woman encountered by Hayhoe at a church in Texas, for example, believed that global warming was a lie taught in schools to mislead her children. In an effort to realign misguided views like these, Katharine Hayhoe and her husband wrote a book addressing the deep-rooted emotions often associated with climate change. People fear that addressing the climate issue will bring forth changes in the economy and uproot their way of life. However, Hayhoe encourages her viewers to act out of love, as the Bible calls us to do, rather than out of fear. Acting out of love inspires us to consider the poor and disadvantaged people around the globe when we respond to the reality of a changing climate.

In the final segment of this three part video montage, Hayhoe addresses the question of what climate change means. Specifically, she is concerned about how global warming affects people on a personal level. While global warming generally brings to mind melting ice caps and polar bears, its implications are far more widespread, affecting the lives of everyone around the world- from cotton farmers in Texas to public health workers in Chicago. If nothing is done to change current emission levels, the number of days per year which exceed 100 degrees Fahrenheit, for example, will begin to increase dramatically, and if emissions are increased, many areas will even develop extreme conditions like those seen currently in Death Valley. Hayhoe’s goal is to demonstrate clearly that the only way to preserve the world for future generations is to significantly reduce dependence on inefficient means of getting energy and instead transition to cleaner renewable energy sources.

Editor's Note: These videos first appeared on the Nova program "The Secret Life of Scientists & Engineers".

There are more things in heaven and earth, Horatio, than are dreamt of in your philosophy.

—Hamlet Act 1, Scene 5

We live in a world driven by the gods of economics, technology and science. Particularly in a time of economic austerity, it is tempting to see the arts or humanities as an optional “extra”—a happy by-product of those true engines of society when they are running smoothly. But in this article we will look at how a biblically informed worldview might turn this perspective on its head, and what the humanities might have to tell us about the present contours of the science and faith conversation.

In his iconic 1959 Rede lecture, “The Two Cultures,” CP Snow noted the dysfunctional relationship between science and the humanities, arguing that the situation is principally the result of our educational system in the West. Ken Arnold, from the medicine and arts focused Wellcome Collection in London, believes that the split continues today, but with the further extension that

In emerging countries . . . amongst the middle classes there is a strong pressure to join the ranks of doctors and scientists and engineers because they see that as the place where future economies are growing. . . . In some ways you could almost begin to feel sorry for the arts and the humanities because they seem to be worth less than the sciences.¹

Is Protestant Christianity also peculiarly prone to such thinking? A skepticism of art in religious spaces as a result of iconoclasm and the reformation, combined with a proud history of the protestant work ethic, economic success, and a profound influence on the history of science, might lead Protestants to be more inclined towards the sciences and technology than to the arts. However, there are more corrosive reasons that science has usurped the humanities in our culture than merely educational or theological bias.

In the early 20th century, logical positivists regarded the humanities as expressions merely of our inner states and desires, but having nothing to do with objective reality. Such imperialistic claims to knowledge denied that other knowledge claims referred to any true reality, and were therefore not really forms of knowledge at all. Bertrand Russell writes,

But if there is a world which is not physical, or not in space-time, it may have a structure which we can never hope to express or to know … Perhaps that is why we know so much physics and so little of anything else.²

Christian scientists are of course very sensitive to this, and work hard to explain that science cannot answer questions of ultimate meaning or the existence of God, which are beyond the scope of science. Often, this line of thinking can be narrow in focus, delineating the limits of the science, and naming those assumptions made by science that cannot be justified empirically. Such arguments can be very fruitful within this narrow context, but we should not be led into thinking that our true perception of reality is limited to such analytic and evidential approaches. There are fields of inquiry that science isn’t able to explain (such as metaphysical judgments, ethics, and beauty), and even our confidence in mathematics— upon which so much of science itself is based—rests upon assumptions that cannot be experimentally demonstrated.

The human condition

Mathematics and the sciences do seem to provide tools by which we are able to perceive the external world and its regularities. However, the arts and humanities, too, are a way of understanding reality, and they tell us less about external reality than the internal human condition. The problem is that the ‘human condition’ seems to have been relegated by many to the realm of mere desire and subjective feeling and, therefore, not reality.

The modernist account of science is that, through our reason, we are somehow able to get outside of nature and describe it objectively. The biblical account, though, has human beings as part of the created order, and so embedded in nature—made from the dust of the earth. Given that, human thought life is also part of the natural world, even despite the fact that it is not best described by the sciences.

