So, I’ve decided to try a slightly different approach for the next while—one that has these sorts of folks in mind. From time to time, you can still expect those more in-depth, technical articles, or perhaps a discussion of some new research that makes the popular press, or even an analysis of some new argument from the IDM or RTB. These will be breaks from the new routine, however. For the most part, we’re going to stick to the basics, much like you would if you took an introductory evolution course at a university. Don’t worry, though: this course doesn’t have any prerequisites! All that’s needed is a willingness to learn.

What you can expect

The goal of this course is straightforward: to provide evangelical Christians with a step-by-step introduction to the science of evolutionary biology.  This will provide benefits beyond just the joy of learning more about God’s wonderful creation. An understanding of the basic science of evolution is of great benefit for reflecting on its theological implications, since this reflection can then be done from a scientifically-informed perspective. From time to time we might comment briefly on some issues of theological interest (and suggest resources for those looking to explore those issues further), but for the most part, we’re going to focus on the science. For folks interested in the interaction between science and Christianity, I heartily recommend Ted Davis’ recent series as a fabulous introduction to the topic.

You can also expect a slow, patient pace. Since this course is intended for folks with little or no background in biology, we’re going to take our time to make sure no one gets left behind. This might be frustrating to folks who already know a fair bit about evolution. Hopefully even more knowledgeable readers will learn some new and interesting details along the way—but the goal will primarily be to help folks who are less well versed in evolution increase their understanding.

You can also expect a survey of many different areas that have some bearing on evolution. We’ll examine geology, paleontology, biogeography, genetics, and a host of other topics in order to provide a “big picture” overview. This broad-brush approach means that any given individual post will not necessarily be “convincing” to folks who have doubts about evolution. Think about assembling a large jigsaw puzzle: placing any individual piece, on its own, doesn’t convincingly demonstrate what the overall picture will show. This course will be like that. Each topic we cover will put a few pieces in place here and there, slowly building towards the final overall picture.

Since evolution is an active science, this process will also highlight where there are “missing pieces” that are still being sought by scientists. All of this is well and good, since the purpose of this course is not so much to convince anyone of the validity of evolutionary theory, but rather to inform readers about the nature and scope of evolution as a scientific theory in the present day. My goal is to provide readers with a basic understanding of what evolution is and how it works. Given that as the primary goal, if one finds the scope of the evidence ultimately convincing (or not) is somewhat beside the point. The intent here is to provide readers with information they can use to make their own, informed decision.

How you can help

First and foremost, you can help by spreading the word about this series to folks you think would be interested in learning more about evolution in a non-threatening environment. Secondly, you can help me by asking questions in the comments. One of the challenges of being a specialist is having the ability to put oneself in the shoes of someone just starting out. What might seem obvious to me may not seem obvious to you, and I hope you’ll feel that no question is too basic or too simplistic. If you’re wondering about something, it’s almost guaranteed that other folks are, too! So, please don’t be shy. I’ll do my best to answer questions in the comments, though I hope that some of our more skilled commenters will (respectfully!) help out here, as well. Finally, you can help by letting me know what broader areas of evolution you find confusing. I have my own ideas about what areas of evolution are commonly misunderstood, but I’d love to hear from readers about what areas they find difficult to understand. I’ll use this input to shape the topics I will cover as we go forward.

Getting started

In the next post in this course, we’ll dive into the course content by introducing two key areas: how scientific theories work in general, and how evolution in particular works as the current organizing theory of modern biology. 

Evidence from the Size of the Universe

We’ve already discussed the vastness of the universe earlier in this chapter. We noted that the most distant galaxies are over 10 billion light years away, indicating that the light left these galaxies over 10 billion years ago in order to reach us today. The straightforward interpretation of these data is that the universe must be at least 10 billion years old.

While some people have argued that perhaps these galaxies aren’t really that far away, all of the methods used to measure distance agree that galaxies are billions, not thousands, of light years away. Others have argued that perhaps the light moved much faster when it first left these galaxies, so that it could reach us in much less time than 10 billion years. But this idea conflicts with other data that we have. As described in Chapter 3, ample evidence supports the idea that physical processes such as quantum mechanics and electromagnetism function the same way in distant galaxies as they do on earth. Those physical processes depend on the speed of light and would look very different if the speed of light had changed. Instead, they look the same in distant galaxies as they do on earth, indicating that the speed of light has been constant over the history of the universe.

Evidence from the Moon and Planets

Studies of the Moon and planets also give evidence for great age. Geologists can use some of the same methods to measure the age of rocks on the Moon, Venus, and Mars as they use on Earth. That’s because the asteroid collisions, volcanoes, and erosion they observe on Earth also occur on the Moon and planets. Photos taken by spacecraft while orbiting Mars show channels and gullies on the planet’s surface. Similar channels on Earth are usually made by flowing water. Yet there is no liquid water on the surface of Mars right now.

What does this have to do with age? It is evidence that Mars was much different in the past than it is today. The atmosphere used to be much thicker and warmer, similar to Earth’s, but now it is much colder and thinner. This dramatic change in planet-wide climate took millions or billions of years. Thus the rocks testify that the planet Mars must be at least this old.

Evidence from the Orbits of Asteroids

The orbits of asteroids also show evidence of a long history. When an asteroid is discovered, its path through the sky shows its orbit around the Sun. Once astronomers know the orbit of an asteroid they can calculate its orbit in the past and into the future to see whether it will hit the earth. By calculating the orbits backward, astronomers have found several asteroids that converged at the same location several million years ago. Apparently two larger asteroids collided at this spot and shattered into the smaller asteroids we see today. If God had created asteroids just a few thousand years ago, why would he have put them in orbits that suggest a collision several million years ago? The evidence clearly points to a long history for asteroids.

Evidence from Meteorites

Radiometric dating is used to study rocks on Earth as well as rocks from elsewhere in the solar system. Studies have been done on the rocks that astronauts brought back from the Moon and on asteroids that have fallen to Earth. As with Earth rocks, scientists use multiple radioactive isotopes to cross-check age measurements. At least three different isotopes have been used to measure the age of Moon rocks, and at least five different radioactive isotopes have been used to measure the age of meteorites. The results all agree: the oldest Moon rocks and asteroids are 4.6 billion years old. This is our best measure of the age of the solar system as a whole. The universe itself must be at least this old.

Evidence from Star Clusters

Another important measure of age in the universe comes from star clusters. Because all stars in a star cluster form in the same nebula at about the same time, they all have about the same “birthday.” But they don’t all have the same lifespan. High-mass stars burn bright and fast like a “flash in the pan,” while low-mass stars burn slowly and steadily. Consider how this will look in a star cluster. A cluster starts with many stars with the same birthday but of all different masses. Over time the high-mass stars die off first, leaving behind the low-mass stars. This means that if many high-mass stars are present, the cluster must be young because they haven’t burned out yet. If most of the stars are low-mass, the cluster must be old. Careful studies of star clusters show that some clusters are younger and some are older, with the oldest ones having an age of about 12 billion years.

Multiple Lines of Evidence

The most distant galaxies, the planets and asteroids of our own solar system, and the oldest star clusters all are several billion years old. Astronomers have many different methods for measuring the age of various objects, and they all support ages of billions of years, not thousands. Even if the assumptions of one or two methods were faulty, it is highly unlikely that all of the methods would be affected. Like the geologists in the 1700s, astronomers today have found multiple lines of evidence against a young earth and young universe.

It may seem as though we are once again describing a conflict between science and theology. Scientific results that indicate great age do conflict with the Young-Earth Interpretation of Genesis 1 discussed in chapter 5. But remember that in chapters 5 and 6 we presented many other interpretations of Genesis 1; several of these are not in conflict with the great age found in the book of nature. In chapter 6 we also explained why we believe that the best biblical scholarship, quite independent of modern science, indicates that Genesis 1 was never meant to convey scientific information to the original audience. Its intent for the first listeners, and for us, is to teach the who and why of creation, not the how and when. Taken in this context, there is no conflict between Genesis 1 and the astronomical evidence for great age.

For background on related topics (like the reliability of historical science and interpretations of Genesis), see previous excerpts from this series.

Excerpt from Chapter 7 of Origins: Christian Perspectives on Creation, Evolution, and Intelligent Design (Grand Rapids, MI: Faith Alive Christian Resources), 2011. Reprinted with permission. To purchase a copy of the book or e-book, call 1-800-333-8300 or visit www.faithaliveresources.org.

Want a free copy of Origins?  For a limited time, donations of $50 or more will receive a  copy of the book! Plus, from now through April, your gift will be doubled thanks to a matching grant from a generous donor. You can learn more here.

Such remnants are also found in our genomes.  Humans, unlike most mammals, cannot synthesize (make) our own vitamin C, but we carry the genes for synthesizing vitamin C.  One of these genes encodes the GLO (L-gulonolactone oxidase) enzyme, and this gene in humans contains inactivating mutations and is therefore a “pseudogene.”  This pseudogene and the genes that encode the enzymes of the vitamin C biosynthetic pathway are the remnants of our own evolutionary lineage from an ancestor that was able to synthesize its own vitamin C.⁴ Furthermore, the GLO pseudogene is just one of a graveyard of inactivated genes, transposons, retroviruses and other non-functional sequences that litter our genome.  While some of these sequences have been co-opted for particular functions, many of them have no known function.⁵ We share many of these non-functional sequences with chimpanzees.  The very presence of these genomic and anatomical flotsam and jetsam only makes sense if evolution has occurred.⁶

A third piece of evidence for evolution comes from biogeography.⁷ The flora and fauna of islands such as those of the Galápagos and Hawaii are radically unbalanced in that they lack many types of plants and animals but contain a profusion of clusters of similar species.  Hawaii, for example, has no native mammals, reptiles, or amphibians, but a profusion of fruit flies and silversword plants.⁸ One third of the 2,000 species of fruit flies are found on the Hawaiian Islands, which only covers 2 percent of the land on earth.  These islands were never connected to the continents and arose as a result of volcanic activity and were, at least initially, completely uncolonized.  The colonization of these islands occurred by means of occasional introduction of creatures from the mainland that then rapidly speciated on these islands to fill every available ecological niche.  Thus, the organisms most closely related to island species come from the closest mainland areas, and often include those creatures most likely to find their way to islands, such as birds and flying insects. 

The Galápagos Islands provide an excellent example of how biogeography provides evidence for evolution. The Galápagos have fourteen species of finch whose closest relative is probably the South American grassquit (Tiaris), yet only four of these finch species feed on seeds as finches normally do, while two others feed on cacti, seven eat insects, and another eats almost exclusively leaves.⁹ Darwin, while visiting the Galápagos, still thought that species only varied within a particular kind (though he would not have used that terminology) but could adapt to various local environments and become particular subspecies. Therefore, he originally listed the warbler finch (Certhidea olivacea) as a wren and listed the small cactus finch (Geospiza scandens) as a member of the Icteridae or the family of meadowlarks and orioles.  Only after Darwin had deposited his Galápagos specimens with the British ornithologist John Gould did Darwin discover (in a meeting with Gould that occurred during March, 1877), that his finch collection included thirteen or fourteen species of unusual finches that were all so closely related, Gould classified them in a single group all their own.  This meeting showed Darwin that the immutable barrier between kinds of species did not exist.  The Galápagos Islands were not a distinct “center of creation,” but a workshop for evolution in which an ancestral species made it to the yet uncolonized island and underwent a massive degree of speciation to adapt to the environment of the island.¹⁰ This is precisely what one would expect if the species of islands had arisen by evolution. 

A scientific theory also allows scientists to make predictions, and good theories provide accurate predictions.  Can the theory of evolution allow accurate predictions?  The answer, once again, is yes.  Darwin himself predicted that the earth must be very old for evolution to occur.  He did not know the age of the earth, but further research has shown that the earth is 4.55 billion years old, which is plenty of time for evolution to occur.  Darwin also predicted that since plants on islands were most closely related to certain mainland plant species, the seeds of these plants should be able to withstand immersion in sea water for long periods of time, and again, Darwin was shown to be right.¹¹ Many decades after Darwin, we now know that variation in organisms is due to mutations in DNA and that these mutations are inherited, just as Darwin predicted.¹² Also, Darwin’s principle of natural selection predicts that particular sequences of DNA should behave in a manner that benefits only themselves and not their carriers, which modern research has thoroughly confirmed with the discovery of transposons and other types of “selfish DNA.”¹³

Is evolutionary theory a good scientific theory?  It has been repeatedly tested for over 150 years since its inception, and it has passed those tests successfully.  The theory has been modified in response to new data, but the outlines of the theory have remained largely intact.  It has existed at risk from new data.  During the molecular biology revolution that began with the discovery of the structure of DNA by Franklin, Watson and Crick in 1953, the explosion of new data could have shown contemporary evolutionary theory to be wrong.  However, some of the most powerful evidence for the theory of evolution has come from a field of science that did not even exist during Darwin’s time.  The ability of a theory to withstand such intense scrutiny is a clear sign it is robust and enduring.  As shown, the theory of evolution has predictive power, and it also integrates and makes sense of data from several fields of science, including ecology, paleontology, genetics, historical geology, paleoclimatology, and comparative anatomy and biochemistry.  The highly integrative nature of evolutionary theory makes it a fine theory by any measure. 

In conclusion, when measured against the standards of a good scientific theory, modern evolutionary biology clearly qualifies as good science.  Ongoing debates within evolutionary biology exist about mechanism, rates, and causes, but not over whether evolution occurred.  Such a question has been largely settled by the last 150 years’ worth of research.  The future certainly looks bright for this field of science and I cannot imagine a more exciting topic to study. 