The works of Shakespeare, for instance, are part of the created order, as are the poems of Wordsworth, the sculptures of Michaelangelo, and the music of Bach, not to mention children’s nursery rhymes, home decoration, and humming tunes whilst waiting for the bus. As C. S. Lewis wrote, "This is not panache, it is our nature." ³

A little reflection on life reveals something very strange going on here. Somehow, the mythic ‘war’ between science and religion has become the dominant battleground for defending the Christian faith, and competing explanations of the material world are used as apologetic weapons. But the reality is that science plays a peripheral role in our experience of life, not least our life as Christians. Of course that is not to deny the enormous impact of science on the material conditions of our lives, or the prevalence of the products of science. Instead, it is to observe that science plays a facilitatatory role, enabling us to carry out the real core business of our lives, which does not revolve around science. Cars, trains and airplanes are modes of transport to take us to work, or to see family, or go on holiday. Social media provide another way of being in relationship with people. Health services are not an end in themselves, but aim to make people well, so that they can get on with their lives. Why then, when life is not about science, does science dominate our way of thinking about life?

In focusing so much energy on opposing positivism are we not being inadvertently drawn into a positivist way of thinking, that science and material explanations of things are, indeed, our basic reality, what is ultimately true?

A biblical model

“We feel,” wrote the philosopher Ludwig Wittgenstein, “that even when all possible scientific questions have been answered, the problems of life remain completely untouched.” ⁴ Likewise, philosopher Susanne Langer questions any philosophy which claims to be able to explain everything:

Philosophers in every age have attempted to give an account of as much experience as they could. Some have indeed pretended that what they could not explain did not exist; but all the great philosophers have allowed for more than they could explain, and have, therefore, signed beforehand, if not dated, the death-warrant of their philosophies.⁵

Fortunately, the Bible preserves us from total positivist oblivion. There are a great many types of literature represented in the Bible, with the notable exception of scientific writing. If we long to be able to express our deepest emotions, we have the psalms; if we are looking for wise advice, we have the proverbs; if philosophical reflection, Ecclesiastes. There is poetry, song, history, biography, but there is no science. In addition, the Bible refers to the use of the visual arts in, for example, the designs of the tabernacle and temple. The Bible does seem to think the arts and humanities are fundamental for human life, but it doesn’t seem to think that what we think the physical world is constructed of matters much at all.

Do we sometimes read the Bible more like a science textbook than a novel or a poem? Most will agree that each type of literature needs to be read in its own way, but lip-service to that idea notwithstanding, recent arguments prove that it is still possible to read a poem with a scientific mentality—looking out for the ‘facts.’ Is that because we have too high a view of science, or because we have too low a view of the humanities? To say something is poetic is not to declare it ultimately untrue, futile and meaningless—it is to say it is more profound and meaningful and true than many other modes of expression.

According to Langer, part of the problem is the priority that has been accorded to discursive language as the only valid way we have of representing reality to each other. She observes that a study of symbolism shows us that this is actually only one way humans use to abstract from reality, and in fact, the situation even with discursive language isn’t as simple as has been made out. She notes that our sensory organs mediate our perceptions of the world and are already on the job— formulating, framing the world to us—before our cognitive apparatus gets to work. It must be so, or we would not be able to evaluate the importance of the vast array of sensory data we receive and reality would appear as a blur.

A linguistic symbol carries a concept we associate with it, which in turn denotes a reality. In language there is a commonly agreed definition for each word we use, thus enabling communication. But each person also has associations unique to him or her which color any particular concept. Though such personal associations with words are present all at once, they can only be expressed and communicated one at a time, because language is also sequential.

A picture also acts symbolically, though in a different way. Even something as ‘realistic’ as a photograph is likewise a representation of reality and not the reality itself. It also carries with it layers of meaning which reflect the subjective intentions of the person who took the photograph, and opens up for interpretations and associations of the person ‘reading’ the picture. A picture, though, is not sequential. All the information comes at once, and individual blotches of color carry no significance on their own, but only as part of the whole.

No amount of words could ever describe a picture in full. The number of blotches of color and their relations to each other are vast in their complexity, and one could never read words quickly enough to carry the meaning a picture brings in an instant, even if it warrants a far longer period of contemplation. Indeed, though we are only speaking here of visual perception, the same is true of our other sensory inputs, too: they all carry knowledge in quite distinct and profound ways, whilst we, in line with the Greeks, have tended to give sight a special place as the most ‘objective’ of our senses.

As we dig down into empirical science and explore the mechanisms by which sights and sounds and textures are transmitted and processed by the brain, we discover that the meaning of the sense-data which we perceive and which we attempt to describe is likewise profoundly limited by the use of words—much less mathematics—and that our science, as such, represents a tiny fraction of reality.

To suggest, then, that science is the only true way of representing reality—as positivism has done—or to exclude the humanities from our world, leaves us without a proper or even adequate means of expressing the significance we attach to even the most mundane day-to-day activities. Science is very good at describing the regularities of the physical world, but the experience of being human is no less part of the real natural world than are the structure of proteins or the movement of planets, and science does not have the appropriate tools to explore our inner worlds.

Nowadays it seems that Christian cultural life has also too-often failed to fully acknowledge other ways of representing reality than materialist science—ironic because this state of affairs is so at odds with the Bible’s model of using the arts and humanities to profoundly explore the human condition. Perhaps it is time to recover that side of the biblical witness, and remind ourselves that there are more ways of representing the world to each other than positivism has ever dreamt.

Notes

1. BBC Radio 4, “The Life Scientific”, Tuesday 25th September 2012.
2. Bertrand Russell, “Philosophy”, New York. W.W.Norton &Co, 1927, page 265, quoted by Susanne K. Langer, Philosophy in a New Key, Harvard University Press, 1979, page 88.
3. C. S. Lewis, “Learning in War Time” in Fernseed and Elephants and other Essays on Christianity, Fontana, 1975, page 28.
4. Ludwig Wittgenstein, Tractatus Logico-Philosophicus. Routledge and Kegan Paul, 1951, page 187.
5. Susanne K. Langer, Philosophy in a New Key: A Study in the Symbolism of Reason, Rite and Art. Harvard University Press, 1979, p 5.

We tend to think of creativity in terms of flashes of insight and brilliance, of novelty, and especially of unexpected things bursting upon the scene. But creativity is no less creative and no less remarkable when it proceeds step by step, according to discipline, according to rule. We notice significant ruptures in the flow of things and upheavals of the regularity and predictability of life, faith, or science, precisely because such revolutions happen against a background of the ordinary. Even when the rules are interrupted and disturbed, they are usually not obliterated but modified. We and the rest of creation begin again by applying them anew and continuing on in light of what has changed.

Artist Linnéa Spransy makes this paradoxical ‘rules and rupture’ quality of life the method, not just the subject of her art, bringing a fascination with the mathematical underpinnings of the natural world together with her commitment to the kind of renewal-through-brokenness that comes with following Christ. As she says, “the boundaries between art, worship and natural sciences are fluid. I go [to that place of intersection] to be more amazed by the strangeness of existence, to experience awe and wonder.”

Confronted with the scriptural assertion that “eternity is written in [our] hearts,” Spransy wondered how we even begin to understand what that means. What might visual corollaries for such a statement be? How do we represent the tension between freedom and constraint, that dynamic dance of continuity and change, of predictability and surprise, that exists at every level of our experience and study of the world—from quantum physics to genetics to geology—and that seems fundamental to the ways of the Lord with us, as well? Her answer began to form around the study of fractals, mathematical rules whose reiteration in nature leads to endlessly new things. In her own work, a similar fractal sensibility leads to visual representations of something eternal.

Spransy says that every painting she completes “is the manifestation of a predetermined scheme – a system of small limits, with a clear beginning and end. These scripted pieces of visual choreography are allowed to accrue to show me their beauties and surprises, allowing discovery in the midst of certainty.” In other words, images like Frenetic Sequence, 2011, above, are not pictures of natural systems or objects, but representations and results of the processes and relationships by which natural systems and objects come to be. They are built from the inside out, as it were.

To begin a piece, Spransy assembles a library of “research drawings” that play out the various rules and rule sets she intends to use—essentially a kind of preliminary modeling of the visual system she wants to explore. Sometimes these are based on fairly simple mathematical or geometric rules that tell her when a line or shape will turn or divide or end. Other times she uses several different sets of rules at the same time—whether mathematical or derived from biological relationships such as those between base pairs on the DNA strand, or the way bacteria will move towards available sources of food in a Petri dish. But though these rules are established at the outset of a new piece, when she begins a new large-scale work, the outcome is anything but mechanistically predetermined, for several reasons.

First, the physical context in which she’ll be exploring each basic “module” or set of rules is different from that of her research drawings, having moved from a sheet of paper onto large prepared canvases that are five or six feet on a side. She does not transfer the small drawing from the paper to canvas, but regards that earlier work as preparation and practice of the process out of which the final work will emerge. Second, because the works are hand-drawn, there is always the element of her own agency and engagement with both the materials and the rules. There is an inescapably subjective quality to the way she responds to both materials and means. There is also subjectivity to the way she engages with the lines and shapes she has already laid down. Put another way, the abstraction of the rules is always mediated by and expressed through specific, very concrete and physical circumstances.

Finally, Spransy’s process includes what she thinks of as cataclysmic events or moments of chaos: intentional ruptures of the emergent system by gestures that overwhelm and obliterate sections of what she’s already done. Often she will shield sections of the existing system from the coming trauma either by masking them off or by subtly manipulating the flood of color—tilting the canvas to preserve sections of what was there. Afterwards, she will continue scribing and painting lines from the original system on top of or adjacent to the new areas of color, but in ways that respond and adapt to the new visual ecosystem. In this way, layers of work are built up, obliterated, and built up again.