Notes

1. Davit-Béal, Tiphaine,Abigail S. Tucker, and Jean-Yves Sire. “Loss of Teeth and Enamel in Tetrapods: Fossil Record, Genetic Data and Morphological Adaptations.” Journal of Anatomy 214, no. 4 (2009): 477–501. 

2. Tian, Natasha M. M.-L., and David J. Price. “Why Cavefish are Blind.” BioEssays 27 (2005): 235–38; Yamamoto Y, Stock DW, and Jeffery WR (2004) Hedgehog Signalling Controls Eye Degeneration in Blind Cavefish. Nature 431:844–7; Jeffery, W. R. “Adaptive Evolution of Eye Degeneration in the Mexican Blind Cavefish.” Journal of Heredity 96, no. 3 (2005): 185–196. 

3. Bejder, L., and B. K. Hall. “Limbs in Whales and Limblessness in Other Vertebrates: Mechanisms of Evolutionary and Developmental Transformation and Loss.” Evolution and Development 4, no. 6 (2002): 445–58. 

4. Lachapelle, M. Y., and G. Drouin. “Inactivation Dates of the Human and Guinea Pig Vitamin C Genes.” Genetica 139, no. 2 (2011): 199–207.

5. Avise, John C. Inside the Human Genome: A Case for Non-Intelligent Design. New York: Oxford University Press, 2010.   Romano, C. M., F. L. Melo, M. A. Corsini, E. C. Homes, and P. M. Zanotto.  “Demographic Histories of ERV-K in Humans, Chimpanzees and Rhesus Monkeys.” PLoS One 2, no. 10 (2007): e1026. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001026. 

6. Max, “Plagiarized Errors and Molecular Genetics,” http://www.talkorigins.org/faqs/molgen.

7. Coyne, Jerry A. “Intelligent Design: The Faith that Dare Not Peak Its Name.” In Intelligent Thought: Science Versus the Intelligent Design Movement, edited by John Brockman, 3–23. New York: Vintage, 2006. 

8. Kricher, John. Galápagos: A Natural History. Princeton, NJ:  Princeton University Press, 2006. 

9. Grant, Peter R., and Rosemary B. Grant. How and Why Species Multiply: The Radiation of Darwin’s Finches. Princeton, NJ: Princeton University Press, 2011. 

10. Sulloway, Frank J. “Why Darwin Rejected Intelligent Design.” In Intelligent Thought: Science Versus the Intelligent Design Movement, edited by John Brockman, 107–25. New York: Vintage, 2006. 

11. Darwin, Charles. “On the action of sea-water on the germination of seeds.” Journal of Proceedings of the Linnean Society of London (Botany). 1 (1857): 130–140.

12. Futuyma, Douglas J. Evolution. 3rd ed. Sundbury, MA: Sinauer Associates, 2013. 

13. Dawkins, Richard. The Selfish Gene. New York: Oxford University Press, 2006.

JIMMY LIN: Currently I’m on faculty at Washington University at St. Louis, where I am a research instructor in the pathology department. Also, a year and a half ago, I founded the Rare Genomics Institute (RGI)—a nonprofit that helps find cures for people with rare diseases.

ER: What qualifies as a “rare disease”?

JL: These are diseases like cystic fibrosis and Huntingdon’s disease—diseases that affect less than 200,000 Americans each year. There are over 7000 different rare diseases, and less than 5% of them have any therapy. Altogether, they affect about 25-30 million people.

This creates what we call a “long tail problem”—it’s hard for a top-down research system to create research programs for all 7000 rare diseases. So instead, we are creating a bottom-up platform from which the patients themselves can create research projects and help fund them. We connect patients with physicians and researchers, customize a research program with top medical universities, design the experiment, and then use an online fundraising platform to fund the study through [mostly] friends and family of the patient.

Basically, we create a “foundation in a box.” By partnering with the Rare Genomics Institute, patients and their friends and families who want to study rare diseases don’t have to go through the hoops of creating their own nonprofit or lab—we do that for them. So, instead of creating 7000 different nonprofits, we create a generalized platform from which studies can be conducted.

ER: Who qualifies for care through the Rare Genomics Institute?

JL: Anyone with a rare disease can come to us. The main thing we’re doing right now is diagnosis. When families come to us, they either don’t know the disease that’s affecting them or their child, or they don’t know the gene that’s wrong.

For instance, if a child had a condition that doctors couldn’t identify, his or her parents might come to us for help. What we’d do then is sequence the genes of the mother, father, and child, and compare them to reference genome to determine what mutations each of the parents have. Depending on what the disease is and what the gene causing it is, we can filter out mutations that don’t mean anything using the parents’ genomes—then, after filtering, we can potentially pinpoint the genes that fit the genetic pattern of the disease. This is the first step.

After that, we are building infrastructure to determine the effect of these changes and a way to help. For example, after looking at the literature, we can perhaps design experiments using cells extracted from the patient; this part of the process is different for every disease. Then, if we can determine that there is, for instance, a pathway missing a specific enzyme, we can try using drugs, a bone marrow transplant, or gene therapy to try to put healthy cells into the child… But there’s a variety of diseases, of course, so there’s a variety of different approaches—and we’re just starting to explore these aspects.

ER: How did RGI get started?

JL: It really started when I was in medical school at Johns Hopkins—there was this boy that came to our clinic to be seen. My research was in cancer genome sequencing, and the family had come to our department looking for answers about what was wrong with their son. At that point, the family was almost hopeless—they had gone to so many doctors, run so many tests—I decided I wanted to try to help children like this. That’s when my friends and I decided to start the Rare Genomics Institute.

Currently, there are about 50 researchers associated with the organization, and we are all volunteers. It’s growing much, much faster and been more amazing than we’ve ever imagined—we’re already making an impact. In May of last year, we were able to discover a new disease using the world’s first crowd-sourced, crowd-funded genome. Working with researchers at Yale, we delineated a disease of which our patient was the first identified.

Right now, we’re in the middle of raising funding and hiring staff to make this organization one that is self-sustaining, and to increase its impact even more.

Excerpts from Michael Hickerson Interview

MH: …you call yourself a doxologist. What’s the full term you used in your Jubilee bio?

JL: Medical and scientific doxologist.

MH: How did you decide on that term and what does it mean to you?

JL: I listen to a bunch of teaching by J.I. Packer , who teaches theology at Regent College and is one of the leading thinkers on these things. Interestingly, before any one of his classes, he says “Theology is for doxology,” and then the whole class sings the Doxology together out loud in class. I thought, “Wow, that is so great,” because everybody sometimes learns theology just for intellectual things [instead of for worship].

That’s not just true for theology, it’s for everything: biology is for doxology; chemistry is for doxology. That’s when I started to think, I should consider myself, first and foremost, as a person who praises God in what I do. And then no longer make “Christian” the adjective, right? “Doxologist” is the noun. But then what kind of doxologist am I? So I call myself a medical and scientist doxologist. I would call someone, for example, in the marketplace, a business doxologist. Or, someone who does art, an artistic doxologist. To really have the noun as our identity, and then our vocation as just a descriptor of how we do that.

MH: That’s a great point. A noun is always stronger than the adjective. So, you want that to be the focus, rather than the add-on.

JL: In our current culture, we’re defined by our jobs. It’s having a vocation. I wanted to shift away from that. I didn’t want to be a doctor first and foremost, or a scientist, but one who praises God. And evidently, within science you don’t want to call yourself a Christian Scientist. That’s another religion, so . . .

MH: [laughs] That’s right. I run into that, as well, when I’m teaching or talking about science to Christians. You always run into that stumbling block.

JL: With “scientific doxologist,” people don’t confuse them. You do have to explain what it means. And that gets in a little story actually, on what it means about vocation. It’s a small lesson — a teaching point when you do talk to people about vocation and calling. That’s why I use it.

MH: I guess my final question would be what spiritual practices help sustain you? What helps you stay in contact with God and keep a good foundation?

JL: First, I am interested in many, many different things. I sort of mix it up in terms of spiritual practices. Besides the fundamentals, of course, of quiet time, devotional reading, and scriptural reading, I do theological study because I have to do that academically. I find a lot of time with God through the spiritual disciplines, such as times of solitude — which is very interesting for someone who is in academics to no longer think about ideas but just to be quiet before God — how silence, time to think by yourself, or sitting in silence is also something you should foster.

In terms of spiritual formation, what you really need is definitely a good community of people. I have a very supportive community at my church. I’m the deacon of devotions, so that of course keeps me on track. It encourages me as I, in my own spiritual walk, encourage other people. Fundamentally, I think for all Christians, whether you are academic or no matter your vocation or calling, being in the Word and prayer are the most important things. Doing that and being spiritually fed is what is important.

DOUG LAUFFENBURGER: It could look like a lot of things. One way to envision what I mean is to put yourself back a hundred years. For instance, in 1913, an electronic computer was unimaginable. But using physics, quantum physics, leading to semiconductors and devices like that, people figured out over the next 20 to 30 years how you could build a machine to do calculations and so forth. And then, of course, all sorts of thing happened…

We’re roughly at that stage with biology, even though it seems like things are more imaginable because—and we don’t have to go strictly century by century here—because we can already guess the way some things might change, whereas in 1913 there was no inkling, really, as to what would happen in the computer revolution.

So, to enumerate some of the things that are conceivable—let’s just start with computers, because we were just there.

There’s a notion that computers get faster and cheaper by making their logic gates smaller, and how you improve a design with physics keeps bumping up against how you make these little units smaller. Well, using biology, the solution seems self-evident—you just line up the pieces of DNA, and if you put the right pieces of DNA in the right places, the resulting parts are so much smaller than the things we can do with physics. You can imagine, even though it’s just a theory now, computers continuing to become many times smaller and cheaper—and be made via environmentally benign manufacturing processes—through biomolecular construction.

Now that’s exciting from one point of view, but from another, it’s not that revolutionary, because you’re just using DNA as a piece of physics. It’s not really biology—it’s merely a biological molecule being used to make better physics.

For a different example, if you think about the way we make things, the way we manufacture plastics, gasoline, energy—we have to do all that using chemistry, and to make that chemistry happen, we have to input a lot of energy—in fact, one of the most costly industries in terms of energy usage is the energy industry. You have to put in so much energy to refine petroleum and things like that. And to make plastics, ceramics—things of that nature—is also very energy intensive, and it’s also where a lot of pollution comes from, because you’re mixing together all these chemicals that really didn’t want to be mixed together. You get what you want, but you get a lot of byproducts, toxins, etc.

Well, people have started to realize that a lot of this work can be redone through the use of biology. You can turn corn into fuel or plastic, and you can make magnetic or electrical storage devices out of biological units (viruses can pattern the crystals, so instead of using mixtures of toxic chemicals, you just pull the viruses with the right properties together). Right on this tabletop, you could make materials that by current manufacturing processes would otherwise cause a great amount of environmental hazard.

As for another exciting development—well, to preface, one of the problematic things about modern agriculture is the necessity of using fertilizers (there are insecticides to be concerned about, too), but fertilizer manufacturing is terrible for the environment. You have to make fertilizer out of ammonia and that’s a horribly polluting and energy-intensive manufacturing process. What you could potentially do, instead, is program into bacteria the genes that take nitrogen out of air, turning it into organic nitrogen then just scatter the bacteria onto the field—and you wouldn’t need to make ammonium using the current very caustic processes.

These are the sorts of things I mean—and we haven’t even touched on medicine, yet. People tend to think about medicinal advances, first, but before you even get to medicine, you can think about energy, manufacturing, materials, and agriculture. In 50 years, we should be able to do things in ways we don’t do them now, that will be cheaper, less toxic, less polluting, more efficient, and so forth.

ER: A lot of people are nervous about the idea of “programming” life. Can you respond to this fear as a Christian?

DL: As a Christian, I would say that God gave humankind dominion over the earth, to do good things—he gave us minds, a passion for understanding how things work, and then he put in this world all these fascinating processes, which, if we figured them out, we could do good things, could feed more people—could feed more people without causing extensive damage to the environment. And cure disease and injury. And the list goes on. I think all that is good, and that God would be pleased that we would be using His creation to live better—I’m not saying more luxuriously, but more happily, contentedly, with each other.

ER: But back to the topic—advances using biology in the next century. You had just mentioned medicine…

DL: So, yes, there’s also medicine. Now, obviously, in thinking about this, the use of stem cells comes to immediately the fore. There are a lot of diseases out there that you really do need to correct using cellular processes. Right now, we try to make these corrections through chemistry. For instance, we give you a pill, and that pill should interfere with something that’s going wrong in your body—and yet it’s really never adequate to just interfere with something that goes wrong in the body, because you don’t really set it right just by getting in the way of it.

The opportunity with stem cells is that you can say, “I’ll replace the cells in the body that are doing something wrong with cells that are actually doing it right again.” If you program cells to be neurons, heart cells, or bone cells, you can regenerate properly functioning physiology. Rather than, say, replacing a hip with a metal part, you could regenerate the bone, itself, or you could regenerate neurons in Alzheimer’s patients. Never in the past has medicine been able to regenerate a proper physiology; it’s only tried to replace it with an inadequate surrogate, or minimize how much damage a disease is doing. With the use of stem cells, you can actually imagine returning the body to its proper physiology.

A different use of stem cells is to generate human tissue in the laboratory for better studies of human physiology and pathology and improved testing of drug effectiveness and toxicity.  This will be a major advance over animal models, because of the significant disparities between animal physiology and human physiology.