Again, there is an inescapable agency at work in what—from the imagined standpoint of the system itself—must seem a randomly destructive occurrence, but Spransy’s point in breaking into the system is to test the limits of its creative, integrative capacity. By creating “environmental pressure” in this way, then coaxing the fragments and remnant information to multiply and reassert their orderly identities again, she asks, “How flexible are the rules?” The finished paintings are not rote recitations of fractal or statistical formulae, then, but objects with both a physical and a relational history. They are records of a thoughtful, physically engaged, but also humble exploration of how the confluence of order and chaos creates meaning.

Though Spransy denies that there can be such a thing as a “perfect analogy,” her artistic practice has spiritual underpinnings and spiritual implications, as well as visual results. Like many working scientists, she is seeking a way of understanding how the creator engages with His creation, and a better grasp on how we creatures should make our way in response. On one hand, her attentiveness to the basic orderliness of the material creation has a corollary in the familiar disciplines of faith, including reading the scriptures, prayer, and responding with mercy to ruptures in human lives and communities. But on the other hand, her embrace of surprise and chaos is, as she says, an “invitation to the otherness of God,” and a recognition that radically “dissimilar things sometimes occupy the same space.” In combination, those divergent elements help Spransy’s works hover at the boundary between knowing and un-knowing, between control and accident, between freedom and determinism.

Spransy notes that “even in the aftermath of great destruction, life is given great opportunity. In science we’re actually happy and excited when there’s a break in the rules.” This insight, clarified and lived out in her life as well as her artistic practice, directs us to consider not only the necessity and goodness of diligent pursuit of the rules, but also to reconsider the goodness of what we are otherwise inclined to see as calamity and chaos. Indeed, Spransy’s work points us back to the central paradox of the Christian faith: that the most radical disruption of the natural systems of the world occurred two thousand years ago in Palestine with the coming of Christ—singular proof that rupture does not necessarily end in destruction, but may be our means to redemption.

Linnéa Gabriela Spransy grew up in rural Oregon in a community attentive to Christ’s call to live in community with one’s neighbors, but was herself equally aware of God’s presence in the natural world around her. She received her BFA in Drawing from the Milwaukee Institute of Art and Design, and her MFA from the Yale University School of Art. In the midst of exhibiting in solo and group shows in university and commercial galleries, she moved to Milwaukee to study the Bible and consider how it might re-frame her sense of self and her career as an artist. In 2005 she relocated to Kansas City to help found the Boiler Room, a prayer-focused intentional community where she lives and in which she is the artist in residence. She continues to show her work widely, has pieces in pubic and private collections, and was the subject of a recent film-making project: Linnéa: Freedom Through Limits. More of her art can be seen on her website.

Originally posted February 4, 2012

With the complete genome sequence in hand, we knew the sequence and location of our genes, but what we didn’t know was how all those genes are regulated: how do the trillions of cells in our bodies know when to turn on or off all those genes? How do the hundreds of distinct cell types develop and function together, when they are all running on the same DNA “operating system?”

That’s where the ENCODE (short for Encyclopedia of DNA Elements) project comes in. Launched in September 2003, shortly after the announced completion of the Human Genome Project, the goal of the ENCODE project is “to build a comprehensive parts list of functional elements in the human genome, including elements that act at the protein and RNA levels, and regulatory elements that control cells and circumstances in which a gene is active.” In other words, the project seeks to understand how the genome “works.”

Early this month, researchers from ENCODE released more than thirty papers presenting their findings. During a Science magazine online chat, the project’s data coordinator, Ewan Birney, explained the outcome:

The ENCODE project aimed to start our understanding of how the human genome works. We know that (nearly) all the information that determines a human is in the genome, as we all start off as single cell with this DNA. However, we had a patchy understanding of how it works, in particular away from protein coding genes.

To work out how the genome works, we used the fact there are many tiny machines (proteins and RNA - RNA is very like DNA) in each of our cells which know how to "read" parts of the genome. By monitoring where these little molecular machines are on the genome, or how parts of the DNA are copied into RNA (there are quite a few different types of RNA as well), we start to gain some insight into the genome.

We did many such experiments, across different cell types (eg, one cell type was very similar to a liver cell type; another was very similar to a white blood cell). This way not only can we see what is similar, we can also see differences between these cell types.

There is a lot more to get to know and understand here - this is definitely closer to the start than the end. But it is a substantial amount of data, and analysis, to start on this journey.

According to the abstract of one of the lead papers from Nature, this extraordinary glut of data “enabled us to assign biochemical functions for 80% of the genome, in particular outside of the well-studied protein-coding regions.” Only 2% of the genome codes for proteins, but 80% or more has some biochemical function. As a Science news article put it, these 30 papers “sound the death knell for the idea that our DNA is mostly littered with useless bases.”