A key point to emphasize is that there are different kinds of stem cells, which involve big differences in potential concerns. For Christians, clearly, stem cells derived from embryos present a tremendous ethical issue. Fortunately, a good proportion of stem cell technologies can be pursued using stem cells from adult tissue. These cells can be stimulated to develop into certain tissue-specific physiological behavior, or can now even be “re-programmed” to become quite similar to the more broadly flexible stem cells derived from embryos but now not requiring the embryonic source. Happily, the days of reliance on embryo-derived stem cells appear to be over for purposes of beneficial technologies.

We also should consider genomic medicine, and what’s attractive about that field is that with the way we do medicine now, which is chemistry-based—say you have a disease, and we might give you a pill to correct it—well, the biggest problem with that is that while I think this pill will help ameliorate your condition, maybe it won’t. Maybe that drug only works in ten percent of the patients and not ninety percent.

For example, consider cancer. You’ve got a particular kind of cancer, and we prescribe a certain treatment… well, hopefully you’re among the lucky ten percent, and you’ll be in much better shape in two or three years. If you’re not, then we’ve wasted your time. In fact, we’ve probably hurt you rather than helped you, because we’re using chemistry to interfere with things, and even though we might be reducing the damage of some things, we’re probably causing toxicity elsewhere in the system, because that same chemistry is also interfering over there.

So the value of genomic medicine is to get enough information about you through sequencing your genome that we can say, “Ah, for you this particular pill is not a good idea; it will actually do more damage than good. But for your brother, it’s likely to work, and the ratio of benefit to harm is much better.” This is the reason genomic medicine is more imminent—it’s what’s closest on the horizon to being realized—because we can use the same drugs we have now, we’ll just be using them more effectively. At the moment, we can sequence genomes, and we do have these treatments that help, and it’s just a matter of matching up these two technologies.

Now, on the other hand, when you think about genome sequencing, you can find out all sorts of things, and you have to decide, “What if I learn something negative?”

EDITOR’S NOTE: Join us next week as we continue the conversation about genomic medicine, bioengineering, and being a Christian in science.

Belief in God in an Age of Science

Introducing John Polkinghorne

An Englishman of Cornish descent, John Polkinghorne was born in 1930 in the coastal town of Weston-super-Mare, southwest of Bristol in North Somerset. Although his parents had three children, an older sister died in infancy and his older brother, who served in the RAF Coastal Command during World War II, died when his plane was lost over the North Atlantic on a stormy night in 1942. Effectively an only child from that point on, his family nurtured him in their Christian faith, leading him to say a few years ago, “I cannot recall a time when I was not in some real way a member of the worshipping and believing community of the Church.”  (From Physicist to Priest, p. 7)

At the same time, his gift for mathematics did not go unnoticed, resulting in several years of study at Trinity College, Cambridge (where Isaac Newton had lived and worked in the seventeenth century). As an undergraduate, Polkinghorne studied applied math rather than pure math, a typical choice for someone interested in physics. There, he formed a close friendship with a classmate, Michael Atiyah, who would be best man at his marriage in 1955 to another mathematics student, the late Ruth (Martin) Polkinghorne. Later knighted, Sir Michael was President of the Royal Society in the early 1990s, the same period when Polkinghorne was president of Queen’s College, Cambridge.

​Sir Michael Atiyah (Source)

Polkinghorne was particularly inspired by the course in quantum physics taught by Paul Dirac, whom he has described as “undoubtedly the greatest British theoretical physicist of the twentieth century,” an opinion with which it is hard to disagree. For Polkinghorne, Dirac’s lectures were simply unforgettable: “so profound was the material, and so closely structured was the argument, that one was carried along enthralled by the experience.” (From Physicist to Priest, p. 26)

Paul Dirac (Source)

Remaining at Cambridge for graduate study, Polkinghorne worked under the Pakistani physicist, Abdus Salam, who later became the first Islamic scientist to win the Nobel Prize, which he shared with Americans Sheldon Glashow and Steven Weinberg for contributions to unifying the electromagnetic force and the weak nuclear force. Then he did postdoctoral work at Caltech with Murray Gell-Mann, another future Nobel laureate for his work on quark theory, and attended the famous lectures by yet another future Nobel laureate, the late Richard Feynman.

After Caltech, Polkinghorne taught briefly at Edinburgh before returning to Cambridge, where he was soon elected to a new professorship in mathematical physics. Quantum mechanics (QM) is his specialty; his writings on both QM and its interaction with theological ideas are numerous. His book, The Quantum World, has sold more than 100,000 copies, and when Oxford University Press wanted a book on this topic for their highly successful series, “A Very Short Introduction,” it was Polkinghorne who wrote it. His former students include Nobel laureate Brian Josephson, “the most precociously brilliant undergraduate that I ever taught,” and Martin Rees, who was until recently President of the Royal Society.

Although Polkinghorne has never won a Nobel Prize, in 1974 he was elected Fellow of the Royal Society, the highest honor in British science. Three years later, at the top of his scientific career at age 46, he astonished his colleagues by announcing a decision to pursue ordination as an Anglican priest; two years later, he resigned his chair at Cambridge to enter seminary. Partly, he felt played out. As a former physics student myself, I do not find his diagnosis hard to accept: “In mathematically based subjects you do not get better as you get older. Somehow one needs mental agility more than accumulated experience, and it becomes progressively harder for an old dog to learn new tricks. It is unlikely that most people do their best work before they are 25, but most do before they are 45.” Or, to put it more succinctly, “I simply felt that I had done my little bit for particle theory and the time had come to do something else.” (From Physicist to Priest, p. 71)

Nevertheless, he also felt a genuine call to the ministry, for “Christianity has always been central to my life” and ‘becoming a minister of word and sacrament would be a privileged vocation that held out the possibility of deep satisfaction.” (From Physicist to Priest, p. 73) After seminary, Polkinghorne served as a parish priest for many years and later as canon theologian of Liverpool Cathedral. He was knighted in 1997—although, as an ordained minister, he declines to use the title, “Sir John Polkinghorne”—and was awarded the Templeton Prize in 2002. It has been altogether a life well lived for the kingdom of God.

Looking Ahead

I’ll return in about two weeks with a summary of Polkinghorne’s basic attitudes toward science and religion, which (in his view) have a “cousinly” relationship. In the meantime, readers are invited to read Zeeya Merali’s essay, “The Priest-Physicist Who Would Marry Science to Religion,” from the March 2011 issue of Discover magazine, and “An interview with John Polkinghorne,” by philosopher Paul Fitzgerald.

References

John Polkinghorne, From Physicist to Priest: An Autobiography (2008).

About a year ago I posted the first article in this series, asking whether recent advances in genomics made any difference to the Judeo-Christian notion of humanity being made in the 'image of God'. That article focused on DNA sequencing data from our closest relatives. This article will focus on the issue of genetic determinism.

Theologians have spent many centuries mining the rich vein of the 'image of God' metaphor. Central to the idea is humanity with spiritual capabilities and responsibilities, equipped for moral decision-making and a relationally rich life in community. Historically, the idea has contributed to the conviction that each human individual has an absolute value, independent of their ethnicity, educational level, health status or income.

Do recent advances in genomics threaten or support such a view of humankind, or are they just neutral? Irrespective of one's belief in God, or not, this is of more than passing interest. Imagine the poor person wrestling for years with the great questions of life and finally deciding to become an atheist, only to then be informed that a cognitive bias derived from his particular set of genetic variants made that decision pretty much inevitable anyway. Such news might be equally unsettling for the person who had just struggled to faith following years of agnosticism. Our deepest human feelings are closely connected with the idea that we choose our own path through life.

The flourishing of genomics in the early part of the 21st century has certainly conveyed the message to many that one's destiny is written into one's genome. Whereas scientists are generally scrupulously careful not to give the impression that there is any such entity as a "gene for" some human trait, by the time the latest discovery appears in the media, such caution is often thrown to the winds. The past year has seen the trumpeting of a "gene for happiness," a "kindness gene" and a "believer gene." It is not even a question of education, but "genes are to decide" if you are a "caring person." Genetic testing websites assure us that "your genes are a road-map to better health," and we all know that road-maps are fixed. Small wonder that there is a creeping genetic fatalism around that subverts the idea of personal responsibility.

Fatalism in itself impacts on human behavior. Studies have shown that subjects exposed to the writings of authority figures doubting free-will are then more likely to cheat. Conversely, workers convinced of the reality of free-will are rated higher in the work-place than those whose beliefs tend more towards determinism.

The reality is that recent genetics research has continued to move steadily away from any notion of genetic fatalism, highlighting the sheer complexity of the genome, and providing some fascinating examples of the ways in which our choices impact upon our own genomes. There is no gene "for" any complex human trait because in fact genes encode proteins or other types of information-containing molecules, and thousands of genes collaborate together during human development in interaction with the environment to generate the unique human individual that each person represents. Those requiring an introduction for the non-specialist are referred to "The Language of Genetics."

Epigenetics adds further layers of variation and complexity. This refers to the chemical modifications of the DNA that cause genes to be switched on or off. It is such epigenetic modifications that generate the 220 specialized tissues of our bodies. Such acquired changes can even be inherited across several generations, certainly in plants and animals, and maybe in humans as well. In choosing to smoke, drink in excess, or take drugs, we also choose to modify our genomes.

So it turns out that even identical twins are not really genetically identical, developing different profiles of epigenetic modification as they go through life. This no doubt contributes to the otherwise surprising result that the age of death of identical twins, who share identical genomes, is comparable with that observed in non-identical twins, whose genomes are as different from each other as any two sibs. In one study of 184 pairs of twins in Spain, the difference in the age of death between the identical twin pairs was seven years on average, but such averages hide the fact that the age differences ranged from a couple of weeks to eighteen years. In the case of the non-identical twins, the difference in age at time of death was nine years, and the range was three to nineteen years. So there was really not that much in it.

What would happen if there was a genetic marker that identified nearly everyone in prison, marking them out as genetically distinct from half the world's population? What would that do to our ideas about genetic fatalism and convictions about moral responsibility? As it happens that marker already exists. Out of 131 countries worldwide, an average of 96 percent of the prisoners are male and, in this case, no complicated genetic studies are needed to know that the genetic marker that identifies this population is the Y chromosome. So universal is the correlation between the Y chromosome and criminality that we can safely say that no other genetic correlation will ever be found between a variant genome and criminality that surpasses this one. And yet we still hold nearly all males responsible for their criminal actions and put them in jail as soon as they're convicted. Furthermore, we note that most people who possess a Y chromosome go through life without committing a crime. So having a Y chromosome, with its unique set of genes, does not "determine" human criminality, although clearly we cannot go to the opposite extreme and say that it is completely irrelevant for patterns of human behavior.

The point in citing such examples is not to suggest that our genomes have nothing to do with our lives. They certainly do, not least in their significant contributions to our personality differences. The point rather is that the latest results in genetics provide no grounds for fatalism, instead highlighting the richness and diversity of the human population, and our own moral responsibilities, including the challenge to be good stewards of our genomes.

An argument for the existence of God this is not. But for those of us whose world-view is shaped by the conviction that we humanity are made in God's image, it is good to know that the latest genetics is consistent with such a perspective.

Behe and IC

Since we have previously explored Behe’s idea of irreducible complexity in an entire series, we will not revisit it here in great detail. It is important, however, to reemphasize how Behe defines irreducible complexity (IC). As we noted in the first part of that series, Behe frames his ideas on IC as a counter to Darwin’s ideas of gradualism.

For Behe, the argument for IC is a critique of gradual evolutionary processes, of the kind that Darwin saw as necessary for his theory to hold. When Behe introduces and defines IC in his book Darwin’s Black Box, he has a key quote from Darwin on gradualism explicitly in view:

Darwin knew that his theory of gradual evolution by natural selection carried a heavy burden: "If it could be demonstrated that any complex organ existed which could not possibly have been formed by numerous, successive, slight modifications, my theory would absolutely break down."

It is safe to say the most of the scientific skepticism about Darwinism in the past century has centered on this requirement… critics of Darwin have suspected that his criterion of failure had been met. But how can we be confident? What type of biological system could not be formed by “numerous, successive, slight modifications”?

Well, for starters, a system that is irreducibly complex. By irreducibly complex I mean a single system composed of several well-matched, interacting parts that contribute to the basic function, wherein the removal of any one of the parts causes the system to effectively cease functioning. An irreducibly complex system cannot be produced directly (that is, by continuously improving the initial function, which continues to work by the same mechanism) by slight, successive modifications of a precursor system, because any precursor to an irreducibly complex system that is missing a part is by definition nonfunctional. An irreducibly complex biological system, if there is such a thing, would be a powerful challenge to Darwinian evolution.

(Darwin’s Black Box, p. 39)

The definition of an IC system is thus straightforward: it is a matched group of components, where all the components are necessary for the function of the system. The necessity of each component can be demonstrated by attempting to remove it – if the system no longer works if even one component is removed, it is by definition IC.

Behe and exaptation

The standard response to Behe’s argument from IC is to discuss the evolutionary concept of exaptation: that new systems and functions are cobbled together from components that have functional roles in other systems already present in the cell. Behe discusses, and ultimately dismisses this idea in Darwin’s Black Box as follows:

In Chapter 2 I noted that one couldn’t take specialized parts of other complex systems (such as the spring from a grandfather clock) and use them directly as specialized parts of a second irreducible system (like a mousetrap) unless the parts were first extensively modified. Analogous parts playing roles in other systems cannot relieve the irreducible complexity of a new system; the focus simply shifts from “making” the components to “modifying” them. In either case, there is no new function unless an intelligent agent guides the setup.

So for Behe, two points are clear: parts selected for function in one system cannot be exapted for use in other systems since they would require too many modifications; and the emergence of a new function is the indication that an intelligent agent is guiding the process.

Behe has responded to my previous posts to claim that the tandem duplication event that brought about the Cit+ actualization event should not be considered a gain-of-FCT mutation under his criteria:

The gene duplication which brought an oxygen-tolerant promoter near to the citT gene did not make any new functional element. Rather, it simply duplicated existing features. The two FCTs comprising the oxygen tolerant citrate transporter locus -- the promoter and the gene -- were functional before the duplication and functional after. I had written in my review that one type of mutation that could be categorized as a gain-of-FCT was gene duplication with subsequent sequence modification, to allow the gene to specialize in some task. Venema thinks the mutation observed by Lenski is such an event. He has overlooked the fact that there was no subsequent sequence modification; a segment of DNA simply tandemly duplicated, bringing together two pre-existing FCTs.

As an aside, quibbling over whether this mutation constitutes a “genuine gain-of-FCT” mutation is not my purpose here, since the definition is Behe’s to define, and I am not aware of anyone else in the scientific literature who uses Behe’s definitions. That said, I consider it passing strange to claim that a series of events that produced a gene that has a new sequence and functional properties distinct from either of its component parts does not constitute the production of a new “functional coded element.” If nothing else, it is a functional coded element that has not previously existed, cobbled together from parts of other functional coded elements, displaying new, adaptive properties. If according to Behe’s definition that’s not “new” or a “gain” then I guess it’s not, but that seems to me to torture the words “new” and “gain” beyond recognition. But I digress.

The important point for our purposes, however, lies elsewhere. Note carefully how Behe describes the Cit+ actualization event. By dividing the new aerobic citrate transporter gene into two previously existing FCTs, Behe is describing an exaptation event. The one FCT (the aerobic promoter) starts off as a necessary component of a gene transcribed when oxygen is present. As such it is under selection for that function, which has nothing to do with expressing a citrate transporter. The second FCT (the citrate transporter amino acid coding sequence) is under selection to be a citrate transporter, which has nothing to do with the function of the gene the promoter comes from. The Cit+ actualization event, then, exapts these two FCTs by placing them together to create a new function (which Behe does not mention).

And here’s the kicker: the new system (expression of the citrate transporter when oxygen is present) requires both FCTs in order to work. It has become a system of “well matched, interacting parts that contribute to the basic function” (i.e. transporting citrate in the presence of oxygen) “wherein the removal of any one of the parts causes the system to effectively cease functioning.”

In other words, it is a new IC system – a small and relatively simple system, yes, but nonetheless IC. Now, I’m fairly sure that Behe would not define this system as IC, since the documentation of an IC system evolving would seriously undermine his thesis. I am interested, however, in how he will handle this development, on two fronts. First, he would need to explain specifically why two exapted FCTs that are required together for a basic function does not constitute an IC system (if indeed he wishes to preserve his definition). Secondly, given that he allows for exaptation in this case, he needs to explain how exaptation is not a threat to IC in general. In Darwin’s Black Box he disallows exaptation altogether, but that option is no longer on the table.

In the next post in this series, we’ll continue to explore the evidence for exaptation as a means to build new FCTs, and go on to examine the implications of this evidence for Douglas Axe’s proposed limit to evolutionary mechanisms.

For further reading:

Blount, Z.D., Barrick, J.E., Davidson, C.J. and Lenski, R.E. (2012). Genomic analysis of a key innovation in an experimental Escherichia coli population. Nature 489; 513- 518.

Michael J. Behe, Darwin’s Black Box: The Search for the Limits of Darwinism (New York: Free Press, 2006).

Michael J. Behe, The Edge of Evolution: The Search for the Limits of Darwinism (New York: Free Press, 2007).

Michael J. Behe (2010). Experimental evolution, loss-of-function mutations, and “The first rule of adaptive evolution”. The Quarterly Review of Biology 85(4); 419-445.

With the complete genome sequence in hand, we knew the sequence and location of our genes, but what we didn’t know was how all those genes are regulated: how do the trillions of cells in our bodies know when to turn on or off all those genes? How do the hundreds of distinct cell types develop and function together, when they are all running on the same DNA “operating system?”

That’s where the ENCODE (short for Encyclopedia of DNA Elements) project comes in. Launched in September 2003, shortly after the announced completion of the Human Genome Project, the goal of the ENCODE project is “to build a comprehensive parts list of functional elements in the human genome, including elements that act at the protein and RNA levels, and regulatory elements that control cells and circumstances in which a gene is active.” In other words, the project seeks to understand how the genome “works.”

Early this month, researchers from ENCODE released more than thirty papers presenting their findings. During a Science magazine online chat, the project’s data coordinator, Ewan Birney, explained the outcome:

The ENCODE project aimed to start our understanding of how the human genome works. We know that (nearly) all the information that determines a human is in the genome, as we all start off as single cell with this DNA. However, we had a patchy understanding of how it works, in particular away from protein coding genes.

To work out how the genome works, we used the fact there are many tiny machines (proteins and RNA - RNA is very like DNA) in each of our cells which know how to "read" parts of the genome. By monitoring where these little molecular machines are on the genome, or how parts of the DNA are copied into RNA (there are quite a few different types of RNA as well), we start to gain some insight into the genome.

We did many such experiments, across different cell types (eg, one cell type was very similar to a liver cell type; another was very similar to a white blood cell). This way not only can we see what is similar, we can also see differences between these cell types.

There is a lot more to get to know and understand here - this is definitely closer to the start than the end. But it is a substantial amount of data, and analysis, to start on this journey.

According to the abstract of one of the lead papers from Nature, this extraordinary glut of data “enabled us to assign biochemical functions for 80% of the genome, in particular outside of the well-studied protein-coding regions.” Only 2% of the genome codes for proteins, but 80% or more has some biochemical function. As a Science news article put it, these 30 papers “sound the death knell for the idea that our DNA is mostly littered with useless bases.”

The pro-Intelligent Design organization The Discovery Institute has heralded the discovery as the “demise of junk DNA.” Casey Luskin writes for their blog Evolution News:

Let's simply observe that it provides a stunning vindication of the prediction of intelligent design that the genome will turn out to have mass functionality for so-called "junk" DNA. ENCODE researchers use words like "surprising" or "unprecedented." They talk about of how "human DNA is a lot more active than we expected." But under an intelligent design paradigm, none of this is surprising. In fact, it is exactly what ID predicted.

The extent to which the ENCODE project been able to identify function has been surprising—even exhilarating—though scientists have for some time been getting glimpses of the many ways in which segments of DNA can be “active.” Even in 1970 biologists knew that some non-coding DNA had function, and by 2003 there was a large body of work demonstrating that many non-coding elements acted as promoters, enhancers, insulators, and so on. Indeed, in recent years many have come to appreciate the fact that “junk” was never really an appropriate metaphor in the first place. Still, because sequencing of multiple genomes has shed such extraordinary light on key evolutionary mechanisms, many geneticists have focused on function primarily in terms of which regions do or do not contribute to the evolutionary fitness of their host, rather than whether they were merely "doing something" biochemically. What the impressive ENCODE project has done is open a treasure trove of new information that can only accelerate the pace at which researchers are able to explore the incredible subtlety and complexity of DNA, and refine the very concept of “functionality.”

So with all this in mind, is ENCODE a stunning victory for ID, as Luskin believes? Bryan College biologist Todd Wood thinks not. He writes, “I don't think that function equates to design, nor do I think that design requires or predicts function. They're not the same thing… my understanding of function does not require me to hypothesize God (or an anonymous designer, if you must) as the proximal cause.”

We agree. Indeed we would go on to say that evolution and design are not mutually exclusive. So while finding function is not sufficient to prove design, recognizing that function has arisen by way of evolution does not indicate that God was not at work. We at BioLogos believe God providentially works out his purposes—his designs—through the elegant processes of evolution, not in opposition to them.

Amazing as the new data are, it only strengthens and enhances our evidence for evolution. While much of the genome is “doing something” biochemically, it is still likely that the majority of the sequence is evolutionarily neutral (Senior Fellow Dennis Venema discusses the evidence for this “neutrality” in a post on our site, including a striking comparison between 29 different mammal genomes and the human genome). In fact, another ENCODE researcher participating in the Science magazine chat, John A. Stamatoyannopoulos of the University of Washington School of Medicine, thinks the findings align beautifully with evolutionary theory:

ENCODE's data provide a unique and powerful window through which to view evolutionary change. We can see those changes directly by lining up the genome sequences of many different organisms -- these line-ups have revealed millions of regions where all the genomes agree, indicating sequences that have been specially preserved by evolution while others have decayed away (ie freely changed their letter codes). We now see that a large proportion of these 'conserved' regions are lighted up by ENCODE annotations, indicating that they are marking spots in the genome that contain important instructions for cell function.

We’ve discussed “junk” DNA previously, including a multi-part series by Dennis Venema, and we’ve received many emails over the past few days asking for our comments on the ENCODE findings. On Monday and Tuesday, Dr. Venema will begin to offer his own thoughts on ENCODE.

A special thanks goes to Darrel Falk, Mark Sprinkle, Kathryn Applegate, Dennis Venema, and Tom Burnett for their contributions to this post.

It’s true that physics sounds scary to many people, and it can indeed be a difficult topic to learn. Yet I’ve always loved physics (my degrees are in physics rather than astronomy), because of the way that mathematical equations can describe and predict so much of what we see in the world around us. One reason I got into astrophysics is because the universe contains so many bizarre situations that we can’t reproduce on earth, like ultracold, or extremely high density, or extremely high magnetic fields. It’s a fun challenge to figure out which physical process will be the most important when the situation is so dissimilar to everyday experience. But if the word “physics” makes you shrink in distaste or fear, don’t worry. For the rest of this article, we’ll focus on a more friendly topic: astronomy.

In the last decade or two, our knowledge of the universe has grown dramatically as many new telescopes and spacecraft have come online. In this essay, I’ve selected some of my favorite recent astronomy photographs to share with you. As a professional astronomer and a Christian, I feel God has called me to share these wonders with the Church. Many times, these new discoveries are presented without any mention of God, and sometimes in a context of overt atheism. I want to share these things with you in a Christian context, with God as their creator.

The Milky Way

Have you ever seen the Milky Way? If you live in a rural area, you may have seen it many times. If not, it may have been a dramatic surprise when you first saw it while camping or traveling. On a clear night out in the country, the sky is strewn with brilliant stars—many more stars than you can see under city lights.The faintest stars form a creamy, smoky band from horizon to horizon. Our galaxy contains billions of stars, and thousands of those stars are visible to the naked eye. The stars appear in a band across the sky because we are viewing our galaxy edge-on, like looking at the edge of a dinner plate.

When David looked up at the night sky over Israel thousands of years ago, he may have seen the Milky Way, or a comet, or simply the brilliance of the full moon. Whatever the sky looked like that night, it inspired him to sing:

The heavens declare the glory of God; the skies proclaim the work of his hands. Day after day they pour forth speech; night after night they reveal knowledge. They have no speech, they use no words; no sound is heard from them. Yet their voice goes out into all the earth, their words to the ends of the world. (Ps. 19:1-4a)

The heavens are displaying the glory of God for all people to hear, proclaiming their message to people of every language, tribe, and nation. Just about anyone who looks up at the night sky feels a sense of wonder. Yet as Christians, we feel more than a vague sense of awe; we know the Creator of the heavens personally, as our own loving Father.

The heavens declare more than God’s glory. The universe is God’s revelation of himself to us, and teaches us about his character. As the Belgic Confession says about “The Means by Which We Know God,”

We know him by two means: First, by the creation, preservation, and government of the universe, since that universe is before our eyes like a beautiful book in which all creatures, great and small, are as letters to make us ponder the invisible things of God: his eternal power and his divinity, as the apostle Paul says in Romans 1:20. Second, he makes himself known to us more openly by his holy and divine Word, as much as we need in this life, for his glory and for the salvation of his own. (Article 2)

The natural world teaches us about God’s glory, power, divinity, faithfulness, extravagance, immensity, love, and other attributes. God’s special revelation in scripture is our primary place to learn of God’s character (Ps. 19 goes on to talk about special revelation in vs. 7), but the natural world can bring the message to our senses in a powerful way beyond mere words on a page. The Holy Spirit can use the natural world to get the message past our hardened or weary hearts. Nature illustrates these attributes in ways that enlarge our imaginations to appreciate afresh the glory of God.

The Sun

The Solar Dynamics Observatory was launched into space in 2010, the latest of several spacecraft to photograph the sun in detail. In Figure 2, the upper photo shows the face of the sun with a sprinkling of sunspots. The sun is powered by nuclear fusion reactions deep in its core which heat the hydrogen and helium gas till it glows. A sunspot is a place on the sun’s surface where the gasses are a bit cooler than the surrounding area, so that it glows less brightly and appears dark.

The lower photo in Figure 2 was taken the same day, but in X-ray light. X-rays are invisible to our eyes, but you have experienced them at the dentist’s office. There, the X-rays are produced by a machine, travel through the mouth, and are detected by film to reveal an image of your teeth. In this image, X-rays are produced by the sun, travel to the Solar Dynamics Observatory, and are detected by a camera to show an image of the sun. In X-rays, the sunspots are the brightest part of the image, not the faintest. If you look at the sunspot on the left edge, you can see bands of particles rising out of the sunspot in a looping path above the sun’s surface and falling back down on it. As the particles follow lines of magnetic field, they emit X-rays. The loops you see are not small—they are about the size of planet Earth! Because of modern spacecraft, telescopes, and cameras, we can see so much more in the heavens than what is visible to the naked eye. Thus, we are seeing more of what the heavens have to declare about God. In Psalm 19, David goes on to describe the sun:

In the heavens God has pitched a tent for the sun. It is like a bridegroom coming out of his chamber, like a champion rejoicing to run his course. It rises at one end of the heavens and makes its circuit to the other; nothing is deprived of its warmth. (vs. 4b-6)

If David had lived today, maybe he would have written about other properties of the sun, like the power of God as seen in nuclear reactions and looping magnetic fields. As it is, he makes two important points. One is the universal warmth of the sun, by which God provides for all life on earth. The other is the faithful path of the sun, day after day, unchanging year after year. In the book of Jeremiah, God promises his people that he will not break his covenant with them, any more than he would break his covenant with day and night and the fixed laws of heaven and earth (33:19-26). The sun is a persistent reminder, woven into our lives, of God’s faithfulness to his promises.