The pro-Intelligent Design organization The Discovery Institute has heralded the discovery as the “demise of junk DNA.” Casey Luskin writes for their blog Evolution News:

Let's simply observe that it provides a stunning vindication of the prediction of intelligent design that the genome will turn out to have mass functionality for so-called "junk" DNA. ENCODE researchers use words like "surprising" or "unprecedented." They talk about of how "human DNA is a lot more active than we expected." But under an intelligent design paradigm, none of this is surprising. In fact, it is exactly what ID predicted.

The extent to which the ENCODE project been able to identify function has been surprising—even exhilarating—though scientists have for some time been getting glimpses of the many ways in which segments of DNA can be “active.” Even in 1970 biologists knew that some non-coding DNA had function, and by 2003 there was a large body of work demonstrating that many non-coding elements acted as promoters, enhancers, insulators, and so on. Indeed, in recent years many have come to appreciate the fact that “junk” was never really an appropriate metaphor in the first place. Still, because sequencing of multiple genomes has shed such extraordinary light on key evolutionary mechanisms, many geneticists have focused on function primarily in terms of which regions do or do not contribute to the evolutionary fitness of their host, rather than whether they were merely "doing something" biochemically. What the impressive ENCODE project has done is open a treasure trove of new information that can only accelerate the pace at which researchers are able to explore the incredible subtlety and complexity of DNA, and refine the very concept of “functionality.”

So with all this in mind, is ENCODE a stunning victory for ID, as Luskin believes? Bryan College biologist Todd Wood thinks not. He writes, “I don't think that function equates to design, nor do I think that design requires or predicts function. They're not the same thing… my understanding of function does not require me to hypothesize God (or an anonymous designer, if you must) as the proximal cause.”

We agree. Indeed we would go on to say that evolution and design are not mutually exclusive. So while finding function is not sufficient to prove design, recognizing that function has arisen by way of evolution does not indicate that God was not at work. We at BioLogos believe God providentially works out his purposes—his designs—through the elegant processes of evolution, not in opposition to them.

Amazing as the new data are, it only strengthens and enhances our evidence for evolution. While much of the genome is “doing something” biochemically, it is still likely that the majority of the sequence is evolutionarily neutral (Senior Fellow Dennis Venema discusses the evidence for this “neutrality” in a post on our site, including a striking comparison between 29 different mammal genomes and the human genome). In fact, another ENCODE researcher participating in the Science magazine chat, John A. Stamatoyannopoulos of the University of Washington School of Medicine, thinks the findings align beautifully with evolutionary theory:

ENCODE's data provide a unique and powerful window through which to view evolutionary change. We can see those changes directly by lining up the genome sequences of many different organisms -- these line-ups have revealed millions of regions where all the genomes agree, indicating sequences that have been specially preserved by evolution while others have decayed away (ie freely changed their letter codes). We now see that a large proportion of these 'conserved' regions are lighted up by ENCODE annotations, indicating that they are marking spots in the genome that contain important instructions for cell function.

We’ve discussed “junk” DNA previously, including a multi-part series by Dennis Venema, and we’ve received many emails over the past few days asking for our comments on the ENCODE findings. On Monday and Tuesday, Dr. Venema will begin to offer his own thoughts on ENCODE.

A special thanks goes to Darrel Falk, Mark Sprinkle, Kathryn Applegate, Dennis Venema, and Tom Burnett for their contributions to this post.

Photo credit: Jan Bacon

Singer/songwriter Andy Zipf’s “Stumble on the Line” is built around the image of a river flowing through a canyon it has sculpted—an image that can easily be played out as a picture of the way that the Lord has been at work preparing a path for us in the material world, complete with signposts to his former and present activity. Zipf’s imagery of flowing water as a powerful (even dangerous) but also refreshing force echoes the similarly-complicated place of springs and rivers and seas in the scriptures; his description of his own path through the canyon calls to mind the Psalmist’s affirmation that his help comes not from the idols erected on the heights, but from the maker who has crafted both heaven and earth. Here, the river has literally made the canyon, carving it through the “years and layers,” and leaving the evidence of that long work as a sign to all who journey through.

But though Zipf’s canyon provides shelter, a good measure of necessary constraint, and even encouragement to keep moving along the river-course, the thrust of the song is that seeking God is a complicated, sometimes difficult endeavor, whether we are looking for Him through what He has made or through what He has said. The lyrics suggest that walking with the Lord is a path of halting discovery and intrigue, of our learning to notice the way God’s actions in the past are written subtly into the world around us. But Zipf also implies that this is a path that requires obedience, since we are also confronted with the fact that He sometimes speaks to us directly and unequivocally, saying, “follow me.” The song does not take its name and refrain from the river itself, then, but from how we tend to navigate and respond to the terrain it has carved: we “stumble on the line.”

Though pursuing the text’s geologic conceit a bit further is possible, what is more poignant for all of us engaged in the science and faith dialogue is that “Stumble On the Line” is at its heart a love song addressed to the “you” that is the river—the one who has carved the path and along whose banks the singer and we pick our way. Our attentiveness to this terrain of faith does not come first from our desire to analyze and categorize the “evidence” of how it came to look as it does, or even to demystify the mechanism by which a message might be written “in a line of stones.” Rather, what leads us on is the desire to know how to relate to the water itself. The song describes not just a physical path, then, but one of the heart and will.

Indeed, the personal address of the song focuses our attention on the fact that the subtlety or obviousness of the signs along our way have much less to do with whether or not we heed them than does the basic dividedness of our hearts. As Zipf says, we alternate between “trying to reach” and “trying to leave” the One we love. Put another way, we do not reject how God has written his past activity into the layers and years of the earth, or spelled out his intentions for us in the future because they are not obvious, but for the same reason we reject any and all of His claims on us at one time or another: because we wish to be the ones who forge the path, write the story, and sing the song. Our pride—whether in our science or our righteousness—is what keeps us blind and deaf to His leading in our daily path. And yet, even—perhaps especially—in response to our pride, God makes a way for us to gain a better perspective, and leads us on towards Him through whatever means we need.

To return to the language of the song, there is a beautiful ambivalence to the word “stumble,” that contains reminders that following the Lord involves being ever surprised by His ways (we “stumble on” his truth as an unexpected discovery), and ever broken by our own ways (we “stumble on” our pride as an impediment to seeing and following). Yet in both cases, our stumbling leaves us in the same position: on our knees before the one who is both maker and guide. In the last few repeated lines of the piece Zipf affirms that we must and will continue to stumble on in this path of love, whether we come to each stumbling place through surprise and joy, or pride and brokenness. From that position of humility and worship we have the proper perspective to see and affirm that the God who creates is the God who speaks is the God who redeems—the Lord who meets us on our knees, lifts us up, and guides us into the steps of His righteousness.

“Stumble On the Line”

© 2009 by Andy Zipf

I walk a weathered canyon
you're the rapids, running through it
years and layers start to show
in the soil, there is a swelling, beating rhythm to it
earnest prayer I used to know

on the one side, I reach you
on the other, try to leave you
in between the faults of my youth
I stumble on the line to love you

came upon a message,
hidden in some shallow water,
written in a line of stones
telling me to go on down the canyon, follow after. . .
so I keep on. . .

on the one side, I reach you
on the other, try to leave you
in between the faults of my youth
I stumble on the line to love you

I walk a weathered canyon
you're the rapids, running through it
years and layers start to show
in the soil, there is a swelling, beating rhythm to it
earnest prayer I come to know

on the one side, I reach you
on the other, try to leave you
in between the faults of my youth
I stumble on the line to love you.

Though now based in Washington, DC, Andy Zipf began life in the Midwest (Indiana, Illinois, Iowa), but moved to Pennsylania and then New Jersey before his family settled in northern Virginia. He began his career as a professional singer and songwriter shortly after high school, and has performed over 400 times in the last four years—in living rooms, coffee houses, churches, concert halls, and bars. Though “Stumble on the Line” comes from Andy’s 2009 ep “Our Voice Is a Weapon,” his third full-length album and seventh studio release, “Jealous Hands,” became available in July, 2011. More details on Andy and downloads of his music may be found on his website.

While many Christian colleges actively seek to help their students engage issues of faith and science constructively, few secular colleges are active in promoting the conversation. So what is a student to do? They may find it difficult to find a visible role model or mentor that they admire or respect both spiritually and intellectually. Christian faculty at secular colleges and universities often do not feel safe publicly revealing their faith (due to a real or imagined hostile campus climate) or feel ill-equipped to tackle intimidating and controversial topics.

I was fortunate as an undergraduate to find professors in my field that shared my faith. Though we never talked about faith and science topics explicitly, their very presence encouraged me to consider being a Christian professor in chemistry. I grew spiritually in college, largely due to the community I found in InterVarsity Christian Fellowship. My beliefs were challenged on occasion, but I did not really engage issues like evolution. Like Dennis Venema, I was initially attracted to Michael Behe’s Darwin’s Black Box and the Intelligent Design movement. But as I learned more biology as a graduate student and postdoc, I no longer found this position tenable. I was delighted to find Darrel Falk’s Coming to Peace with Science and Ken Miller’s Finding Darwin’s God. They offered perspectives I had not previously heard, and rejected neither the scientific evidence nor the key tenets of the Christian faith. I was fortunate also to hear Francis Collins give several talks on science and faith. Now I knew someone universally acknowledged as an outstanding scientist that was open about his faith, and I agreed wholeheartedly with his approach.