The Denisovans, an extinct hominid group that interbred with modern humans, made the news again lately with the publication of a more detailed study of their genome. One of the many interesting findings was that the Denisovans share the same chromosome 2 fusion that modern humans have. In this post, I review what we know about the origins of human chromosome 2, and then discuss the new Denisovan findings and their implications.

The origins of human chromosome 2: a brief review

Though I have discussed the evidence for a fusion event leading to human chromosome 2 before, perhaps a brief review of the evidence is in order. The human genome is made up of 23 pairs of chromosomes (for a total of 46 chromosomes). This makes us something of an oddity among living great apes, all the rest of whom have 24 pairs of chromosomes (for a total of 48). Given that there are many independent lines of evidence that support the conclusion that we share a common ancestor with other great apes, this poses something of a conundrum: how is it that our species arrived at this specific chromosome number? If we were to represent this “problem” on a phylogeny, or tree of relatedness, it would look something like this (not to scale):

Our closest living relatives, chimpanzees and bonobos, both have 48 chromosomes, as do all other great apes such as gorillas and orangutans. This pattern has one of two explanations, one of which is much more likely than the other. Either the common ancestor to these species had 48 chromosomes, and there was an event that reduced that number to 46 specifically on the lineage leading to humans (option A), or the common ancestor species had 46 chromosomes, and there were independent, repeated events that increased chromosome number in all other great ape species (option B). We can compare these options by placing the required event(s) on the phylogeny (again, not to scale):

It should be obvious that the option that requires the fewest events is the more likely one – in this case option A with an event that reduces chromosome number in the lineage leading to humans. The other option, that of repeated, independent events to increase chromosome number, remains a formal, but unlikely, possibility. Events that reduce chromosome number are not frequent occurrences, so Option A is more likely than Option B.

We can also find further support for Option A, because it predicts a specific type of event, namely one that reduces chromosome number. Since loss of a large amount of chromosomal material is almost always detrimental, we need an event that reduces chromosome number without losing information. One way for this to happen is for two chromosomes to fuse together and become one. Initially, this event would produce an individual with 47 chromosomes, where two different chromosomes get stuck together. Contrary to what is often assumed, this individual would be fertile and able to interbreed with the others in his or her population (who continue to have 48 chromosomes). In a small population, over time, two relatives who both have one copy of the fusion chromosome may mate and produce some progeny with two copies of the fused chromosome, or the first individuals with 46 chromosomes. Since either a 48-pair set or a 46-pair set is preferable for ease of cell division, this population will either eventually get rid of the fusion variant (the most likely outcome), or by chance will switch over completely to the “new” form, with everyone bearing 46 chromosome pairs. While not overly likely, this type of event is not especially rare in mammals, and we have observed this sort of thing happening within recorded human history in other species. Some mammalian species even maintain distinct populations in the wild with differing chromosome numbers due to fusions, and these populations retain the ability to interbreed.

Further evidence for a fusion event in the lineage leading to modern humans comes from comparing synteny, or gene locations and orders on chromosomes within modern great apes – an issue we have discussed here before. In brief, what we see in human chromosome 2 is exactly what we would predict for a fusion event. When compared to other great apes, we see the genes on human chromosome 2 match up, in order, with two smaller ape chromosomes. We also see that sequences used at the tips of chromosomes are present at the proposed fusion site, and that human chromosome 2 has not one but two sites for the cell cytoskeleton to attach to for cell division – but that one of the sites is mutated and not functional, though it lines up precisely with the location of this site on the appropriate ape chromosome. Together, this evidence consistently supports both common ancestry for humans and great apes, and specifically that the difference we see in our chromosome numbers arose due to a single fusion event. I briefly discussed this evidence in my last post where I describe how I teach some of this material and the compelling impact it has on students exploring the evolution question for the first time.

Enter the Denisovans

With that as background, we are now prepared to appreciate a new finding that comes from genomics work done on the Denisovan hominids, an archaic species that is more closely related to Neanderthals than to us, but that nonetheless interbred with some anatomically modern humans as they migrated out of Africa and populated the globe. (For those not familiar with the Denisovans, or the evidence for our interbreeding with them, both Darrel Falk and I have written on this previously, here and here). Recently, a more detailed understanding of the Denisovan genome was published, and nested in the new information is the discovery that the Denisovans share the 46 chromosome set with the same fusion that we have. This strongly supports the hypothesis that the fusion event predates the separation of our species. If we were to represent this on a phylogeny, we can now place this event with more accuracy than before (as before, the phylogeny is not to scale):

Despite this new information, one obvious question remains. Did the Neanderthals also have the 46-pair set? From looking at the phylogeny above, we can see that the most likely answer is that they did, since the fact that the Denisovans had it strongly implies that the last common ancestor of humans and Neanderthals / Denisovans had it as well, and the Neanderthal-Denisovan split comes later. While the Denisovan DNA samples are of high enough quality to make this assessment, we do not yet have Neanderthal DNA of high enough quality to do the same analysis with current methods (though one additional feature of the new work on the Denisovan genome is developing more sensitive DNA sequencing techniques that may resolve this question in the future).

In other words, this fusion seems to be an ancient one, predating our species by several hundred thousand years. Present estimates of the last common ancestor between humans and Neanderthals / Denisovans range at about 800,000 years ago.

Implications for understanding our “becoming human”

The main implication from this work is that it places the fusion event well before the advent of our species. I’ve often chatted informally with Christians about evolution, and at times some have thought that this fusion event was what “started” our species, or made our species unable to interbreed with other groups. Some have even suggested that perhaps the fusion event was what produced the first human (i.e. Adam).

Note that thinking this way suggests a misunderstanding of how chromosome fusions occur and what effect they have on their hosts. A fusion does not precipitate a speciation event, but rather the individual with the fusion remains a part of his or her population, and able to interbreed, even if with reduced fertility. Also, there is no necessary biological effect or change that the fusion produces on the appearance of the organism. These misunderstandings aside, however,what this new evidence shows is that this fusion event took place long before modern humans arose at around 200,000 years ago. Indeed, the 800,000 years ago date for the last human - Denisovan common ancestor means that this is the most recent date possible for the fusion. While it is an interesting piece of our evolutionary history, it doesn’t seem to have much to do with how we came to acquire the traits that set us apart from, and ultimately outcompete, other similar species.

Recently, an elegant and powerful experiment was done to further investigate a question of interest to many evangelicals: how is it that we are so different from our closest biological relative (the chimpanzee) when our DNA is so very similar? Even when using estimates that maximize the differences, our genomes are 95% identical. The conclusion, that I have discussed here in the past is that a dispersed set of numerous small changes can have large effects on the form and function of an organism. Of course, small changes are what evolution specializes in: tinkering here and there, one mutation at a time, as we have directly observed in laboratory experiments. Before we discuss how this pivotal new study was done, however, a brief review of how genes work is in order.

Review: gene structure and function

If you’ve been following the ongoing Understanding Evolution series here at BioLogos, you will recall that we discussed gene structure and function not long ago, in the context of discussing non-functional DNA sequences (so-called “junk DNA”):

Genes have a typical structure (obviously simplified here somewhat). First off, there is the actual DNA sequence that specifies the protein product sequence (the so-called “coding sequence”, shown in blue). This sequence is usually broken up into segments in mammalian genes, and these sequences are spliced together when the DNA sequence of the gene is transcribed into a “working copy” called mRNA – a short duplicate of the code that can be used by the cell’s machinery to actually build the specified protein.

In addition to the actual coding sequences, other sequences are needed to tell the cell when and where certain genes should be transcribed into mRNA. Every cell in an organism has the same genes in their chromosomes, but not all are transcribed. Using different genes in different combinations is what makes cells take on distinct roles – for example, cells in your small intestine need different genes (for absorption of nutrients) than do cells of the immune system (for fighting off pathogens). Regulatory sequences make sure any given cell type has the right genes transcribed and made into protein products. Some of these sequences are part of the mRNA transcript (shown in red), and others are not transcribed but only part of the chromosomal DNA sequence (such as the “promoter” region that directs the enzymes responsible for making the mRNA transcript (shown in blue).

With this background in mind, we can now extend our understanding slightly further. DNA in cells is “packaged up” when not in use by winding it around a class of proteins called histones. This packaging keeps the DNA in a compact form, and it is useful in helping cells prevent genes they don’t need from being transcribed. For any given chromosome - which is one long strand of DNA – some regions will be packed away (and the genes there not transcribed), while other regions are unpacked (less tightly associated with histones) with the genes there actively undergoing transcription. The open regions allow for transcription because enzymes and other proteins needed for the process can gain access to the DNA there.

Comparing gene transcription across species at the genomic level

Because of the overwhelming similarity between the human and chimpanzee genomes (and the even greater similarity when examining only their protein-coding regions) it has long been hypothesized that changes in “where and when” genes are transcribed will be a major player in what makes our two species different (in contrast to the idea that we are different because of the relatively tiny changes in the coding regions of our genes). From an evolutionary point of view, there are a few ways to explore how differences in gene transcription arise once species go their separate ways, such as when our ancestors parted ways with our last common ancestor with chimps around 4-6 million years ago. The main idea is to compare the same cell type in both species: human skin cells versus chimp skin cells, for example. Determining what specific genes are transcribed (or not) in human cells and comparing the results to chimpanzee cells gives us an idea of how gene transcription differences arose in the two lineages since they last shared a common ancestor. The challenge, up until now, is that there was no easy way to indentify the changes in regulatory DNA that led to those differences in transcription. The problem arises because of the overwhelming similarities between our genomes: changes in transcription due to changes in DNA sequence are hard to find simply by looking for sequence differences, since in most cases the differences will be very small. There are also many small differences between our genomes that have no effect on gene transcription, so we cannot simply look for any difference at all. What we need is a way to identify which small changes led to differences in gene transcription.

Old hypotheses, new technology

Back in 2008, a method for addressing this issue was devised. As we have seen, DNA undergoing transcription is “unpacked” and accessible to enzymes. Researchers have long known about a certain enzyme, called DNAse I, that can cut exposed DNA but leave histone-packaged DNA alone. This means that DNA from any given cell type can be cut using this enzyme specifically at “DNAse I hypersensitive sites” (DHS’s) where regulatory DNA is unpackaged and a nearby gene is being transcribed. While this technique is decades old, what is new is a way to then go on to sequence the DNA next to each of these sites. This requires what is known as “next-generation” or “deep” DNA sequencing methods that can use a linker sequence to attach to the DNAse I cut sites and then amplify and sequence individual DNA fragments attached to the linker. Since we have the entire genome sequence of humans and chimps it is then trivial to take the sequencing results and map them to either genome. The results are a detailed map of what chromosome regions are unpacked and regulating transcription in each cell type. These maps can then be compared with related species across entire genomes.

It was only a matter of time before these powerful methods were applied to the human-chimp question, and the first results became available last month. The research group was of course interested in differences between the two species, and the results are fascinating. The researchers looked at several different cell types, and found similar results in all cases. The results for any given gene fall into one of several categories when compared to the human-chimp (H-C) last common ancestor:

• No differences in regulatory DNA relative to the H-C last common ancestor (1259 genes)
• Gain of regulatory DNA in humans relative to the H-C last common ancestor (836 genes)
• Loss of regulatory DNA in humans relative to the H-C last common ancestor (286 genes)
• Gain of regulatory DNA in chimpanzees relative to the H-C last common ancestor (676 genes)
• Loss of regulatory DNA in chimpanzees relative to the last common ancestor (211 genes)

While it was not surprising to find a significant percentage of unchanged genes, it was interesting to note the large percentage of differences in regulatory DNA, despite the overwhelming genomic similarity between the two species. Small changes had a large impact on gene regulation. The researchers went on to examine the new regulatory regions they had identified, and found that they showed evidence of being under natural selection. These mutations had not only brought change, but provided an advantage to their hosts.

These results underscore a few important points:

• Species become different because differences accumulate in both lineages once a common ancestral population splits into two. The differences we see in modern species are due to changes both species have accumulated over time.
• Tweaking the regulation of numerous genes appears to be a widespread mechanism for generating evolutionary novelty. Both gaining and losing regulatory sequences is common.
• These gains or losses in regulatory DNA require only very small changes at the DNA sequence level, but they can have profound impacts on how genes are transcribed.
• These changes appear to be widespread in genomes, and able to accrue in short evolutionary timescales.
• Small changes are exactly the sort of thing that evolution is known to be able to accomplish easily, one mutation at a time.
• These small changes bear the marks of natural selection, indicating that they were selected for as they arose.
• Anyone who wishes to call these differences “insignificant” will have to contend with the observation that the biological differences we observe between humans and chimpanzees are significant.
• Small, incremental changes at the genomic level fit nicely with the fossil evidence for human evolution, which, though fragmentary, indicates gradual changes in skeletal morphology over the same timescale.