Now, as a professor, how can I encourage my students to authentic engagement and dialogue on issues like this? Following the example of the Veritas Forum, I can call on a common search for truth. But first it requires understanding what is so special about college students.

College students are often living away from home, are exposed to lots of new ideas in a rigorous environment (including, for many, evolutionary biology and philosophy--taught by professors who are assumed to be greater intellectual authorities than any high school teachers), and are seeking direction for their future careers. In short, it is a time of intense exploration and change for many young people. On residential college campuses, students can experience an unparalleled sense of community, engaging in deep conversations in the dining halls and dormitories. More than any other place, colleges and universities are concentrated locations of our world’s future leaders. Charles Malik, Lebanese philosopher, diplomat, and co-author of the Universal Declaration of Human Rights has said, "The university is a clear-cut fulcrum with which to move the world. Change the university and you change the world." Sadly, the message most students in American universities hear today is one of incompatibility between science and faith.

This is not only a concern for Christian students, but for their non-believing peers as well. If agnostic students think it is inconsistent to embrace both science and Christianity, they are very unlikely to be spiritually curious. If science and faith are viewed as mutually exclusive perspectives, it will be hard for students (and even harder for faculty!) to be credible witnesses for the Christian faith on campuses, not to mention being faith-filled scientists. It is because of my love for God, for truth, and for students that I seek to promote harmony between faith and science, Jesus and genes. And sometimes my students’ lives are changed dramatically.

So what practical steps can we take to foster the kind of conversations that need to be had in the university, and what resources are available to help that project along? While there are many available books on the subject, as well as many on-line resources, I am particularly excited about the new From the Dust documentary and the materials BioLogos is providing to accompany them, especially when students can explore then in a supportive group setting. To facilitate exactly that kind of open dialogue, I was invited to develop a study guide to accompany the film, and to try it out in my own college community.

I liked using From the Dust as the centerpiece of the group study plan, as it is visually, theologically and emotionally stimulating. It also takes the Bible seriously and is aimed at starting conversations, rather than ending them with dogmatic answers to challenging questions. I also knew that even though From the Dust is only an hour long, it is packed with potential discussion topics and is probably best viewed over the course of a few sessions instead of all at once. Since I was focused mainly on a Christian audience, I decided to have the students read from Genesis before we started the film, read it again halfway through the film, and read it a third time after we’d finished the film. To deepen the discussion further, and to give students something to think about each week between our sessions, I added six scholarly yet accessible articles that are freely available online from BioLogos, the Faraday Institute, or the American Scientific Affiliation.

My students, several of whom I did not know prior to our science & faith study, were from both Protestant and Catholic backgrounds. Many had not deeply engaged the intersection of science and faith previously, but were dissatisfied with what they had been taught at church or at Christian primary or secondary schools. While individual responses at each session varied, the group was overwhelmingly positive about the content and the process of our study together. Many of the questions we discussed were difficult and emotional, and having the space to wrestle with the ideas together in a supportive group was incredibly helpful.

Tomorrow, I’ll give some more concrete details on how the Study Guide can be used in college and other settings, and also highlight another new film-based resource: The Faraday Institute’s Test of Faith project.

The Denisovans, an extinct hominid group that interbred with modern humans, made the news again lately with the publication of a more detailed study of their genome. One of the many interesting findings was that the Denisovans share the same chromosome 2 fusion that modern humans have. In this post, I review what we know about the origins of human chromosome 2, and then discuss the new Denisovan findings and their implications.

The origins of human chromosome 2: a brief review

Though I have discussed the evidence for a fusion event leading to human chromosome 2 before, perhaps a brief review of the evidence is in order. The human genome is made up of 23 pairs of chromosomes (for a total of 46 chromosomes). This makes us something of an oddity among living great apes, all the rest of whom have 24 pairs of chromosomes (for a total of 48). Given that there are many independent lines of evidence that support the conclusion that we share a common ancestor with other great apes, this poses something of a conundrum: how is it that our species arrived at this specific chromosome number? If we were to represent this “problem” on a phylogeny, or tree of relatedness, it would look something like this (not to scale):

Our closest living relatives, chimpanzees and bonobos, both have 48 chromosomes, as do all other great apes such as gorillas and orangutans. This pattern has one of two explanations, one of which is much more likely than the other. Either the common ancestor to these species had 48 chromosomes, and there was an event that reduced that number to 46 specifically on the lineage leading to humans (option A), or the common ancestor species had 46 chromosomes, and there were independent, repeated events that increased chromosome number in all other great ape species (option B). We can compare these options by placing the required event(s) on the phylogeny (again, not to scale):

It should be obvious that the option that requires the fewest events is the more likely one – in this case option A with an event that reduces chromosome number in the lineage leading to humans. The other option, that of repeated, independent events to increase chromosome number, remains a formal, but unlikely, possibility. Events that reduce chromosome number are not frequent occurrences, so Option A is more likely than Option B.

We can also find further support for Option A, because it predicts a specific type of event, namely one that reduces chromosome number. Since loss of a large amount of chromosomal material is almost always detrimental, we need an event that reduces chromosome number without losing information. One way for this to happen is for two chromosomes to fuse together and become one. Initially, this event would produce an individual with 47 chromosomes, where two different chromosomes get stuck together. Contrary to what is often assumed, this individual would be fertile and able to interbreed with the others in his or her population (who continue to have 48 chromosomes). In a small population, over time, two relatives who both have one copy of the fusion chromosome may mate and produce some progeny with two copies of the fused chromosome, or the first individuals with 46 chromosomes. Since either a 48-pair set or a 46-pair set is preferable for ease of cell division, this population will either eventually get rid of the fusion variant (the most likely outcome), or by chance will switch over completely to the “new” form, with everyone bearing 46 chromosome pairs. While not overly likely, this type of event is not especially rare in mammals, and we have observed this sort of thing happening within recorded human history in other species. Some mammalian species even maintain distinct populations in the wild with differing chromosome numbers due to fusions, and these populations retain the ability to interbreed.

Further evidence for a fusion event in the lineage leading to modern humans comes from comparing synteny, or gene locations and orders on chromosomes within modern great apes – an issue we have discussed here before. In brief, what we see in human chromosome 2 is exactly what we would predict for a fusion event. When compared to other great apes, we see the genes on human chromosome 2 match up, in order, with two smaller ape chromosomes. We also see that sequences used at the tips of chromosomes are present at the proposed fusion site, and that human chromosome 2 has not one but two sites for the cell cytoskeleton to attach to for cell division – but that one of the sites is mutated and not functional, though it lines up precisely with the location of this site on the appropriate ape chromosome. Together, this evidence consistently supports both common ancestry for humans and great apes, and specifically that the difference we see in our chromosome numbers arose due to a single fusion event. I briefly discussed this evidence in my last post where I describe how I teach some of this material and the compelling impact it has on students exploring the evolution question for the first time.

Enter the Denisovans

With that as background, we are now prepared to appreciate a new finding that comes from genomics work done on the Denisovan hominids, an archaic species that is more closely related to Neanderthals than to us, but that nonetheless interbred with some anatomically modern humans as they migrated out of Africa and populated the globe. (For those not familiar with the Denisovans, or the evidence for our interbreeding with them, both Darrel Falk and I have written on this previously, here and here). Recently, a more detailed understanding of the Denisovan genome was published, and nested in the new information is the discovery that the Denisovans share the 46 chromosome set with the same fusion that we have. This strongly supports the hypothesis that the fusion event predates the separation of our species. If we were to represent this on a phylogeny, we can now place this event with more accuracy than before (as before, the phylogeny is not to scale):

Despite this new information, one obvious question remains. Did the Neanderthals also have the 46-pair set? From looking at the phylogeny above, we can see that the most likely answer is that they did, since the fact that the Denisovans had it strongly implies that the last common ancestor of humans and Neanderthals / Denisovans had it as well, and the Neanderthal-Denisovan split comes later. While the Denisovan DNA samples are of high enough quality to make this assessment, we do not yet have Neanderthal DNA of high enough quality to do the same analysis with current methods (though one additional feature of the new work on the Denisovan genome is developing more sensitive DNA sequencing techniques that may resolve this question in the future).

In other words, this fusion seems to be an ancient one, predating our species by several hundred thousand years. Present estimates of the last common ancestor between humans and Neanderthals / Denisovans range at about 800,000 years ago.

Implications for understanding our “becoming human”

The main implication from this work is that it places the fusion event well before the advent of our species. I’ve often chatted informally with Christians about evolution, and at times some have thought that this fusion event was what “started” our species, or made our species unable to interbreed with other groups. Some have even suggested that perhaps the fusion event was what produced the first human (i.e. Adam).

Note that thinking this way suggests a misunderstanding of how chromosome fusions occur and what effect they have on their hosts. A fusion does not precipitate a speciation event, but rather the individual with the fusion remains a part of his or her population, and able to interbreed, even if with reduced fertility. Also, there is no necessary biological effect or change that the fusion produces on the appearance of the organism. These misunderstandings aside, however,what this new evidence shows is that this fusion event took place long before modern humans arose at around 200,000 years ago. Indeed, the 800,000 years ago date for the last human - Denisovan common ancestor means that this is the most recent date possible for the fusion. While it is an interesting piece of our evolutionary history, it doesn’t seem to have much to do with how we came to acquire the traits that set us apart from, and ultimately outcompete, other similar species.