Of course, this study is just the beginning, and future studies are sure to examine and compare additional cell types found in humans and our evolutionary cousins. These results have already added to the troubles of antievolutionary groups that wish to portray the differences between us as too great for evolutionary mechanisms to bridge. I suspect these troubles will only worsen in the coming years as these new techniques come into their own.

For further reading:

Shibata Y, Sheffield NC, Fedrigo O, Babbitt CC, Wortham M, et al. (2012). Extensive Evolutionary Changes in Regulatory Element Activity during Human Origins Are Associated with Altered Gene Expression and Positive Selection. PLoS Genetics 8(6): e1002789. doi:10.1371/journal.pgen.1002789

http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1002789

It has been widely reported that the moniker “God particle” was not its originator’s first choice. Still, Leon Lederman, director emeritus of Fermilab and Nobel laureate for neutrino research, did accept the nickname “God particle” because the particle is “so central to the state of physics today, so crucial to our final understanding of the structure of matter, yet so elusive.” “God particle” was quickly accepted by the press and general public because it seemed an appropriate title for a particle theorized to give mass to all elementary matter particles and the force carrying W and Z bosons. Serving this mass-giving function since near the beginning of the universe, a Higgs field (more fundamental than the actual Higgs boson ) must necessarily exist everywhere in the universe and be unchanging. With an omnipresent and immutable field, analogies between the Higgs boson and God naturally developed within the press and the public—“God particle” became deeply rooted. Relatedly, the Higgs boson become an excellent source for theological analogies. (See for example this article.)

Nevertheless, as physicists seek to emphasize, neither the Higgs boson particle nor its field have religious properties. Thus, elementary particle physicists are not fond of the “God particle” appellation. In the opinion of Oliver Buchmueller, of CERN’s CMS group, calling the Higgs boson the “God particle is completely inappropriate. It’s not doing justice to the Higgs and what we think its role in the universe is. It has nothing to do with God“. As Pippa Wells, another CERN scientist expressed, “Calling [it] the God particle … confuses people about what we are trying to do at CERN”. (Source: Reuters)

One alternate name for the Higgs particle that is used within the physics community is the “BEH” particle. “BEH” stands for Brout–Englert–Higgs, three of the six authors of 1964 papers that first proposed a mechanism for giving mass to elementary particles. In addition to Peter Higgs, the five other authors are Robert Brout and Francois Englert, and Tom Kibble, C.R. Hagen, and Gerald Guralnik. The process for giving mass to particles is thus sometimes referred to not just as the Higgs mechanism, but as the Brout–Englert–Higgs–Hagen–Guralnik–Kibble (BEHHGK) mechanism. (Saying all six names a couple of times makes it obvious why we most often only call it the Higgs.)

But issues of naming aside, what is the Higgs and why is it so elusive? According to the Standard Model, the particles that compose matter (the quarks and leptons) are in a category called spin-1/2 particles. The force carrying particles (the photon, the W's, the Z, and the gluons) are spin-1 particles. What the physicists above proposed was the existence of a type of spinless, or spin-0 particle. Not only does the Higgs boson form its own class of particles, it also gives mass to itself and to all the other particles that have mass: to all of the leptons and quarks, and to the W's and Z bosons, but not photons or gluons. This set of relationships is shown in the image below, indicated by the lines connecting the Higgs to these other particles. There are no lines directly connecting the Higgs boson to photons and gluons because the Higgs boson does not interact with these force carrying particles and, thus, photons and gluons remain massless.

But the story of the Higgs particle actually begins with the associated Higgs field, an invisible field (something like a generalization of an electric field) that has a non-zero, constant value everywhere throughout the universe. This Higgs field continuously interacts with all matter particles and the W and Z force carrying particles. Matter and massive force particles are slowed down as they move through the Higgs field, just as are balls rolling through thick mud. The Higgs field is sometimes described as a “cosmic molasses”. Different particles interact with the Higgs field to varying degrees—those interacting more, are slowed down more, those interacting less are slowed down less. Slowing down more equates to acquiring more mass. If not for the Higgs field, all particles would be massless, zipping through the universe at the speed of light. The universe would be without structure—no galaxies, no plants, no life. Without the Higgs field, not even atoms could have formed.

It was theoretically possible for elementary particles to have mass without needing to acquire it through interaction with a Higgs-like field. However, as the standard model of elementary particles developed in the 1950’s and 1960’s, elementary particle theorists realized that if particles had their own innate mass, rather than acquiring it, many beautiful symmetries of particle interaction equations would be broken. To keep the beauty and symmetry in the theory was the essential reason the BEHHGK mechanism was developed, which immediately led to the prediction of Higgs bosons.

When there is enough external energy in a given volume, the Higgs field also produces Higgs bosons. But the Higgs bosons are very unstable and quickly decay. This is the process that enabled the discovery of the Higgs boson at CERN. At CERN, protons are accelerated to high energies via electric fields and directed in circular paths via magnetic fields. The protons then collide and release large amounts of energy. When sufficient energy is released in a collision, the Higgs field can use this energy to produce Higgs bosons. The Higgs bosons quickly decay leaving evidence of their existence through particular combinations of leftover particles that they have decayed into. Among those predicted by the mathematics of the Standard model are the muons and electrons identified by the CERN experimenters. The image at the top shows the identities and paths of particles produced in one of the CERN proton-proton collisions whose results fit with what would be expected from the decay of a Higgs boson.

For a proton-proton collision at the CERN LHC, the above diagrams show both the dominant modes for creation of a Higgs with a mass around 125 GeV, and the two dominant decay channels (modes). The creation mechanism (shown schematically in the left half of each diagram above) involves virtual gluons, the carriers of the strong nuclear force (represented by squiggly purple lines) from the protons. The gluons fuse into a virtual top quark loop (medium blue triangle), which then emits a Higgs boson (squiggly yellow line). The top quark couples more strongly to the Higgs than any of the five other quarks, so the top quark contributes the dominant loop.

The Higgs boson then dominantly decays into either (i) 2 gamma ray photons (the squiggly green lines) via another intermediate virtual top quark loop or a virtual W gauge particle loop (dark blue triangle), or (ii) two Z0 gauge particles (squiggly dark blue lines), which each then decay into a lepton (specifically an electron or a muon)/anti-lepton pair (light blue lines).

The likely discovery of the Higgs boson, and its implied existence of the associated Higgs field, is an amazing success for CERN. Past research and experience at Fermilab and by elementary particle physicists throughout the world also contributed to the discovery. The Higgs boson was the remaining particle in the Standard Model of Particle Physics to be found. With it, the Standard Model is in some sense complete. (Nevertheless, many questions about the Standard Model still remain—many inspired once again by beauty and symmetry. In particular, several numeric values associated with particle masses and interactions could only be experimentally measured, as with the Higgs, and not predicted from the Standard Model.)

With the apparent success of these experiments and seeming confirmation that the physical universe is, indeed, reflected by the complex and beautiful mathematics of the Standard Model, the international physics community is eager to keep delving deeper into the structure of creation. In addition to trying to verify that the 125 GeV particle is, indeed, the Higgs spinless particle and not some more exotic, new particle, CERN physicists are simultaneously seeking to discover an entire new class of particles, resulting from a theorized symmetry called supersymmetry. Discovery of the associated particles, if they exist, will likely take a few more years. For these discoveries we can only wait in anticipation.

Updated July 12, 2012.

Judging from the flurry of headlines over the past week, one might be tempted to think that proof positive of God’s existence (or lack thereof) had just appeared out of a 27-km-tunnel buried beneath the Swiss-French border. This frenzy of news headlines and blog titles hailed the recent news that CERN’s Large Hadron Collider has discovered a brand new particle of a mass of 125-126 GeV, which is assumed to be the Higgs boson, or the so-called “God particle.” The discovery of the Higgs boson would certainly be a breakthrough for particle physics and cosmology, but would such a finding also radically redefine theology’s understanding of God or challenge the existence of such a deity? Is there actually any theological or religious significance in Higgs physics at all?

The short answer is “no,” which becomes apparent when one considers the widely-reported story of how it got named. In 1993, Nobel Laureate physicist Leon Lederman, along with science writer Dick Teresi, wrote a book detailing the history of particle physics starting with Pre-Socratic Greek philosophy Democritus and culminating with the hunt for the Higgs boson. Until this latest discovery, the Higgs boson was the elusive final missing piece of the puzzle known as the Standard Model—a collection of the fundamental particles that constitute our universe and the complex and mathematically-sophisticated relationships between them. Considering how incredibly difficult finding the Higgs boson was proving to be, Lederman wanted to name the book after that “goddamn particle,” according to some of his collaborators. His editor, however, would not allow it and so the name was shortened to “The God Particle: If the Universe Is the Answer, What is the Question?” And thus ‘the God particle’ was born, carrying with it more than enough social baggage for such a miniscule particle.

Particle physicist Dr. Zosia Krusberg (at right) is visiting assistant professor of physics and astronomy at Vassar College and thinks “the term ‘god particle’ is unfortunate. The Higgs boson is no more (or less) divine or spiritually significant than any other elementary particle within the standard model of particle physics.” It may be fundamental to explaining one of the most basic characteristics of the universe—namely the existence of matter and mass in addition to energy—but “it is no more (or less) important than any other physics principle underlying the Standard Model.”

Last week’s discovery was monumental in that it may have finally provided experimental evidence for the Higgs Mechanism and defined the specific energy of the resulting Higgs boson, but even this “breakthrough” for particle physics leaves many scientific questions unresolved. Finding the Higgs boson completes the Standard Model, but it does not do away with many other questions and shortcomings of the current state of particle physics, such as the constituent particles of dark matter, a quantum theory of gravity, and other “mathematically subtle problems.” Not to mention that there is still significant work to be done to determine the exact nature of this newly-found particle. According to Dr. Krusberg, this particle might behave just as the Standard Model predicts or it could instead be “a Higgs-like particle that will serve as a gateway into explorations of physics beyond the Standard Model." Krusberg continued, “And I guarantee that it is this latter scenario that most of us are hoping for: physicists love nothing more than discovering the shortcomings of their theories, since this is the first step toward more fundamental theories with even more predictive power!”

No, finding the Higgs boson does not answer all the questions of particle physics, much less lend insight into the existence (or not) of God. For that reason, Dr. Krusberg (like most physicists) bemoans the term ‘God particle’ and insists, “There really is nothing either literally or metaphorically god-like about the Higgs boson.” Indeed, one writer for the British journal The Guardian reached such a point of frustration about the name that he ran a competition for alternatives. The winner was “the champagne flute boson,” ostensibly because the bottom of a champagne bottle is an excellent and oft-used demonstration of the energy potential of the Higgs Mechanism. Or then again, perhaps it is simply because physicists thought that finally finding this shy particle would call for some of the bubbly.

On the other hand, some science writers and scientists can appreciate the ‘educational benefits’ of such a mysterious and controversial name because it attracts the attention of the general public and puts a relatable face on an extremely esoteric physics concept. Krusberg herself admits that “People are naturally drawn to the mysterious and the controversial, providing educators with great teaching opportunities.” But she worries about the larger social implications involved in “mixing the vernacular of physics and spirituality,” not least because such uncritical mixing can lead the non-scientific community to draw conclusions about the authority and reach of science that are not justified.

Understanding that the Higgs boson is not the literal stuff of God and that it does not prove or disprove God’s existence (as the name seems to suggest) extinguishes the fire under any sort of religious outcry. But this does not mean that its discovery is irrelevant to the discussion of science and faith, nor to the Christian community as a whole. As Dr. Krusberg remarks, “The recent discovery of [this] new boson at the LHC perfectly embodies the scientific process at its best (and thereby illustrates to the public why and how science works).” Scientific exploration of nature is not a fool-proof endeavor; healthy skepticism and accountability to a wide community of other researchers are absolutely critical to its success. But such evidence of the power and finesse of well-executed science as we saw last week is a testament to our ability to explore and understand the ‘how’ of the universe. God has equipped humanity with the desire, the intellectual abilities, and the collective will to recognize and explore the cosmic order and beauty of his creation. God has made our home knowable, and has given us the tools and capacities by which to know it.

At left, Cern researchers present their findings to a few hundred of their colleagues in Melbourne, Australia. Image © 2012 CERN

It is valuable, then, for the Christian community to understand and appreciate how science works, in part to recognize that there are many instances in which science and the church work in tandem in order to better understand and better serve the world. But I think there is something else we can draw from the story of the Higgs boson, too. The nickname ‘the God particle’ has touched nerves in religious communities because it implies that science has the ability to prove or disprove divine existence by physical means. Even though the physics community is by no means claiming insight into the divine, it is sometimes assumed by the religious community that scientists view their work as chipping away at God’s existence when they begin to understand something that was previously unknown, or known only “by faith” in esoteric theories and models.

And yet, regardless of motives or metaphysical interpretations, perhaps physicists' search for the Higgs boson is in fact an apt picture of our own search for God. How many times have we stared up at the starry ceiling in times of crisis and prayed fervently for some kind of sign from God to assure us of his presence? And how many times has that much-desired evidence appeared only in retrospect, when we look back to see God’s hand faithfully and elegantly working in ways inscrutable at the time? It took a community of physicists to discern the presence of the Higgs boson. But even so, they could only do so after the fact from the cascade of particle decays it sparked; they could not observe the particle itself directly. In a similar way, though we often do not see the working of God directly, “in the moment,” we still trust in his presence and providence, often depending on friends, family and the community of the church to help us see his hand in hindsight.

So while the discovery of the Higgs boson does not itself explain God, we rejoice at the subtle yet striking new insight we have into God’s creative genius via the Higgs boson and at the way God gives evidence of his faithfulness in the ordered creation itself. Perhaps, however, the greatest insight we can glean from this breakthrough is an analogy for the way God calls us to seek him and find him together, in the community of those who follow his son.

Tomorrow, Baylor University physicist Gerald Cleaver answers the question, "What is the Higgs boson?"

In the last post in this series, we introduced a paper by Chen and colleagues that sought to identify new genes in various Drosophila (fruit fly) species. The youngest (i.e. the most recently evolved) gene they found is one specific to Drosophila melanogaster, the species of fruit fly beloved by geneticists as a model organism. The gene is named “p24-2” (not the most imaginative name, but it serves its purpose) and the gene it is duplicated from is called “Éclair”. The Éclair gene is found in a number of Drosophila species. A simplified “family tree” of three Drosophila species (D. melanogaster, D. simulans and D. erecta) is shown below. The duplication event that generated the p24-2 gene happened within the lineage leading to D. melanogaster, but after D. melanogaster and D. simulans separated as distinct species:

Since the entire genomes of these species are now sequenced and available online, it is possible to look at the chromosome region where the Éclair gene is found in all three. By looking at this region in D. melanogaster, we see that the brand-new p24-2 gene is almost right next door to its “parent” gene, Éclair. Below is a screen shot taken when looking at this region using a Drosophila “genome browser” that is freely available online. The red arrow indicates the Éclair gene, and we can see p24-2 is just one gene over, and seems to be nested within another gene called “Unc-115b”. The green arrows are pointing to two different “versions” of how p24-2 is made into an mRNA working copy. The Unc-115b gene (blue arrow) has five different mRNA versions. (One of the p24-2 mRNA versions has a lot of Unc-115b sequence that is not used when the p24-2 protein is made).

(Click Image to Enlarge)

Finding a duplicated gene next door to the sequence it is copied from is pretty common in genomes – when chromosomes are copied or recombined during cell division, side-by-side copies of parts of chromosomes show up every now and then. It’s also not surprising to see a new gene cobbled together with another gene. In this case, Unc-115b and p24-2 are overlapping but separate functional entities: they each have their own protein sequences, but each includes the code of the other as a sequence that does not actually translate into protein. The details of how this “cobbling” happens aren’t important for this discussion, other than to note that the mechanisms are known and not rare. In the chart above, then, the orange sections indicate the active parts of the transcribed sequence, while the gray are sections that are included in the RNA molecule, but do not get used directly to code for the new protein.

When we look at this same chromosome region in D. simulans and D. erecta, however, p24-2 is missing. Éclair and Unc-115b are there, but p24-2 is not, since it arose after D. melanogaster separated from its common ancestors with the other species. (Note: this entire region is a mirror image in D. simulans and D. erecta when compared to D. melanogaster due to a large scale chromosome inversion that covers this whole area. So, while it looks “backwards” compared to the image above, that is not surprising, it’s expected):

(Click Image to Enlarge)

So, with the p24-2 gene in D. melanogaster, we have a bona-fide, recent gene duplication event. This gene is brand new, evolutionarily speaking (less than 3 million years old, given the calculated speciation times of D. melanogaster and D. simulans). Not only is it brand new, it is also essential for survival in D. melanogaster: if you remove it, the fly dies. Obviously, since every other Drosophila species lacks p24-2, this gene is not essential for survival for any other species. It’s new, and now it’s necessary.

Do new, essential genes refute the Intelligent Design (ID) argument from Irreducible Complexity (IC)?

So far, nothing we have discussed explicitly threatens the ID argument from IC, though it does threaten the ID argument that new information cannot arise through evolution, a topic we have discussed in detail before. Michael Behe, the main ID proponent of the argument from IC, has commented on this research by Chen and colleagues (thanks to commenter “Bilbo” for pointing this out). Behe’s rejoinder was to a blog post by biologist and atheist blogger Jerry Coyne, who used the paper by Chen and colleagues to attack Behe’s ideas. Since Behe’s reply deals with his understanding of how gene duplication relates to his argument from IC, I will quote it here at length:

I have never stated, nor do I think, that gene duplication and diversification cannot happen by Darwinian mechanisms, or that “they play almost no role at all” in the unfolding of life. (As a matter of fact, I discussed several examples of that in my 2007 book The Edge of Evolution. That would be silly — why would anyone with knowledge of basic biochemical mechanisms deny that, say, the two gamma-globin coding regions on human chromosome 11 resulted from the duplication of a single gamma-globin gene and then the alteration of a single codon? What I don’t think can happen is that duplication/ divergence by Darwinian mechanisms can build new, complex interactive molecular machines or pathways. Assuming (since he is in fact critiquing them) Professor Coyne has been attentive to my arguments, one background assumption that he may have left unexpressed is that he thinks the newer duplicated genes discovered by Professor Long’s excellent work represent such complex entities, or parts of them.

There is no reason to think so. A gene can duplicate and diversify without building a new machine or network, or even changing function much. The above example of the two gamma-globin genes shows that duplication does not necessarily result in change in function. The examples of delta- and epsilon-globin, which, like gamma-globin, presumably also resulted from the duplication of an ancestral beta-like globin gene, show that sequence can diversify further, but function remain very similar. Even myoglobin, which shares rather little sequence homology with the other globins, has not diverged much in biochemical function.

In his recent work Professor Long discovered that many of the new genes were essential for the viability of the organism — without the gene product, the fruitflies would die before maturity. Perhaps Professor Coyne thinks that that means the genes necessarily are parts of complex systems, or at least do something fundamentally new. Again, however, there is no reason to think so. The notion of “essential” genes is at best ambiguous. We know of examples of proteins that surely appear necessary, but whose genes are dispensable. The classic example is myoglobin. It is also easy to conceive of a simple route to an “essential” duplicate gene that does little new. Suppose, for example, that some gene was duplicated. Although the duplication caused the organism to express more of the protein than was optimum, subsequent mutations in the promoter or protein sequence of one or both of the copies decreased the total activity of the protein to pre-duplication levels. Now, however, if one of the copies is deleted, there is not enough residual protein activity for the organism to survive. The new copy is now “essential”, although it does nothing that the original did not do.

The main points of Behe’s reply can be summarized as follows:

1. Gene duplications and subsequent changes to the copies (diversification) can and do happen, but the results are nothing really “new”— no new molecular machines or pathways (nor parts of such pathways), nor much in the way of new functions.
2. Duplicated genes can become essential simply by “sharing” the original function, and then reducing their share to a minimum, perhaps through the amount of protein that each copy makes. Again, this is not anything really new, since the copy doesn’t do anything that the original didn’t do already. So, the finding that some gene copies are essential genes is not a threat to the IC argument.

Note that Behe’s reply makes predictions that can be tested with further research. These predictions might be summarized in this way:

1. If IC is correct, duplicated genes will not be part of new, complex molecular pathways or machines.
2. If IC is correct, duplicated genes that are both essential should “share” the original function.

Testing IC with new research

Behe’s reply to the Chen paper is of course hypothetical and speculative – as demonstrated by his own comment that “there is no reason to think” that the duplicated genes are components of new complex pathways or systems. Accordingly, the validity of Behe’s reply depends on its ability to hold up over time as more work is done. Of note, the functions of p24-2 and its parent gene Éclair have been studied intensively since 2010. These studies, as we shall see in the next post in this series, shed quite a bit of light on these questions.

For further reading:

Behe, M.J. Darwin’s Black Box: the Biochemical Challenge to Evolution. Free Press, New York, 1996.

Behe, M.J. The Edge of Evolution: the Search for the Limits of Darwinism. Free Press, New York, 2007.

Chen, S., Zhang, Y, and Long, M (2010). New genes in Drosophila quickly become essential. Science 330; 1682-1685.

The astronomy community is particularly interested in this event because exoplanets throughout the Milky Way galaxy regularly transit their parent stars in just the same way. This local example will allow astronomers to test and refine techniques used to determine the composition of these exoplanets' atmospheres, providing insight into whether these distant planets could possibly harbor life.

As Venus begins to cross in front of the disk of the Sun, Venus's atmosphere will refract the Sun's light, illuminating the backlit portion of the planet's atmosphere. Telescopes on the ground and in orbit will be trained on this thin arc of atmosphere lit up by the Sun. Astronomers will use spectrometers to break the light up into its constituent colors, from which they can determine the chemical composition of our over-heated sister planet's atmosphere. Once perfected, this same technique can be used to examine the atmospheres of planets far beyond our own solar system, offering us one of our best clues as to the habitability of these distant worlds.

Not only is this process of discovery exciting for natural science, but it has profound theological ramifications as well. Surely a God capable of orchestrating both the majestic swirls of a spiral galaxy and the intricate language of DNA could bring forth life where and when He chooses, but only now are we on the verge of being able to answer the age-old question: “Did God confine His creative life-giving actions to our own planet, or does His abundant fertility extent far beyond our limited experience?”

In 1882, William Harkness, the Director of the U.S. Naval Observatory, was one of two astronomers to determine from the transit of Venus the distance from Earth to the Sun. Just as previous viewers could never have imagined calibrating the scale of the solar system from such an event, Harkness could not predict its importance in 2004 and 2012 (the most recent Venus transits). As we look to the future, we can hardly imagine what new frontiers the next Venus transit of 2117 will find us exploring.

The image above shows Venus on the eastern limb of the Sun during the 2004 transit. As described in Tucker's essay, the faint ring around the planet comes from the scattering of light through its atmosphere, which allows some sunlight to show around the edge of the otherwise dark planetary disk. The faint glow on the disk is an effect of the TRACE telescope through which the image was captured. For more on the historical significance of the transits of Venus (including the voyage of Captain James Cook), see this article from NASA, which also includes links to several live webcasts of today's transit.

I ask the question, “Why is the universe so special?” Now scientists don’t like things to be special; we like things to be general, and our natural anticipation would have been that the universe is just a common or garden specimen of what a universe might be like.

But we’ve come to understand a lot about the history of the universe. We know that our universe started 13.7 billion years ago, and it started extremely simple, just an almost uniformly expanding ball of energy, about the simplest physical system you could possibly think about. But a world that started so simple has of course become rich and complex. With you and me, in fact, the most remarkable and complex consequences are its history, at least of which we are aware. The human brain is far and away the most complicated physical system we have ever encountered anywhere in our exploration of the universe.

That fact itself might suggest that something has been going on in cosmic history rather than just one thing after another. But we’ve also come to understand many of the processes by which this rich fruitfulness has come to birth. As we’ve come to understand these, we’ve come to see that though these processes are of course evolving processes, they took long periods of time – the universe was 10 billion years old before any form of life appeared in it, at least as far as we know anyway – and life of our complexity only appeared yesterday.

Nevertheless, the universe is pregnant with life, pregnant with the possibility of life, essentially from the beginning onwards. By which I mean the given laws of nature had to take a very specific, very finely tuned form, if the universe was to have so fruitful a history.

That’s a very remarkable discovery, and let me give you some examples of why we believe that. If you’re going to have a fruitful universe, one of the first things you have to get right is that you have to have the right stars in the universe. The stars are going to have a very important role to play. First of all, you must have some stars that are going to be very long lived, live for billions of years, steadily burning, steadily producing energy which will enable the development of life on one of the encircling planets. We understand what makes stars burn in that sort of way very well, and it depends on a delicate balance between the strength of gravity and the strength of electromagnetism. Electromagnetism is the force that holds matter together. The seats on which you are sitting are held together by electromagnetism and in fact you are held together by electromagnetism.

If you alter that balance a little bit in one direction the stars will begin to burn intensely, furiously, just pouring out energy and they will only live a few million years rather than a few billion years. If you move it a little bit in the other direction they will burn so slowly they will be brown stars and they will not produce enough energy to fuel the development of life. So you have to have a very delicate finely tuned balance between the strength of gravity and the strength of electromagnetic forces in a fruitful universe.

Remember, science takes the laws of nature, takes the given strengths of gravity, the given strength of electromagnetism, uses that to explain processes in the world, how things happen, but it doesn’t explain where those laws of nature come from. They are just brute facts as far as science is concerned.

And the stars have another absolutely indispensible role to play. The stars are the place where the heavier elements essential for life are made in the interior nuclear furnaces. There are many elements that are necessary for life, of which carbon is perhaps the most essential. Carbon is the basis of the long chain molecules, which are the biochemical basis of life. The early universe only makes the simplest elements; it makes hydrogen and helium and it makes no carbon at all. Carbon only begins to be made when the universe, which started uniform, begins to condense and become lumpy and grainy with stars and galaxies. As the stars condense they heat up, nuclear processes begin again in their interiors. And it’s those nuclear processes in the stars that make carbon and the heavier elements. Every atom of carbon in your body was once inside a star. We are people of stardust made in the ashes of dead stars.

And that’s a very beautiful process that takes place in that sort of way. And one of the great triumphs of astrophysics and the second half of the 20th century was to unravel that process. One of the people who did some of the most important work on that was a senior colleague of mine in Cambridge called Fred Hoyle. And they were trying to figure out how to make carbon. They got helium, and if you can make three helium nuclei stick together that will produce carbon, but when you have something as small as a nucleus it is impossible to get three to stick together at one time, they’re just too small.

Ok, so let’s do it step by step. Stick two together gives you berylium. Helium 4 gives you beryllium-8, hope it stays around for a bit, another helium comes along, attaches itself, and bingo, you’ve got carbon-12. That’s the obvious thing to think about but it doesn’t work in the obvious way, and the reason it doesn’t work in the obvious way is that beryllium-8 is terribly unstable. It doesn’t oblige you by staying around long enough to catch that third helium, at least in an ordinary, straightforward way.

But Fred realized that it would be just possible for this to happen if there was a very large enhancement effect, in the trade we call it resonance, occurring in carbon at just the right energy, it has to be the right energy, which would enable that attachment process to catch that third helium much much more quickly that you might have thought, in fact so quickly that some of them would get caught before the beryllium-8 disappeared. It was a very good idea, and he must have felt pretty pleased with himself and he went off to just check in the nuclear data tables of this particular resonance’s energy levels, and it wasn’t in the tables, but he knew it must be there, he’s carbon based life like you and me.

So he rang up some friends in the States, a father and son team who were good experimentalists and he said, “Look, you missed something. There’s a resonance and energy level in carbon that you haven’t spotted, and I’ll tell you exactly where to look for it. I know exactly where this energy has got to be. You go look for it.” And they said, “No, no, we don’t want to do that, we have more interesting things to do.” But Fred was very determined and he bullied them into looking for it and they found it.

Now that’s a wonderful achievement, to predict an energy level in carbon on the basis of how it might have been made in the stars is a fantastic scientific achievement. But it’s more than that. Fred had a lifetime conviction of atheism, realized of course that if the laws of physics had been just a little bit different that resonance wouldn’t have been there, and the possibility of carbon-based life is too significant for it just to be a happy accident in his view, so he says in a Yorkshire accent that is beyond my power to imitate, he said that the universe is a put-up job. Fred didn’t like the word God, and so he said some Intelligent, capital “I” Intelligence, must have monkied with the laws of nature to make carbon production possible. What that could possibly be I don’t know, but the more sensible thing to say is that creation is ordained, that the laws of nature would be such, as to enable the fruitfulness of carbon-based life.

We’ll come back to evaluating that possibility in a minute, but before we do, let me give you two other examples of how specific, how special, our universe has to be for us to be able to be here today to think about. We live in a universe that is immensely big, beyond our powers to imagine really. There are a hundred thousand million stars in our galaxy in the Milky Way, of which our sun is just a common or garden specimen, and there are about a hundred thousand million galaxies in the observable universe, of which our Milky Way is a pretty common or garden specimen. So we live in a world that is unimaginably vast, and sometimes we might feel upset by that and think, “What could be the significance of us who are simply inhabitants of a speck of cosmic dust, as you might say, in this vast, vast universe?”

Nevertheless, if all those stars were not there, we would not be here to be upset at the thought of them. Because there is a direct connection between how big a universe is and how long it lasts, and a universe that is significantly smaller than our universe would not have been able to last the 14 billion years, which is the necessary time to produce beings of our complexity. So that’s another condition of the world that has to be right for human beings, or something like human beings, to be a possibility.

One final example, which is the finest tuning of all: quantum theory suggests that there should be an energy attached to space itself. In quantum theory the vacuum, so called empty space, is not just a void. There are things called vacuum fluctuations which occur in a continual sort of seething mass of things coming into being and going out of being all the time. So while there is nothing there that doesn’t mean there is nothing happening. That may sound strange and paradoxical but believe me that’s what quantum theory implies. And of course these happenings, these fluctuations, generate a certain amount of energy, we call it “zero point energy”, and that energy is spread out over the whole of space. So we expect there to be energy associated with space.

And just recently the astronomers have discovered something called dark energy which is driving the expansion of the universe, which is just such an energy associated with space. Well that’s very good, you might say. However, when we estimate, just from thinking about quantum theory, how much energy there should be in space it turns out to be a fantastically large amount, and when we see the amount of energy there actually is per volume in space, it turns out to be very, very small in relation to that expected size. In fact, it turns out to be smaller by a factor of 10^-120. That means by a factor of 1 over 1 followed by 120 zeros. You don’t have to be a great mathematician to see that’s a fantastically small number. So some fantastic cancellation has taken place to turn that big number into the tiny number that we actually observe, and if it hadn’t taken place we wouldn’t be here to observe it because significantly higher energy would simply have blown the whole show apart too fast for anything interesting to happen. That’s the finest tuning that we know in the universe: one part in 10¹²⁰.

So we live in a world that is very remarkably finely tuned, and we have to consider that. And all scientists would agree about what I have been telling you; this is non-contentious. Where the contention comes in is what we might make of that, what is the further significance of it.

In the conclusion to Dr. Polkinghorne’s lecture, he looks at two explanations for the "fine-tuning" principle -- the multiverse theory and the existence of a divine intelligence -- and explains why natural theology alone is not sufficient to make the case for a God who interacts and cares for his creation. To make the case for theism, he argues, we need revelation, God's self-disclosure. This is manifest in various ways, including that which we experience personally, including ethics and aesthetics.

“The heavens,” wrote the psalmist “declare the glory of God.” (Ps 19:1 NIV)

The universe that inspired the psalmist three thousand years ago grows grander as each new generation of astronomers adds yet another layer of understanding. Each new discovery pushes back the boundary that separates the known universe from the vast terra incognita that beckons and teases us to keep going, to sail ever further from familiar shores.

A few centuries ago the great philosopher Immanuel Kant repeated the psalmist’s declaration: “Two things fill the mind with ever new and increasing admiration and awe, the more often and steady reflection is occupied with them: the starry heaven above me and the moral law within me. Neither of them need I seek and merely suspect as if shrouded in obscurity or rapture beyond my own horizon; I see them before me and connect them immediately with my existence."

The night sky still beckons us, as it once did the psalmist. I spend time each summer at a rustic family cottage in the wilderness of my native New Brunswick, Canada. There, miles from electricity, the night sky does not compete with artificial light. Smog does not obscure it. Planes do not draw white trails on it. It does not compete with cable television or even cell phones, silenced by the absence of signals. The night sky is simply there, quietly declaring the glory of God. Its many lights reflect off the ripples of the lake, and are accompanied by the rustling of leaves and the voices of the many creatures that call this wilderness home. Only a jaded soul could sit by that lake and not wonder if there wasn’t some larger meaning to the experience.

I can see what the psalmist saw and rejoice as he did. But I watch the night sky through the eyes of a twenty-first century scientist. I have the benefit of centuries of scientific advancement and can see, in my mind’s eye, so much more. Those visible stars are just the advance guard of an almost infinite army of stars going back almost forever. The stars are not attached to a dome that one might reach with an ambitiously tall tower or puncture with a long-range missile. They are so far away that their light has been traveling at unimaginable speed for years, centuries, milennia and longer. The light from the stars in the Hyades Cluster began its journey to the earth at about the time that my ancestors—Loyalists from Pennsylvania—began their journey to this part of North America in the eighteenth century. The light from the closest stars, the trio that make up Alpha Centauri, takes over four years to reach earth. The most distant star ever detected from the earth is a “gamma ray burster” that launched its signal almost 13 billion years ago, when the universe was young. The powerful gamma ray signal from this star began its journey before our planet was even formed, reaching the earth in April 2009.

The psalmist did not know that the stars were made of hydrogen and helium. He did not know they generated their energy through nuclear fusion or that many of them explode at the end of their lives. He knew nothing of galaxies and the layers of structure in the cosmos. He did not understand how fast light travels or that the light from our sun powers photosynthesis and many other processes here on the earth.

The universe brought into view by science is like a collection of Russian matryoshka dolls nestled one inside the other. With the psalmist we can see the outer layer—and it is grand. But inside are additional layers, each one with a new type of grandeur. And at the very end of the unpacking lie the remarkable laws of physics that keep the earth orbiting about the sun, the sun shining reliably, and the sunlight providing energy to sustain life on our planet.

The universe as we understand it today inspires awe. And for those open to its message—from the psalmists of yesteryear to the believers and even the thoughtful skeptics of today—it speaks of a Creator. Our universe does not look like a cosmic accident, where lots of stuff just happened. It looks like the expression of a grand plan—a cosmic architecture capable of both supporting life such as ours and of inspiring observers like us to seek out the Creator.

This is why Antony Flew—“world’s most notorious atheist”—changed his mind and started believing in God.

Dr. Owen Gingerich is professor emeritus of astronomy and history of science at Harvard University. He grew up in a Christian home and attended a Christian college in northern Indiana that had a motto of “Culture for service”, something that was very important in thinking about what he might do with his life.

When it came time to go to graduate school, one of his science professors told him “If you feel a calling to go to astronomy, you should give it a try, because we shouldn’t let atheists take over any particular field.”

And so he went on to a career in astronomy. In the late 1980’s, Dr. Gingerich had a unique opportunity to give a lecture at the University of Pennsylvania on the topic of science and Christian faith. Since then, he’s been trying to help people better understand God’s creation. For example, God could have made the universe in many different ways, but given the particular way it appears, it suggests that we wouldn’t be here if the universe were not very, very old, because out of the big bang came hydrogen and helium, but not oxygen and the iron we need for our blood, for instance. Those things came from the interiors of giant stars and had to cook for long, long periods of time before we got those elements abundant enough for sustainable life. It’s a marvelous picture, and Dr. Gingerich is actively involved in telling people about it.

By the time I was ten years old, I was already determined to follow a career in physics and cosmology, both because of the wonder I felt for the natural world and as a means to better resolve serious questions that were developing within me regarding the relationship between biblical interpretation and scientific discovery. The prior year I had read and studied scripture in its entirety for the first time, rather than just the piece-meal sections covered in my Sunday school classes. Whenever I look back at that year in my life, I am always glad I chose to study the New Testament before the Old Testament, rather than vice versa. From the New Testament study, I found salvation and accepted Christ into my life. But my examination of the Old Testament that followed raised serious questions for me, particularly regarding Genesis. Even as a ten-year-old, I could see the apparent conflict between Genesis and what I had already learned about the history of the universe, of earth, and of life on earth as reported by science. From science I felt amazement and wonder toward God as Creator and strongly desired to learn more about the physical laws set up by God that sustained the universe. In contrast, both of the Genesis stories of creation seemed simplistic and hollow.

As I continued to study, I came to believe that divine inspiration of scripture does not exempt scripture from portraying human authors’ limited (in particular, finite) understandings of the physical world.

Since Genesis 1 and 2 were written in a pre-scientific age, we should expect a non-scientific description of the creation process. Divine inspiration allowed the language of the time to express eternal truths regarding some aspects of God’s nature as Creator. Using stock images from the culture, the opening chapters of Genesis describe God as the ultimate Creator of all things and in charge of all things. These chapters should not be misinterpreted as scientific treatises describing the actual physics processes by which God creates all things.

From further study I came to understand that for almost two thousand years, many others far more knowledgeable than I had wrestled with the same issues. I was thrilled to learn that the early church fathers had developed a procedure for dealing with disagreement between scripture and scientific understanding. In 1657, the famous scientist, mathematician, and devoted Christian, Blaise Pascal, summarized the procedure of St. Augustine and Thomas Aquinas in his Provincial Letters:

When we meet with a passage even in the Scripture, the literal meaning of which, at first sight, appears contrary to what the senses or reason are certainly persuaded of, we must not attempt to reject their testimony in this case, and yield them up to the authority of that apparent sense of the Scripture, but we must interpret the Scripture, and seek out therein another sense agreeable to that sensible truth.... And as Scripture may be interpreted in different ways, whereas the testimony of the senses is uniform, we must in these matters adopt as the true interpretation of Scripture that view which corresponds with the faithful report of the senses.

An opposite mode of treatment, so far from procuring respect to the Scripture, would only expose it to the contempt of infidels; because, as St. Augustine says, “when they found that we believed, on the authority of Scripture, in things which they assuredly knew to be false, they would laugh at our credulity with regard to its more recondite truths, such as the resurrection of the dead and eternal life.” “And by this means,” adds St. Thomas, “we would render our religion contemptible in their eyes, and shut up its entrance into their minds.

During my teenage years, my conviction that science could be used to inform scripture and clarify our understanding and interpretation of it continued to solidify. I agreed with Galileo that, “the Bible tells us how to go to heaven, not how the heavens go.” Further, since God is the creator of all things, the physical and the spiritual, I came to understand that science as the study of the physical and theology as the study of the spiritual must be mutually consistent when both are properly understood. Inconsistency could only be the result of human misunderstanding of one or both arenas of knowledge.

(Some might correctly point out that science is not always as clear-cut as reason plus the report of the senses. That is, at times science also involves debates between competing interpretations, especially on the cutting edge of research. Nevertheless, ongoing scientific investigations gradually winnow away many or most proposed scientific descriptions of a given physical process, leaving only one or a few as the viable candidates. Scientific theories are formed by the general consensus of the scientific community based on overwhelming supporting physical evidence.)

In high school, I faced a serious medical problem, eventually identified as a brain tumor. Surgery was successful, in part due to a positive change in the tumor. In thankful response to God, I decided to pursue a career in church ministry. I determined a primary goal of my ministry would be to help the members of my future congregations develop mutually consistent and mutually supportive understandings of scripture and of science. I chose to attend Valparaiso University in Indiana, where I could, in addition to being a pre-seminary student, also double major in physics and mathematics to increase my scientific knowledge. Over the course of my four years at Valparaiso, I realized that my calling wasn’t for a church ministry, but one aspect of it would be to minister to Christians as a professional scientist, demonstrating by example that faith and science need not be at odds.

Thus, by way of a curved path, I did indeed follow the vocation I had initially chosen twelve years earlier. I decided once again to pursue the path that made my heart sing: studying the underlying laws and forces of the physical universe. As I was deciding which Ph.D. programs in elementary particle physics and cosmology to apply to, I became aware of a new, quickly developing subfield of particle physics called string theory that offered the possibility of unifying all of the known forces and matter in the universe into a single theory. I am now a successful scientist in this area, publishing discoveries that add to our understanding of particle physics and the universe.

In the next installment, Gerald Cleaver offers his advice to fellow Christians on how to seek after a consistent Christian worldview in which scientific and theological understandings of the universe are viewed as mutually supportive and complementary.